How Do Inline Mixers Work Differently Than High-pressure Homogenizers?

Posted by Tal Shechter on Dec 1, 2017 11:30:00 AM

inline mixersWhen they hear the term “homogenization,” many people think of milk. In fact, one of the first applications of homogenization came in the processing of milk. Derived from the Greek word “homogenos” (homos meaning same and genos meaning kind), it is defined as the process of reducing the particle size of an object and is also known as micronization.

Homogenization works by forcing a sample through a narrow space through multiple mechanical forces, thereby producing a stable and consistent product. Easily scalable, it is used by multiple industries, including pharmaceutical, biotech, cosmetic and food, in order to optimize their finished product.

Under the umbrella of homogenization lie two different methods: inline mixing and high-pressure homogenization. Read on to learn the differences between how the two work and advantages associated with each.

Inline Mixing  

Positioned within the production line and aligned with the flow of product, inline mixers consist of a stationary stator and an inside rotor that turns at high speeds. The rotor–stator device is contained in a casing with an inlet at one end and an outlet at the other, and the rotor is driven through a seal. Mixing occurs when a sample is drawn in through one of the mixing heads while the blades rotate and is then expelled at a high velocity through an opening in the stator. The inline term comes into play around the mode of sample entry into the mixing chamber.

Inline mixers feed and output material in a continuous stream, allowing material to often be perfectly hydrated, emulsified or homogenized in a single pass. They differ from other types of homogenization wherein large amounts of ingredients are mixed in a standalone unit before going through the homogenization process. Designed to handle all types of tasks, including emulsifying, suspending, dispersing, blending and more, inline mixers are suitable and useful for applications where larger quantities are needed for production and continuous processing and homogenization is needed during the manufacturing process. In addition to being faster than their high-pressure counterparts, they allow for a more controlled and continuous mixing environment, improve yields, use less energy and increase capacities.

High-pressure Homogenization

Whereas inline mixers rely on rotor/stator shearing action, high-pressure homogenizers force a sample through a narrow space using force and high pressure, thereby reducing particle size or lysing cells. They consist of a high-pressure pump and a disruption unit which enable a continuous homogenization. The higher the amount of energy applied during the homogenization process, the smaller the particle size or the more complete the cell lysis. The pressure along with the action of multiple forces yields impactful results in only one or two passes. Benefits of high-pressure homogenization include consistency in composition of products, greater stability of final products and decreased cost. Also high-pressure homogenizers allow users to set operating parameters - pressure, temperature, number of passes, valve and impingement design and flow rate – for a particular homogenization.

BEE International: Your Homogenization Equipment Headquarters

At BEE International, we offer a wide selection of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, biotech and more. Our products can help enhance your production, improve product quality and streamline your operations, all in combination with our unmatched customer service. Contact us today to learn more about our homogenization equipment and find out what product(s) is best suited to your business needs.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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4 Techniques in Cell Homogenization

Posted by David Shechter on Jul 6, 2017 11:30:00 AM

Cell HomogenizationCell homogenization, also known as cell micronization or cell fractionation, is the action of reducing the particle size of molecules to facilitate even distribution and emulsification of liquids, creams, or other mediums. This process is extremely common and is used in a number of growing industries: chemical, pharmaceutical, biotech, cosmetic, and food.

In the world of cell homogenization, there are several techniques that are commonly used to achieve this task. All of the methods involve encouraging the cells to lyse, or break apart. Cell homogenization can be achieved through various methods, including mechanical disruption, liquid homogenization, sonication, or manual grinding. Continue reading for a brief overview of each method of cell homogenization.

Mechanical Disruption

Mechanical disruption involves the use of rotating blades. These blades work to grind and disperse cells, and they are most effective at homogenizing tissues such as liver.  Rotor-stator homogenizers are one of the best homogenizing tools used in mechanical disruption and can homogenize samples in the volumes from 0.01 milliliters to up to 20 liters, depending on the type of motor that is used. Sample loss is typically minimal, and small amounts of samples and tissues can easily be homogenized using this method.

Liquid Homogenization

Liquid homogenization is the most widely used cell disruption technique, especially with small volumes and cultured cells. In this method, cells are lysed by the action of being forced through a small space, which acts to shear the cell membranes. There are several types of liquid homogenizers on the market, including Potter-Elvehjem homogenizers, french presses, and the dounce homogenizer.

Sonication

Sonication is a type of physical disruption used to lyse cells. This method uses high frequency sound waves to lyse cells, bacteria, and other types of tissue. The sound waves are delivered via a probe that is immersed in the liquid cell suspension. This method, while common, is often time consuming and is best suited for volumes of less than 100 mL.

Manual Grinding

Manual grinding, while one of the most time consuming methods of cell homogenization, is also the most common. In this method, a mortar and pestle is used to manually grind cells. While not suitable for extremely large volumes, this method is the most effective at breaking apart plant tissue cells.

BEE International offers a wide variety of high pressure homogenizers to meet the needs of virtually any industry. Our technology is well suited for nano emulsions, cell lysis, uniform particle reduction, and other related applications.

Contact us today to learn more about how our line of homogenizers can help with your company’s needs.

Also, be sure to check out our FREE eBook on 7 key factors to consider when choosing a cell lysis method

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Local vs. Systemic Steroids: What's the Difference?

Posted by Tal Shechter on Jun 13, 2017 2:30:00 PM

Local vs. Systemic SteroidsWhen most people think of steroids, images of elite athletes using synthetic hormones to gain a competitive advantage may come to mind. However, steroids – more often referred to as corticosteroids in medical circles – are often used to serve a very different purpose. There are numerous varieties of corticosteroid medications, including cortisone, methylprednisolone, and prednisone.

Steroids work by both reducing inflammation and decreasing immune system activity, and they are commonly used to treat a variety of diseases, including rheumatoid arthritis, eczema, asthma, and a host of other inflammatory ailments.

Steroids come in several different forms – local and systemic.  The form of steroid used is dependent on the ailment that is being treated, as well as the desired outcome.

Local steroid medications are best suited for ailments where a targeted approach is desired. These types of steroids can be introduced directly to the area in question and include eye drops, ear drops, skin creams, and joint injections.

Systemic steroids are best suited for ailments that require treatment throughout the entire body. Systemic steroids circulate throughout the bloodstream and reach every area of the body. They include oral medications as well as medications that are delivered intravenously or intramuscularly.

For both local and systemic applications, homogenization is an important process step to consider in industries that manufacture steroid-containing topical creams, ointments, and intravenous drugs.

In all applications, the even dispersion of active ingredients is critical to ensuring efficacy and decreasing manufacturing costs. Oral medications, for example, require homogenization and micronization of particles to ensure consistency throughout the product. Similarly, systemic steroids require the use of a homogenizer to ensure even dispersion and dissolution of the particles that make up the active ingredients.

BEE International offers a number of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, and biotech. Our homogenizers can meet the needs of virtually any environment – from small R&D settings and pilot plant operations all the way to 24/7 manufacturing environments.

For small sample sizes, as are often seen in laboratory and R&D settings, our Nano DeBEE is an excellent choice. This mechanical homogenizer uses multiple forces, including cavitation, turbulence, and pressure to create microscopic particles that can easily be dissolved in a variety of mediums, including liquids, creams, and organic solvents.

Contact us today to discuss the numerous benefits our homogenizers can offer to manufacturing your company's products. 

Also, be sure to check out our FREE eBook on how to achieve efficient and consistent particle size reduction

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3 Common Options for High Pressure Homogenizer Products

Posted by David Shechter on May 19, 2017 12:30:00 PM

homogenizer productsHomogenization, also known as particle size reduction, is a powerful technique that is used across a number of growing industries, including pharmaceutical, biotech, cosmetic, and engineering. This process involves forcing materials through a small orifice to disrupt, break, or otherwise reduce the size of particles within any given material. And while the process of homogenization may seem relatively simple, with it comes huge benefits: reduced costs, higher quality, increased customer satisfaction, and immense time savings. With benefits like those, its no wonder that more and more industries are looking to invest in a homogenizer of their own. However, before choosing a homogenizer for your needs, it is important to learn more about the benefits of this technique. And when it comes to products that benefit from homogenization, the answer may surprise you. Keep reading to learn more about 3 common options for high pressure homogenizer products.

Health, Beauty, and Cosmetic Creams

Lotions, anti-aging creams, and cosmetic creams can all benefit from the process of homogenization. Many creams are emulsion-based, and the right homogenizer can create these emulsions effortlessly, seamlessly, and consistently. Homogenization also allows industries to use water as both a solvent and diluent – something that is not easily achievable through other methods. With water acting as both a solvent and diluents, particles are able to dissolve rapidly and completely in just about every medium.

Pharmaceutical Drugs

In addition to creams, pharmaceutical products can also benefit from homogenization. The process of homogenization allows for the highest quality pharmaceutical drugs to be produced safely, reliably, and inexpensively. Particles that have had their sizes reduced are able to more readily and easily dissolve in solution, which allows for better and more effective drug delivery, more even dispersion of active ingredients, and higher safety and quality.

Beverages

Perhaps the most surprising benefit of homogenization involves the creation of beverages. Beverages can reap huge benefits from the processes of both homogenization and pasteurization. These processes often work hand in hand, and result in beverages that are full of nutrients, safe to consume, and are visually appealing, not to mention tasty! Another benefit of homogenization is increased shelf life among these types of products.

Homogenization offers a number of huge benefits, and this article barely scratches the surface. To learn more about the many benefits of homogenization, as well as the homogenization equipment available through BEE International, please contact us today.

For more information on cell lysis methods and how to choose the right one for the product you want, download our FREE eBook:

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3 Key Features of Intensifier Pumping Systems

Posted by David Shechter on Apr 12, 2017 12:30:00 PM

intensifier pumping systemsHomogenization, or particle size reduction, is, as the name suggests, the process of decreasing the size of particles. This popular technique is used in numerous industries for the manufacture of a wide variety of products, from pharmaceutical painkillers to anti-aging cream, and just about everything in between. But in order for homogenizers to do their job, the right technology is necessary. One such technology, one that is at the heart of our homogenizers, is Intensifier Pumping Systems.

We at BEE International have our own proprietary pumping system, designed for heavy duty, leak free, and long life cycle operation. This rugged system is designed for use in a wide variety of industries, including cosmetic, biotech, and even food. Our pumping system is made up of intensifiers that are actuated and synchronized by PLC – Programmable Logic Controller – to deliver constant pressure and flow through the homogenizing cell. Continue reading to learn more about our intensifier pumping system, as well as three key features that makes this technology the top of its class.

High Pressure Cylinder

The high pressure cylinder, also known as the HP cylinder, takes in product that flows from the system inlet port. During the suction stroke of the pump, it enters the HP cylinder, where it is then pushed out to the emulsifying cell (EC) during the power stroke of the pump.

Isolator

The isolator piece holds the hydraulic cylinder and the high pressure (HP) cylinder together, all while preventing cross contamination between the product fluid and hydraulic fluid.

Hydraulic Cylinder

Finally, the hydraulic cylinder, which is powered by the hydraulic power unit, takes in pressurized oil and pushes the hydraulic piston, which causes the piston to reciprocate.

These three sections of the intensifier pumping system work together to optimize the homogenization process, allowing for a process that is reliable, repeatable, and produces high-quality results. Other benefits of this technology include the following:

  • 5 different hydraulic cylinder sizes
  • 3 different high pressure cylinder sizes
  • Operating pressures of up to 45,000psi
  • Advanced intensifier controls allow for automation at the push of a button
  • Variable operating speeds to allow for the optimization of the process based on requirements
  • Ability to handle highly viscous materials
  • Long service life
  • Clean in Place (CIP) technology

To learn more about our proprietary intensifier pumping system, as well as more information on our wide variety of homogenizers, please contact us today. To learn more about the technology used here at BEE International, click here.

For more information homogenization and how to choose the right cell lysis method, download our FREE eBook:

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Methods of Liquid Homogenization

Posted by David Shechter on Apr 3, 2017 12:30:00 PM

liquid homogenization methodsHomogenization, or particle size reduction, takes place when particles, molecules, tissues, or other materials are reduced in size. This unique process offers a number of benefits, including more even particle distribution through products like creams, sauces, and medications; it also offers the additional benefit of improved texture, appearance, and taste, which leads to higher customer satisfaction and sales. With all of these benefits, it’s no wonder that more and more industries are looking to get involved with this process!

This article will explore the various liquid homogenization methods. Continue reading to learn more about the three most common types of liquid homogenizers: the French Press, the Potter-Elvehjem Homogenizer, and the Dounce Homogenizer.

French Press

The French Press is most often used for small sample volumes -- usually samples that are 250mL or less. In this method, a piston is used to apply high pressure to the sample, which forces it through a small hole, which homogenizes the product. While the French Press is efficient in homogenizing, since it is suitable for small samples only, the throughput is quite low.

Potter-Elvehjem Homogenizer

The Potter-Elvehjem Homogenizer is often used with delicate tissues, where the end desire is a ruptured cell wall (and not destroyed tissues!). This homogenizing equipment works in one of two ways: mechanically or manually. In both cases, a pestle is forced into a round shaped vessel to homogenize the cells. This homogenizer is not as efficient as a French Press, but is often more affordable.

Dounce Homogenizer

The Dounce Homogenizer is similar to the Potter-Elvehjem Homogenizer, in that a pestle is used to manually force cells through a small tube. The materials of a Dounce Homogenizer are often made of glass, which results in equipment that is easily sterilized and cleaned. However, like both the French Press and Potter-Elvejem Homogenizers, the Dounce Homogenizer is best suited for small samples, since the throughput is so low.

BEE High Pressure Homogenizers

BEE International offers a number of high quality, high-pressure homogenizers. Unlike the other homogenizers mentioned, our homogenizers are suited for large samples, and offer large throughputs, making our equipment ideal for laboratory, pilot plant, and even industrial use. Our equipment utilizes multiple forces – shear, turbulence, impact, and cavitation – to allow for results that are reliable, repeatable, and high quality.

We at BEE International would love to assist you on your next project. Please contact us today to learn more about our equipment and how we can help you enter the growing world of homogenization.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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3 Products that Benefit from Homogenization

Posted by Deb Shechter on Mar 31, 2017 12:30:00 PM

Number 3 in 3D isolated over a white background-248466-edited.jpegHomogenization, also known as micronization or particle size reduction, is the process of forcing materials through a small orifice to disrupt, lyse, or otherwise reduce the size of the particles within that material. And as those in the cosmetic, pharmaceutical, biotech, and food industries know, homogenization is a powerful process tool with countless benefits, including reduced costs, higher quality, increase customer satisfaction, and time savings. But what types of products can benefit from homogenization? The answer may surprise you. Continue reading to learn more about the products that reap huge benefits from the innovative process of homogenization.

Beverages

Beverages can reap huge benefits from the processes of both homogenization and pasteurization. These processes often work hand in hand, and result in beverages that are full of nutrients, safe to consume, and visually appealing. Homogenization and pasteurization work together to limit the growth of harmful pathogens, maintain flavor and nutrients, and can even improve the shelf life of the end product.

Pharmaceutical Drugs

The process of homogenization allows for the highest quality pharmaceutical drugs to be produced safely, reliably, and inexpensively. Particles that have had their sizes reduced through homogenization enjoy increased dissolution rates, which allows for improved drug delivery (especially via nasal or oral introduction), more even dispersion of critical active ingredients, higher safety and quality overall.

Cosmetic Creams

Cosmetic creams and lotions can also benefit from the process of homogenization. Most creams are emulsion-based, and homogenization allows these emulsions to be created more quickly, safely, and reliably than other methods.  Homogenization also frees up the possibility of using water as both a diluent and a solvent, since the smaller particles created within the emulsion dissolve rapidly and completely in virtually every medium.

BEE International: Homogenizers for Product Improvement

BEE International carries a wide selection of homogenization equipment that can aid production in your industry, regardless of the size of your manufacturing area. Our homogenizers are well suited for laboratory, research and development, pilot plant, and even full scale production environments. By utilizing the combined forces of shear, turbulence, cavitation, and impact, our homogenization equipment produces results that are reliably, repeatable, and high quality. Your customers won’t be the only ones amazed at the results!

Learn more about our homogenization equipment by contacting us today. We look forward to working with you on your next manufacturing project, big or small.

For more information on homgenization and cell lysis methods, download our FREE eBook:

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4 Benefits of High Pressure Homogenization

Posted by Deb Shechter on Mar 30, 2017 12:30:00 PM

benefits of high pressure homogenizationHomogenization is an incredibly useful technique that is becoming more heavily utilized in a number of manufacturing industries, including pharmaceutical, biotech, cosmetic, and food. Homogenization is an important step in creating high-quality products that consumers have grown to expect. With benefits including improved taste, texture, and consistency of products – when then translate to increased sales and customer satisfaction – it’s no wonder that more and more industries are clamoring to get a homogenizer of their own! Continue reading to learn about more benefits of high pressure homogenization.

Consistency in Composition of Products

High pressure homogenization allows for an even dispersion of ingredients within a medium; this is incredibly important for the pharmaceutical industry, where active ingredients need to be evenly dispersed within a pill, tablet, capsule, or syrup – and within the cosmetic industry, where customers expect their lotions and creams to have an even texture and appearance.

Increased Rate of Dissolution

Homogenization involves pushing materials through a shaft to create smaller particles; this is especially important in the world of dissolution, where smaller and finer particles facilitate easier dissolution. In the pharmaceutical industry, this impacts both the bioavailability and efficacy of drugs that are produced.

Greater Stability of Final Products

A successfully homogenized product contains particles that are so small and fine that they do not fall out of solution. This is incredibly important to the food and beverage industry – the last thing a customer wants is a bottle of juice that has particles visibly falling out of solution!

Decreased Cost

Another benefit of high pressure homogenization is its ability to not only enhance the safety of products – especially important both in the food and pharmaceutical industries – but to reduce overall costs as well. Effective high pressure homogenization often results in a reduced need for processing chemicals and thermal processing, and can also decrease the potential costs of product recalls.

BEE International: High Quality High Pressure Homogenizers

At BEE International, we take pride in our wide array of homogenizing equipment. We offer an extensive 1-year warranty on parts and labor, with unmatched customer service and training. Our homogenization equipment utilizes the forces of shear, impact, cavitation and turbulence to ensure the highest quality of emulsions, dispersions, and finished product. Our equipment is well-suited for laboratory, research and development, pilot plant, and industrial use. To learn more about our selection of homogenizers, please contact us today for more information.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Homogenization in the Chemical Industry: What to Look for in a Homogenizer

Posted by Deb Shechter on Mar 22, 2017 3:00:00 PM

homogenizationHomogenization, more simply known as particle size reduction, is a technique that is gaining popularity in a number of industries: cosmetic, pharmaceutical, and food are just a few of the industries that are utilizing technique. But did you know that the chemical industry also utilizes the process of homogenization? It’s true – homogenizers are being used more and more in this growing field. However, before you choose your next homogenizer for the chemical industry, it is important to know what to look for in a homogenizer. Continue reading to learn more about how homogenizers are used in the chemical field, as well as what features you should be looking for before choosing your next piece of homogenizing equipment.

Size Reduction Capabilities

When looking for your next homogenizer, it is important that it has the all-important capability to reduce size of even the most challenging of materials. A quality homogenizer will be able to handle both new and unusual particle morphologies while preserving existing morphologies, and will be able to handle one-step blending and formulation.

Dispersion and Emulsion Creation

In addition to being able to effectively reduce particle size, a high quality homogenizer will be able to create dispersions and emulsions with ease. A good homogenizer should be able to create dispersions and emulsions that allow for maximum particle packing, better particle coating during formulations, smoother surface quality, and increased conductivity.

BEE Homogenizers – What We Offer

If you are on the market for a high quality high pressure homogenizer for the chemical industry, you are in the right place. Our homogenizers offer the top size reduction capabilities on the market, the ability to create even dispersions and emulsions, and allow for accelerated chemical processes. Other benefits and features include:

  • Smoother surface quality of emulsions and dispersions
  • Menu guided maintenance and calibration
  • Data collection
  • Clean in Place technology
  • Synchronized pump system for constant pressure
  • Pharma/Bio/Food sanitary
  • cGMP and CE compliant
  • Password operated protection
  • Vertical and horizontal intensifiers
  • Maximum pressure of up to 45,000 psi

We also offer a 1 year manufacturer’s warranty, and availability to train new operators of our systems. Regardless of the setting or atmosphere, our homogenizers are sure to work for your application – whether it is in a smaller lab setting or a larger industrial zone. For more information on the homogenizers that we have to offer, please contact us today. We look forward to working with you on your next big project.

For more information on cell lysis and how to choose the right method, download our FREE eBook:

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How the DeBEE 3000 Can Benefit Manufacturing Industries

Posted by David Shechter on Mar 17, 2017 12:30:00 PM

laboratory homogenizersHomogenization, also known as particle size reduction, is a relatively simple process that is making huge strides in a number of industries: cosmetic, food, pharmaceutical, and biotech are just a few industries that have realized huge benefits from this technique. And with benefits like improved texture, taste, and quality of food, creams, and other consumer goods, its no wonder that more and more companies are looking to purchase a homogenizer for their business.

BEE International offers a number of homogenizers to suit virtually every environment and manufacturing industry. We offer homogenizers that work well in laboratory and research and development settings, as well as equipment that is well-suited for pilot plant and industrial applications. One such homogenizer is our DeBEE 3000. Continue reading to learn more about this powerful homogenizer and how it can help with your next homogenization project.

Cost Effective Production System

The DeBEE 3000 is our entry level model for pilot plants and industrial production applications. Its powerful features lend itself well to scaling up an existing process or creating a new process altogether. This powerful piece of equipment offers repeatable, high quality particle size reduction capabilities, with the maximum amount of efficiency, making it perfect for the creation of micro and nano emulsions and dispersions. In addition, the DeBEE 3000 allows for a high yield in cell rupture in less time than its competitors, making it an excellent choice for those looking to maximize their benefit to cost ratio.

Multiple Forces at Work

Similar to our other industrial grade homogenizers, the DeBEE 3000 harnesses the power of multiple forces to ensure the highest quality of particle size reduction on the market. This homogenizer uses the forces of shear, turbulence, cavitation, and pressure to create high quality emulsions and dispersions. These forces also allow this equipment to work with a number of particles and tissues, no matter how tough – or how delicate.

Other Benefits of the DeBEE 3000

Other benefits of the DeBEE 3000 include the following features:

  • Proprietary homogenizing technology for unmatched results
  • Hydraulically driven vertical intensifier pumps
  • PLC control with digital display for user friendly HMI environment
  • Quiet operation
  • cGMP and CE compliant

We at BEE International look forward to working with you on your next homogenization project. For more information on BEE International and the services we have to offer, please contact us today. For more information on cell lysis methods, please download our free eBook here.

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