Download Our Application Questionnaire for Free Sample Testing BEE International homogenizing systems are suitable for a broad range of applications. Select your application from the list below for more information:

BEE International homogenizing systems are suitable for a broad range of applications. Select your application from the list below for more information:

•  Nano-Particle Size Reduction
•  Emulsions
•  Dispersions
•  Cell Rupture
•  Dual Feed for Abrasive and Viscous Materials
•  Dual Jet for Grinding
•  Processing Polymers

Most of today's applications for nano-particles such as sunscreens, targeted and controlled release drug delivery systems, transparent coatings, contrast agents, ink, etc. - utilize nano-particles in a liquid vehicle. To produce products such as these our customers need nano-particles in stable liquid emulsions and dispersions.

Emulsions are stable mixtures of oil and water, with one of them dispersed into the other in the form of fine droplets. There are "oil-in-water" emulsions, such as salad dressing and skin care creams, and "water-in-oil" emulsions, such as margarine and nutraceuticals. Surfactants are added to facilitate emulsion formation through the reduction of the interfacial tension, which reduces the pressure gradient required for drop breakup.

The following important factors affect the stability and efficacy of the emulsions:

• Droplet Size – surface area per unit volume and droplet size distribution.
• Narrow particle size distribution – most of the droplets at or below the target size and no "tails" on the distribution graph.

BEE homogenizers process emulsions to the smallest particles and the narrowest particle size distribution of all commercially available homogenizers. They achieve the particle size required by an application in a consistent and reproducible manner.

Many applications, such as injectible medications and fuel cells require suspensions of nanoparticles in an aqueous medium. Benefits of having small particles include:

  

Sterilization by filtration

  

Longer shelf life

  

Increased efficacy

  

Odor and flavor masking

  

Improved aesthetics

  

Finer liposome

  

Reduced toxicity

  

Ingredient protection

  

Controlled release

  

Non-surfactant creams

BEE homogenizers process emulsions to the smallest particles and the narrowest particle size distribution of all commercially available homogenizers. They achieve the particle size required by an application in a consistent and reproducible manner.

Cell rupture or disruption, is where the cell envelope is physically broken, releasing all intercellular components into the surrounding medium.

The controllable high intensity of BEE systems ideal for cell rupture, which is accomplished by three different mechanisms:

  

Impingement on entry to the nozzle area

  

High liquid shear in the nozzle

  

Sudden pressure drop upon discharge

  

The combination causes the cells to explode.

BEE homogenizers can achieve 100% cell rupture in a single pass!

Effortlessly process waxes, ceramics and metal powders!

Some materials are very hard to process by a nozzle based homogenizer:

  

Very viscous materials, which tend to clog the nozzle

  

Hot materials, which may affect non-metal seals

  

Hard and abrasive materials, which could cause rapid wear of the nozzle

  

Materials that must be fed in direct powder form

A key feature of BEE homogenizers is a unique Dual Feed feature, which makes use of high pressure for size reduction without passing abrasive materials through machine parts that are sensitive to wear. It enables metered amounts of the difficult material to be fed through a special port beyond the nozzle, there to be processed by the high speed jet coming through the nozzle, avoiding the above problems.

BEE homogenizers allow you to process waxes (with viscosity higher than 100,000cP), ceramics, metal powders, etc. with the same degree of ease as processing simple liquids.

  

Grind ceramics, metal powders and hard pigments.

  

Replace your bead mill or colloid mill systems with a reproducible, in-line process.

For solids with primary particle sizes that must be ground before further processing, BEE systems offer a Dual Jet feature. This creates two opposing high pressure, high speed jets of the product, and the intense energy dissipated by the impact and shear grinds the particles more effectively than any mill or mixer.

For very large particles and abrasive materials, the Dual Feed port can be used with the Dual Jet setup. BEE systems are in use worldwide for processing materials such as aluminum oxide, ceramics and pigments.

BEE homogenizers allow you to process virtually any material with the same degree of ease as processing simple liquids.

While there are many processes available to produce the final products from polymer pellets BEE Homogenizers are called for when in-line processing, greater stability, size reduction, nano or micro technologies are requirements.

Stable emulsion of a polymer

Unstable emulsion of a polymer