When is the Right Time to Purchase an Industrial Homogenizer?

Posted by David Shechter on Jun 12, 2019 9:00:00 AM

Industrial HomogenizerIn manufacturing terms, bigger is often better, especially if you’re talking about the equipment that companies need to process the products they sell. Indeed, profitability frequently depends on a company’s ability to meet consumer demand while simultaneously maintaining quality and safeguarding costs. Many accomplish this by utilizing large capacity processing equipment to render bigger outputs in less time. By increasing product volume, decreasing manufacturing duration and maintaining the integrity and reliability of both via automated (not manual) processes, companies in all types of industries can generate bigger financial gains.

 

For those industries tasked with creating homogenized products, large scale equipment can facilitate better micronization, better mixing and better scalability (i.e., better overall results). If you’ve ever struggled to meet the demands of your customers or to verify the accuracy, efficacy, constancy and consistency of your products, then investing in an industrial homogenizer will likely solve a lot of your problems. Here’s how you’ll know it’s the right time to purchase an industrial homogenizer:

 

You Have High Product Demand

Industrial homogenizers are created specifically for bulk processing. Whereas laboratory homogenizers are perfectly capable of (and generally preferred for) handling small batch loads, industrial homogenizers can accommodate large quantities of materials, making it easier for companies to process a lot of product in less time. If you’ve moved past the initial research and development stage and have a final product to mass produce, it’s the right time to buy an industrial homogenizer.

 

You Need Flexibility for Processing

An industrial homogenizer is usually more versatile than a laboratory homogenizer, with advanced options available for tailoring processing functions according to individual need. At BEE International, our industrial homogenizers incorporate our patented Emulsifying Cell (EC) technology, a linear process that guarantees scalability of results each and every run. Our machines also include proprietary software, the “most advanced, reliable, and versatile intensifier technology on the market” and an automation system that allows for continuous operation, advanced data collection and integration with plant controls, generating countless opportunities for customization.

  

You Want To Minimize Costs

Bigger machines can cost more and warrant more maintenance. However, our DeBEE 4000 industrial homogenizer model comes equipped with hydraulically-driven vertical intensifier pumps that effectively lower maintenance costs and a “unique CIP position [that enables] flow through the high pressure cylinder for faster and more thorough cleaning.” Both of these features help keep our machines running smoothly and cleanly. Oftentimes, smaller homogenizing systems become overstressed trying to accommodate the processing of an unrealistic load. This not only wears out the machine’s mechanics, it requires more labor, more maintenance and probably more repair, all factors that accumulate more expense in the long run. A BEE International industrial homogenizer can mitigate that problem.

 

You Must Verify Safety Compliance

Manufacturing plants are required to adhere to certain sanitary and safety guidelines. Thus, most industrial homogenizers support compliance with FDA, CGMP and 3-A standards. Our BEE International industrial homogenizers offer this feature, as well as additional ones meant to make cleaning machine parts easier and more effective so that you can adhere to industry standards with minimal disruption to the production process. You should purchase an industrial homogenizer if you are required to verify any trade and/or government guidelines.

 

Want to Learn More?

Homogenizers are essential expenses for companies needing to homogenize and/or reduce the size of the particles in their product(s). Industrial homogenizers, in particular, can help large companies meet manufacturing demand, validate quality and ensure product stability and performance. All our equipment comes with a two year warranty to further protect your investment, your time and the trust of the people you serve. Contact us to learn more.

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What is a Polytron Homogenizer?

Posted by Deb Shechter on May 29, 2019 10:27:50 AM

Polytron HomogenizerIn the world of homogenizers, it’s a lot like Shakespeare’s Juliet said: “A rose by any other name would smell as sweet.” Depending on where you are and who you are, you might call a homogenizer a sonicator, a lysor, a bead mill, a high shear mixer, a disperser or a tissue tearor. You might even call a standard blender or whisk a homogenizer. Sometimes, people refer to all homogenizers by the brand name Polytron® (much like many call all tissues “Kleenex®”), and sometimes they specify the kind of homogenizer according to the type of force it supplies, like a mechanical, high-pressure or ultrasonic homogenizer. In the end, however, all these names refer to the same basic piece of equipment that is used by laboratories and in industrial processes to disrupt and blend the components of a product.  

 

But just because there are multiple ways to say “homogenizer,” it doesn’t mean each homogenizing application isn’t specific in some way. Indeed, the preferred way of referencing a homogenizer usually points to how it will be used, making it especially important for you to understand the differences in homogenizing applications.

 

For instance, in industry talk, a Polytron® homogenizer indicates a specific brand of immersion dispersers, which uses a rotating blade to dissolve solid particles in a liquid substance. Thus, “polytron homogenizer” is often used to reference a homogenizer being used with plant and animal matter in a lab setting. Similarly, “cell lysors” and “tissue tearors” are terms most likely used in biotech applications where it’s important that users maintain the cellular integrity of the products they’re manufacturing and/or studying.

 

The term “high shear mixer,” on the other hand, is more often used when discussing homogenizing processes for the food /beverage and chemical industries, where the mixing part of the homogenizing process is seen as being more emphasized than the disruption part (whether it’s true or not). In much the same way, you might talk about “bead mills” to indicate homogenizers used in industrial settings since they can accommodate the grinding of solid samples without a liquid.

 

Want to Learn More?

Choosing the right term to indicate each type of homogenizer is often confusing: Do you need a disperser? Do you call it a polytron homogenizer? And what about bead mills and all the other options? Add in the multiple ways in which each homogenizer can be applied, and you can quite easily become overwhelmed with possibilities! If you need assistance determining the right equipment for your needs, contact our team at BEE International. We offer a range of laboratory, pilot and industrial homogenizers that can effectively provide:  

 

Our proprietary and patented Cell Emulsifying System guarantees a customizable combination of homogenizing forces for optimal results and reduced costs. In addition, we offer stellar service, warranty support and preventative maintenance programs, benefits that enable you to maximize your time and resources and enhance the lives of the people you serve.

 

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Homogenizer Mixer: 3 Benefits for Your Application

Posted by David Shechter on May 2, 2019 4:43:57 PM

homogenizer mixer benefitsMixers come in a variety of shapes and sizes, from the common wire sauce whisks found in most home kitchens to the large drum mixers used in many industrial plants. Choosing one type over the other really comes down to what and how much you’ll be mixing, as well as how often you’ll be doing it. For example, a whisk is an appropriate tool for mixing cake batter, but you’d never try to mix cement for your new patio with one. And if you own a commercial bakery, you’d probably want an electric heavy-duty floor mixer that’s capable of stirring enormous amounts of ingredients day after day instead of a tiny whisk you have to beat yourself.

Another type of mixer is the high pressure homogenizer. At BEE International, our homogenizers pull product through a proprietary system that produces a constant pressure up to 45,000 PSI and pumps out a “high-velocity jet strong enough to cut metal.” The jet then enters our patented “Emulsifying Cell (EC)” and combines with other forces to yield a final product that is thoroughly broken apart and blended. Unlike other types of mixers, a BEE International homogenizer is versatile across many different applications. Here’s why:

Smaller Particle Reduction

Different mixers use different forces to break apart particles. For example, stirrers and agitators use turbulence; sonic mixers use cavitation; high shear mixers use shear; bead mills use impact; and high pressure homogenizer mixers use pressure. High pressure homogenizer mixers effectively reduce product particle size on their own, outputting products with better sensorial and biophysical properties with longer shelf lives. However, BEE International homogenizer mixers combine high pressure with all of the aforementioned forces, facilitating a gentler cell disruption and even smaller particle reduction than any other one mixer type. Operators can adjust the duration, intensity and type of forces used in the mixing process, ensuring that the cell walls of different biological materials are lysed in ways that preserve their intercellular components and

create a "tighter distribution of smaller particles [...] in fewer passes." This not only improves manufacturing efficiency, it reduces manufacturing costs!

Stable Emulsions and Dispersions

In addition, high pressure homogenizer mixers are so adept at reducing particle size that they also more successfully combine materials that don’t normally mix. The unique variety of forces used in BEE International homogenizer mixers especially combine to generate clearer nanoemulsions in all liquid products (emulsions) and more uniform distribution of solids within “liquid solutions, suspensions and colloids” (dispersions). Other mixers that only use one type of force can’t get particles small enough to enable that benefit.

Improved Pasteurization Results

Similarly, while high pressure homogenizer mixers can be used to remove pathogens from various types of food, BEE International homogenizers have the added benefit of allowing hold times under pressure to be customized. This means manufacturers can achieve maximum pasteurization results for a variety of products with only one machine. It also means operators can target specific organisms by applying the least amount and length of pressure necessary to kill each one, thereby preserving other vital components of the final food product for better taste, nutritional value and appearance.

Want to Learn More?

High pressure homogenizer mixers offer manufacturers and researchers a variety of benefits. They produce stable products with longer shelf lives, improved bioavailability and better rates of dissolution. And they do it with less waste and less resources since high pressure homogenizer mixers require less chemical and thermal processing to achieve maximum results. If you want to save time and money while still making superior products, contact our team at BEE International. We are industry leaders in quality homogenizing systems and can help you pick the right equipment for your own distinct needs.

You might also wish to download our free eBook, “How to Achieve Efficient & Consistent Particle Size Reduction,” for more tips on maximizing your manufacturing processes (as well as your ROI) with high pressure homogenizers.

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3 Common Problems High Pressure Homogenizers Can Solve

Posted by Jen Hug on Apr 11, 2019 11:30:00 AM

Problems High Pressure Homogenizers Can SolveHigh pressure homogenizers use pressure to force cell suspensions through narrow channels which break cellular bonds (also called cell lysis) and create uniform particles that are easier to manipulate. It enables businesses across a wide variety of industries (such as the pharmaceutical, chemical, biotech and food ones) to make products that are more stable and, thus, more reliable. Take a look at three common problems that high pressure homogenizers can solve for businesses needing to effectively disrupt cells as part of their manufacturing and/or laboratory processes:

Consistency

All industries, whether they make ice cream or sell flip flops or test medical vaccines, must maintain consistent product output or risk losing the public’s confidence (i.e., money). This means that each of their products and processes must be reproducible in the same way every time. And for many cosmetic, food and chemical businesses (to name just a few), it can also mean that each of their products has a physical consistency (viscosity) that is pliable and appropriate for its intended use. By using high pressure homogenizers with customizable controls, manufacturers and scientists alike are guaranteed uniform particle sizing. This necessarily yields products with the same ingredients and the same textures/densities with each manufacturing run, a great solution for a “constant” problem. 

Quality

Consistency is also unavoidably tied to quality. In the pharmaceutical industry, especially, it can be the difference between life and death. Often manufacturers and/or scientists encounter quality issues stemming from subpar materials and/or subpar processing. To solve these types of problems, they can use high pressure homogenizers which consistently deliver the same size and number of particles in any solution. Furthermore, high pressure homogenizers also effectively reduce particle dimension and tighten particle distribution, thereby ensuring that final products have less waste and more reliable ingredients. It’s critical for people needing drugs that actually have the right amount of active ingredients in them. And even when our lives don’t depend on it, it’s nice that we can buy mayonnaise that doesn’t separate and lotion that’s easily applied!

Cost

Finally, one of the biggest challenges facing businesses is how to reduce expenses and increase ROI. High pressure homogenizers have several features that make them the solution of choice for this problem. For instance, high pressure homogenizers so successfully reduce the size of and disperse particles that companies needing to mix ingredients in order to make a product can do so with a lot fewer processing passes. Fewer passes save companies both time and money.

In addition, most high pressure homogenizers are also capable of processing high volumes with higher yields than other options. And our patented high pressure emulsifying system here at BEE International further ensures that products made with our machines are more stable with longer shelf lives, creating long-lasting items that consumers feel confident buying and using. Finally, our high pressure homogenizers are easy to use, clean and service, compounding their value since less time, money and effort are spent on their maintenance. 

Learn More Now

These are just a few of the problems that high pressure homogenizers can solve. If you would like to learn how a high pressure homogenizer can streamline your manufacturing process and help you deliver superior quality and value to your customers and clients, contact our team at BEE International. We can help you better understand the various benefits of high pressure homogenization in all its applications.

 You might also like to download our free eBook, “How to Achieve Efficient & Consistent Particle Size Reduction,” for additional information.

 

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Particle Size Reduction Equipment: Why Homogenizers Stand Out

Posted by David Shechter on Feb 9, 2019 10:00:00 AM

particle size reduction equipmentReducing large materials into smaller ones is a common and often necessary occurrence in the natural world. From the earth itself eroding to food being digested to rocks being broken into tools, the physical process of reducing something into smaller bits frequently permits advantages (or wonders!) that otherwise wouldn’t exist. Take, for instance, the splendor of the Grand Canyon or the awe-inspiring fact that our bodies can break apart food and air and water into life sustaining nutrients or the many ways humans have made valuable tools from rocks and wood and other resources. Indeed, the world’s very first tool — the hammerstone — was made by ancient hominids and served a purpose not unlike today’s own particle size reduction equipment: to turn something bigger into something smaller.

Modern particle size reduction equipment is categorized according to four basic types:

  • Crushers - which break apart large particles into smaller ones
  • Grinders - which further crumble crushed particles into powder
  • Ultrafine Grinders - which pulverize ground powder into pieces 1-50 micrometers in size
  • Cutters - which yield particles of a specific shape and size

Considering product hardness, consistency and volume (many machines are better suited for certain capacities), companies may use one or more of the equipment types. Many pharmaceutical companies, for instance, opt for ultrafine grinders that can reduce active pharmaceutical ingredients into superfine particles to increase bioavailability. Baby food and soup manufacturers, on the other hand, might need cutting capabilities to ensure that all food pieces in their products are similarly sized. Some manufacturers might use crushing techniques followed by grinding ones or run their products through one system multiple times. It really just depends on the overall purpose of the product being manufactured, the initial ingredient composition and how much money a company has to spend.

With all this in mind, savvy manufacturers started considering the use of high pressure homogenizers as a fifth alternative for businesses in need of particle size reduction equipment. Homogenizers effectively mix together two normally immiscible substances using high pressure. A happy result of the process: homogenizers also reduce particle size! For manufacturers looking to make an equipment investment that not only works, but works across numerous applications, a high pressure homogenizer has become a solid choice. Unlike traditional particle size reduction equipment that only makes use of one type of mechanical force, a high pressure homogenizer utilizes several different ones. And at BEE International, our proprietary system not only uses turbulence, cavitation, high shear and impact to break apart product, it also has modular components that can be customized for specific purposes. Turbulence and cavitation treatments can be altered, shear times can be reduced or lengthened and impact and intensity can be tweaked. So, just want does all this mean? 

The Benefits of Using High Pressure Homogenizers (HPHs) as Particle Size Reducers:

  1. HPHs produce tighter distribution of smaller particles.

  2. HPHs achieve better particle reduction in fewer passes.

  3. HPHs increase manufacturing efficiency.

  4. HPHs reduce manufacturing costs.

  5. HPHs help create products with longer shelf lives, increased bioavailability and improved sensorial and biophysical properties. 

Want to Learn More?

Homogenizers can be used for a lot more than milk production and laboratory tests. Manufacturers in nearly every industry can use them to accurately reduce product particle size with a flexibility unmatched by other equipment types. Contact our team at BEE International for additional information on the ways a high pressure homogenizer can streamline your manufacturing process, improve your product integrity and benefit your bottom line.

Please feel free to also download our free eBook, "How to Achieve Efficient & Consistent Particle Size Reduction,” for more tips.

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How to Improve Oil Emulsification with a Homogenizer

Posted by Deb Shechter on Jan 31, 2019 11:00:00 AM

oil emulsification with homogenizersEmulsification is the process by which two naturally immiscible liquids are forcefully mixed together. Salad vinaigrettes, mayonnaise, butter, cold creams, lip balms and medicated ointments are all examples of emulsions. Depending on the ratio of oil to water, emulsions are typically categorized as either oil suspended in water (o/w) or water suspended in oil (w/o). Using the right emulsifying agent and the right kind of force, you can compel either type of mixture, effectively manufacturing many textile, plastic and paper products and improving the stability, bioavailability and viability for a variety of food, cosmetic and pharmaceutical ones (among others). Take a look at how a high pressure homogenizer can improve the oil emulsification process in particular, giving you better products in less time:

But First…The Difference Between an Emulsifier and a Homogenizer

Both emulsifiers and homogenizers forcefully mix many substances. But while an emulsifier only makes use of one type of mechanical force, a homogenizer makes use of many. At BEE International, our proprietary homogenizing system combines turbulent premixing with product progression through highly pressurized spaces, utilizing shear, cavitation and impact to break apart particles and uniformly mix and blend them. The result is a product with multiple benefits.

The Benefits of Using a Homogenizer in the Oil Emulsification Process

The benefits of using a homogenizer to create emulsified products are two-fold:

  1. It Reduces Particle Size

The high pressure and additional forces used by high pressure homogenizing systems (like those with our patented BEE International Emulsifying Cell technology) drastically reduce product particle size. Sub-micro particles have more surface area per particle, which means each has more opportunity to interact with another. This not only makes it easier for mixing agents to do their job (after all, they have a larger area on which to apply their “glue”), it also creates a final product with identical (i.e., homogenous) properties, improving the texture, consistency and appearance of many consumables, (especially important for those in the food and cosmetic markets) and increasing the bioavailability of drugs for the pharmaceutical industry.

  1. It Efficiently and Effectively Mixes Resistant Substances

The vigorous and multiple forces utilized by homogenizers make it harder for product particles to resist initial mixing and harder for them to separate afterwards. It also allows for large volume processing since homogenizers have greater capacities than traditional emulsifiers. The ability to create more stable products with longer shelf lives in shorter amounts of time with fewer passes saves time and money, valuable benefits for companies wanting to make the most of their resources.

Ready To Learn More?

The value of a high pressure homogenizer extends far beyond mere mixing of substances, making it the equipment of choice for companies wanting to maximize their processes while still achieving a superior meld. If you need assistance determining if or how homogenizers can improve your manufacturing turnover, as well as provide you with superior oil emulsifications, contact our team at BEE International. Our HPP homogenizers aid all types of businesses, including those in the food, pharmaceutical, chemical, biofuel and cosmetic industries and more. 

Feel free to also download our free eBook, "How to Achieve Efficient & Consistent Particle Size Reduction," for additional information about the value of smaller particle size within a manufacturing context.

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What Are Homogenizing Agents & How Do They Improve the Homogenization Process?

Posted by Deb Shechter on Dec 17, 2018 12:10:59 PM

homogenizing agentsFor most people, “homogenization” and “homogenizing agents” aren’t words that just roll off the tongue. But for us here at BEE International, talking about them comes as easily as discussing our favorite TV show or the day’s weather. So, if you’ve ever wondered what “homogenized milk” meant or how your face cream was made or why some peanut butter doesn’t have to be stirred, we’d love to share with you the facts about high pressure homogenization and homogenizing agents. Consider the following:

An Overview of the Homogenization Process

Homogenization is the process of combining two substances by breaking them into uniform pieces and mixing them together evenly. Homogenization facilitates many laboratory and manufacturing processes, such as those in the pharmaceutical, biotech, chemical, cosmetic and food industries. Not only does homogenization change the physical characteristics of materials, making it easier for scientists and manufacturers to work with raw components, it also helps ensure product quality, maintain long-term storage of materials and isolate certain particles when necessary. All of these things are necessary for superior performance among a variety of products. Homogenization makes our milk taste good and keeps our peanut butter from separating into a lump of peanut paste and a pool of oil. It keeps our lotions thick, yet spreadable, and our medicines effective.

But what if certain materials resist homogenization attempts by mechanical equipment alone? What if they need something more to help break them apart and realign their parts equally? In these cases, homogenizing agents are used.

What are Homogenizing Agents?

Homogenizing agents are resin-based mixtures which are usually added at the beginning of a homogenization cycle. When heated to certain temperatures, they turn “sticky” and help to moisten and soften the surfaces of the substances being melded together. 

How Do They Improve the Homogenization Process?

Because of their tackiness, homogenizing agents make it easier for some substances to blend and distribute their particles evenly. They also encourage filler acceptance. And by helping to shorten the time it takes to blend materials regardless of their “molecular weight, viscosity or polarity,” homogenizing agents save energy and other valuable resources.

In scientific and research settings, efficient homogenization can do more than just save time, though. It can also save lives. The right homogenizer and the right homogenizing agents can reduce the number of passes it takes to get viable results, ensuring that all steps in the testing cycle are consistent and go as smoothly and quickly as possible.

In more industrial settings, the right homogenizers and homogenizing agents ensure that applications are customized according to overall purposes, whether that be securing product stability; guaranteeing sterility; improving color, texture, taste and nutritional value; or simply maintaining cost effectiveness. 

Need More Info?

If you need help selecting the right homogenizer for your homogenization process, contact us today. Our high pressure homogenizers are customized to suit your own unique needs with multiple mechanical forces that create thoroughly mixed products.

And for additional information, you might also like to download our FREE eBook: "How to Achieve Efficient & Consistent Particle Size Reduction." In it, we show how equipment that reduces particle size saves you money by extending shelf life and strengthening biophysical properties. 

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Why We Love High Pressure Homogenizers (And You Should, Too!)

Posted by David Shechter on Aug 30, 2018 11:30:00 AM

Love High Pressure HomogenizersIf you were asked about some of your favorite products, a high-pressure homogenizer may not make the list. However, as we’ve discussed in a previous blog, the homogenization process produces a lot of products you most likely use and consume in your daily life. That’s one of the reasons we here at BEE International love homogenizers…but there are more! Let’s take a look at some of the most popular uses of high-pressure homogenization and the benefits they offer consumers.

Particle Size Reduction

High-pressure homogenization utilizes mechanical force to break down particles or droplets in a liquid into smaller and more uniform sizes, resulting in a dispersion, which is where fine particles of one substance are scattered throughout another substance. Dispersions can be further classified into solutions, suspensions and colloids, a mixture somewhere between a solution and a suspension.

Some high-pressure homogenizers can reduce particle size to as small as a single-digit nanometer. Plus, they ensure the composition is equal throughout, and the overall molecular makeup of the sample isn’t compromised. Many high-pressure homogenizers are able to produce emulsions, dispersions and suspensions at particle sizes of 100 µm or higher, and a select few can achieve a size of down to 0.1 µm. Key benefits of particle size reduction include:

  • Increased dissolution rate.

  • Improved drug delivery.

  • Controlled rate of reaction.

  • Increased density.

  • Consistent texture and product appearance.

  • Enhanced sedimentation stability.

  • Improved mineral processing.


Important Applications

Food and Beverages

Though one of the most well-known uses of high-pressure homogenization in the food and beverage industry is for milk, it is also widely used in the manufacture of sauces, spreads, salad dressings, fruit juices and concentrates, fish and meat pâté, sweeteners, baby food, egg product, other dairy products and more. It helps companies utilize to efficiently, cost-effectively and safely produce their goods. Food homogenizers also aid in the delivery of a product with uniform texture, flavoring and taste through a scalable process that allows for a longer period of freshness than food comprised of larger particles.

Pharmaceuticals, Chemicals and Biofuels

High-pressure homogenizers are used for numerous products from the chemical and biotechnology industries and products such as pharmaceutical tablet coatings, vaccinations and creams. They can be used to create cost effective medicines, modify microorganisms, synthesize new chemicals and develop alternative biofuels.

Cosmetic Creams and Lotions

Due to its ability to provide potent particle size reduction, enriched texture and consistency and strengthened emulsion stability, high-pressure homogenization is a preferred method for improving the production of cosmetic creams, lotions and other cosmetic products. It is especially beneficial for beauty creams and moisturizing lotions because they have to have a combination of the right texture and consistency in order for the skin to be able to effectively absorb them.

RNA Extraction

 Utilizing homogenization for RNA extraction enables processing to be effectively and repetitively processed in only seconds, thereby eliminating heat production. Its force and high pressure produce consistent and uniform samples, and it can process both small and large samples. Plus, homogenizers are scalable and compatible with many sample types, including those with tough cell walls. Using a powerful chaotropic salt solution, RNA extraction purifies RNA from biological samples by quickly disrupting cells or tissue to release the nucleic acids from the cells. These released RNAs are valuable in providing details on which genes are expressed (used to make products), to what degree the genes are active, how they work to regulate each other via small, regulatory RNAs and which structural RNAs (i.e. rRNAs, mRNAs and tRNAs) are produced.

Oil Emulsification

 Due to the fact that water and oil are immiscible, powerful mixing is essential to conducting oil emulsification. Therefore, specialized machines such as high-pressure homogenizers are preferred because they not only impart high shear but also are able to reduce particle sizes much more efficiently than other blending and emulsification methods. They are used in a wide variety of research and scientific uses and by many industries that require the use of active ingredients because they reduce active ingredients to a small enough size to ensure a thorough dispersion throughout the medium produced. Additional benefits of high-pressure homogenization for oil emulsification include production of stable emulsions, improved product consistency, shelf-life, texture, color and flavor and the ability to overcome the resistance caused by two immiscible liquids.

BEE International: Our Love for Our Products Shows in the Way We Treat Our Customers

BEE International offers homogenizers that are both high-quality and reliable. Our line of equipment is suitable for virtually every industry and can work in just about any environment. Contact us today to learn how our products can maximize your homogenization processes.

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The Ultimate Cheat Sheet for Choosing a Cell Homogenizer

Posted by David Shechter on Aug 16, 2018 11:30:00 AM

Businessman is standing in front of two direction signs.If you attended high school before laptops and tablet computers replaced books and used a landline to make phone calls, you’ve probably heard of CliffsNotes. Often used to help students figure out the intricacies of a novel that was required reading for English class, these handy pamphlets were a sort of a study guide highlighting the work’s key points.

In this blog, we’re offering you a CliffNotes version of tips for selecting a cell homogenizer that best meets your business needs. We’ll outline cell homogenization, often referred to as cell lysis, offer key factors for how best to achieve it and provide some benefits on it.

What is Cell Lysis?

Cell lysis, which takes place in biotech, pharmaceutical, food, cosmetic and chemical laboratories on a regular basis, is the rupture of the cell membrane resulting in the release of cell contents and the subsequent death of the cell. Research scientists and laboratory technicians disrupt the cell’s structure to extract organelles, proteins, DNA or mRNA. 

Cell lysis can be achieved through mechanical or chemical methods. Mechanical cell lysis techniques include high shear mixing, traditional homogenization, sonication, grinding, freeze/thaw cycles and high-pressure homogenization. Chemical cell lysis techniques include osmotic lysis and the use of detergents, chelating agents or chaotropic agents.

In order for cell lysis to be performed successfully, the following factors should be present:

  • Intracellular proteins should be accessible for extraction and solubilization.
  • The process should be flexible, as different cells require different cell lysis strategies.
  • The technique should result in a high yield in a short time.
  • The process should be relatively easy to perform.
  • Results should be consistently reproducible and scalable.

 

How Homogenization Helps

Of the methods used to achieve cell lysis, the most widely used is homogenization, which offers a multitude of benefits for production laboratories and the consumers who buy their products. It is especially useful for small volumes of cells and/or cultured ones and involves the use of shearing force on the cell. By forcing a small cell through an even smaller-sized orifice, homogenization removes the outer layer and lyses the cell. Some cell lysis products use utilize shear, and others employ sonic cavitation. However, the best choice when purchasing a homogenizer for cell lysis is one that uses shear, cavitation and impact and lets the user adjust the relative amount of each force for different applications.

The homogenizer you choose for cell lysis should be scalable to allow for customization in pressure and intensity, resulting in both cost and time efficiency for the user. It also must accommodate for multiple cell types and adjust for various sample sizes. Other factors to consider when selecting the right cell homogenizer are the force required to produce the highest yield in the least amount of time and the volume, efficiency, stability and sanitary standards compliance of the product. Advantages of using this type of homogenizer are:

  • Accessibility of intracellular proteins.
  • Built-in process flexibility.
  • Ease-of-use and low learning curve.
  • Reproducible and scalable results.
  • Various sample size processing.
  • Ability to disrupt all cell types.
  • Better results in fewer passes.

BEEI International: Bringing the Best Homogenizers to You

BEE International offers numerous high-quality homogenizers to meet the needs of any industry for cell lysis. Our laboratory-grade models include the Nano DeBEEMicro DeBEE and Mini DeBEE, all of which are easy to use, provide consistent and reliable results and easily scale up for full scale production. Plus, they offer maximum experimentation capabilities and the ability to change flow, pressure, shear and impact settings. Contact us today to learn more about our full line of homogenizers.

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Making the Right Choice: Homogenizer Manufacturers

Posted by David Shechter on Jul 31, 2018 11:30:00 AM

choosing high pressure homogenizerShopping for certain products is easy. If you want a fast food hamburger, you have a few well-known establishments from which to choose. If you’re looking to purchase some products to stain a deck or tend to weeds in your lawn, you most likely go to your local hardware store or one of a couple bigger, nationwide home improvement stores.

Investing in a more expensive product often requires more research and comparison. Usually, you can read customer reviews online or find ratings published by consumer organizations. When purchasing a homogenizer, however, it may be harder for you to obtain the advice needed to make the right decision.

First, let’s do a little refresher on homogenization. The primary methods used for homogenization include ultrasonic, mechanical and high-pressure, and homogenizers are used across multiple industries, such as:

  • Pharmaceutical: vaccines, antibiotics, cancer treatment and medicinal creams.
  • Food and Beverage: mayonnaise, ice cream, cream liqueurs, salad dressings, dairy products and more.
  • Biotech: creation of cost-effective medicines, modification of microorganisms, synthesization of chemicals and development of alternative biofuels.

Based on these details, the first step in finding a homogenizer manufacturer in asking yourself the following questions:

  1. Why do I need one?
  2. What differentiates one homogenizer from similar ones on the market?
  3. Does my product require a specific particle size?
  4. Which accessories are recommended and/or required for optimal performance?
  5. What motor power does my product require?
  6. Do I have a desired tube capacity and/or mixing speed?

By understanding the available options and what can best help you accomplish your specific homogenization goals, you are better equipped to select a manufacturer to meet your specific needs. It’s important to choose a manufacturer who will work with you to customize a homogenizer that delivers the best possible results. Some companies are able to customize the forces in their homogenizers to suit your application. Some even produce separate homogenizers for each phase of drug development.

Consistency is essential in homogenization, so employing the services of a manufacturer who aids you in reproducing reliable results is imperative. They should offer a homogenizer that is easy to scale and enables the product developer to quickly apply a wide variety of mixing techniques to a formulation. The manufacturer should have a reputation for reliability, offer customer referrals and provide you with at least once demonstration of their product(s).

Once you’ve decided on a manufacturer from which to purchase your homogenizer, factors to consider when choosing a brand and model include:

  • Sample types.
  • Maximum operating pressure. 
  • Mixing speed.
  • Processing setup. 
  • Processing range. 

 

BEE International: The Right Choice for the Best Reproducible Results

Our technology achieves superior results for nano emulsions, cell lysis, uniform particle reduction and related applications, and we offer homogenizers that are high-quality, customizable and reliable. Plus, we provide unparalleled customer service from demo to purchase and beyond. Contact us today for more information on our entire line of homogenization equipment.

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