David Shechter

Recent Posts

What Is Cavitation and How Does it Compare to Shear Mixing Forces?

Posted by David Shechter on Jan 27, 2022 9:45:00 AM

AdobeStock_459397952

Have you ever wondered: “What is cavitation?” If you’ve had a chemistry or biology class you may have encountered the term and learned a little about its meaning in various situations. 

Cavitation is basically the formation and collapse of “bubbles” (i.e., cavities) within a liquid substance that occur due to pressure changes. It can be a harmful process (like when vibrations work to erode mechanical parts), but in many instances, cavitation is a beneficial and often necessary part of certain types of industrial, medical and research processes. Thus, answering the question, “what is cavitation,” helps shed light on the role physics plays in our everyday lives. Here’s what you need to know:

The Simple Answer to “What is Cavitation?”

Cavitation is a type of force. 

As a type of force, cavitation changes energy, the very essence of life. It occurs when a liquid’s vapor pressure rises above its static pressure, causing pockets of vapor to form within the liquid. As the pressure again rises within the liquid, these “vapor bubbles” implode sending out shock waves that are able to break the bonds of surrounding particles. The resulting turbulence from these collisions and the destruction they cause then creates subsequent impact forces, which, in turn, cause even more bonds to disrupt. The result, a substance that has been broken up into tiny (often nano-sized) pieces.

There are Many Types of Forces That Can Be Used in a Variety of Ways

There are many types of forces. All forces occur naturally, but oftentimes humans use one or more types of force to create something or break it down. Doctors, scientists and manufacturers, for example, intentionally induce cavitation via the use of homogenizers in order to cleanse, study, test and produce a variety of substances. Sometimes they use cavitation machines to facilitate multiple types of medical treatments, as well. Together these products and processes include — but aren’t limited to — medications, paint, plastic materials, water purification devices and many different cosmetic, weight-loss and other medical procedures!

How Does Cavitation Compare to Shear Mixing Forces?

Cavitation is often a preferred source of energy force when making or using certain types of products because it’s extremely powerful and able to impact a large number of particles at one time, meaning more products can be made and more cells can be affected (when used with/for biological samples). Other types of forces, like shear mixing forces, can’t render the same effects. 

Shear mixing forces are forces that work in different directions to break apart and mix the particles of a substance. They’re a bit like a knife that chops away at an onion, dicing it at different angles. Because shear mixing forces move haphazardly, they aren’t as powerful as cavitation’s cyclic stress. Produced as the bubbles of cavitation rise, burst and shrink over and over again, cyclic stress is a controlled process, leaving a type of uniform destruction in its wake. Shear mixing forces, on the other hand, which utilize no established or reliable exertion of force, can’t be depended upon to break apart particles with any guaranteed conformity or regularity when employed singularly.

The BEE International Advantage

Cavitation is a useful and necessary process in many industries. It effectively disrupts cellular bonds and creates the smallest-sized particles, ensuring manufacturers and healthcare professionals alike have access to substances that can be better — i.e., more easily — mixed and, thus, making it possible for them to develop products that actually work

Here at BEE International, however, we don’t just recognize the power of cavitation, we aim to maximize it! We’ve designed a patented emulsifying (EC) technology that combines cavitation forces with shear and impact forces to ensure that industries have access to the smallest-sized particles possible so that even better products can be made. Our proprietary blend of multiple forces offers results that surpass the limited effects of shear, impact and even cavitation alone. Furthermore, our equipment is completely customizable, allowing users to intensify processes according to the task at hand. The result: the best high pressure homogenizers on the market today. Please contact us to learn more.

3 Industries Where Ultrasonic Emulsification is Changing the Game

Posted by David Shechter on Dec 28, 2021 10:45:00 AM

AdobeStock_145557608

Many industries depend on ultrasonic emulsification to get their products out the door and in front of customers. Put plainly, ultrasonic emulsification is basically vigorous mixing, and many industries use it because it is the only way to facilitate the combining of certain types of substances: those that are naturally immiscible, like oil and water, for example. Keep reading for a quick overview of ultrasonic emulsification, the industries that rely on it and info on an alternative piece of equipment that can vastly improve the process:

What is Ultrasonic Emulsification?

As mentioned, ultrasonic emulsification is a powerful way of mixing two liquids so that one is completely dispersed throughout the other and neither will revert back to its original properties over time. Of course, there are other ways of facilitating emulsification, but ultrasonic emulsification relies on ultrasound energy (high frequency vibrations that cause cavitation) to forcibly combine the two substances. Think about many popular food items, like salad dressing; you know that oftentimes you need to shake the bottle before pouring in order to evenly blend the dressing’s ingredients and not end up with a bowl full of oil (or vinegar) only! Ultrasonic emulsification is just a high-tech method of performing the same process. Since oil and water do not mix, (no matter how much shaking or cavitation is applied) an emulsifier or surfactant, an additional ingredient that mixes well with both water and oil, is added so that two substances mixed with the right mixing technology can stay mixed in a homogeneous state.

Industries that Depend on Ultrasonic Emulsification

In addition to the food industry, there are many other industries that create common and highly useful products via ultrasonic emulsification.

  • The Pharmaceutical Industry

In the pharmaceutical industry, it is often necessary to create oil-in-water emulsions in order to make medicines more palatable and to increase their efficacy by evenly dispersing their active ingredients. Without ultrasonic emulsification, for instance, many drug products would remain in an unmixed state, too bitter to ingest and/or unable to work effectively since they would inevitably deliver inconsistent dosages of the ingredients needed every time they were taken. It's just like that bottle of dressing that was not shaken before being poured and therefore spurted out alternating globs of oil and vinegar but never an actual vinaigrette.

  • The Beauty Industry

Similarly, most cosmetics, perfumes, and skin and hair care products need to undergo some type of emulsification process to ensure that they look appealing and can be applied evenly across the skin. Ultrasonic emulsification, in particular, simultaneously mixes and breaks apart substances into incredibly small particles (more so than mere mixers or blenders), enabling manufacturers to better guarantee that their products will possess a smoother consistency and be more easily absorbed into the skin. Furthermore, substances with smaller particle sizes are more stable, meaning they last longer than products that haven’t been properly mixed or have been mixed using only mechanical means.

  • The Cannabis Industry

Perhaps, however, the cannabis industry is currently reaping the best results as a result of their emulsification processes. In this rapidly growing market, the best-tasting and most potent cannabis products are the ones in demand. Ultrasonic emulsification allows manufacturers to guarantee a consistent product each and every time it leaves a production line since it reduces the size of cannabinoid molecules, making it easier for them to be absorbed by the body and also delivering a more uniform amount of active ingredient with every swig, bite, puff, swallow, chew, rub, spray or any other type of ingestion/application!

The BEE International Advantage

There’s no doubt that emulsification has changed the game for countless industries, allowing them to create products that last longer, taste better and/or provide better and more consistent effects than those that haven’t undergone the same type of robust processing. 

There is an even better alternative, though: high pressure homogenizers (HPH). Our HPHs here at BEE International, for example, utilize a patented Emulsifying Cell (EC) technology that surpasses the limited cavitation capacity of ultrasonic equipment and also employs other mixing forces of turbulence such as shear and impact. Control levels of each of these forces is in the hands of the user with BEE HPHs which means you can control the most efficient process for your product and the very best efficiency yield. Products emulsified with our homogenizers possess the tightest distribution of the smallest possible particle sizes and provide even higher quality products than ultrasonic mixers, sonicators, or other types of sonic mixers. Unlike sonication, BEE's proprietary homogenizing processes can scale up with ease as all our technology is built on the same platform (from R&D or Lab to pilot to manufacturing). Ultimately, this means companies spend less time and less money during their process manufacturing!

There’s a reason we’re called BEE; we offer the “Best Emulsifying Equipment” on the market. To learn more about our products and the technologies that make our HPHs the best option for your own emulsifying needs, please contact us today.

The Role of Nanoemulsification Equipment in Cannabis Beverage Processing

Posted by David Shechter on Nov 29, 2021 9:45:00 AM

AdobeStock_289940358_Preview

Nanoemulsification is the process by which a nanoemulsion is created. And a nanoemulsion is the combination of two immiscible liquids (such as water and oil) with particles less than 500 nm in diameter. Nanoemulsification equipment, then, is any tool that can be used to effectively create nanoemulsions. There aren’t very many of them, and some work better than others. For specialty jobs in a highly aggressive market, like cannabis-infused beverages, the nanoemulsification equipment that yields the absolute smallest-sized particles enables cannabinoid product manufacturers to gain valuable market share, offering cannabinoid drinks that deliver a faster, more potent effect than those of their competitors. Take a look at the reasons nanoemulsification equipment is needed — and why high pressure homogenizers are the best option — for cannabis beverage processing:

Nanoemulsification Equipment is the Only Way to Ensure Maximum Bioavailability and Efficiency in Cannabis Beverages

THC and CBD are two types of chemical compounds commonly found in cannabis products. Respectively, they are known for their euphoric or sedative effects, but only when absorbed by the body in some way. However, as fat-soluble molecules, neither THC nor CBD is easily nor quickly digestible if simply ingested in their natural state. Instead, the body has to move the cannabinoids through the digestion system, using bile and various enzymes along the way to break them into tiny particles that can then be more readily absorbed. In this way, the body itself basically has to create a nanoemulsion in order to allow the oil-based molecules in cannabinoids to be absorbed into the body.  It works…but it’s slow, delaying the body’s reaction to the various cannabinoid compounds, as well as never consistently guaranteeing the same type of effects. 

Using nanoemulsification during processing (i.e., before ingestion) solves the problem. By breaking down the cannabinoid oils with nanoemulsion equipment before they are imbibed, cannabis product manufacturers are able to mix teeny, tiny cannabinoid particles into a stable liquid phase (meaning they don’t settle to the bottom of the bottle). Fully and evenly dispersing the cannabinoids into a beverage ensures that the body immediately absorbs it, providing a more consistent product that always looks and works the same.

The BEE International Advantage

Our high pressure homogenizers here at BEE International are the only type of nanoemulsification equipment that can consistently create the tightest distribution of smallest-sized particles. Unlike other nanoemulsification equipment (such as sonicators and microfluidizers) that only utilize one type of mechanical force, BEE International high pressure homogenizers make use of a proprietary and patented Emulsifying Cell (EC) technology which combines multiple types of forces (shear, cavitation and impact) to more effectively break apart and mix the particles in a substance. Furthermore, our HPHs can be customized according to the job at hand. When making cannabis-infused beverages, for instance, manufacturers can adjust the combination of forces, as well as the intensity and duration of their application, so that cannabinoids are rendered to their smallest possible size in less passes. Please contact us to learn more.

You might also like to download our free eBook, “3 Reasons Why High Pressure Homogenization Improves Cannabis Products,” here.

The Ultimate Guide to Particle Size Reduction Equipment

Posted by David Shechter on Oct 28, 2021 10:15:00 AM

AdobeStock_89116698 (1)

There are hundreds — probably thousands or even millions— of reasons to break apart something that’s big into smaller pieces. From facilitating easier transport of active ingredients to encouraging in-depth exploration (and many other reasons in between), reducing a substance into smaller components often leads to more useful — if not just more plentiful — parts. Across multiple industries, for instance, particle size reduction processes enable manufacturers to create products that look and work better than those made without them. The key, however, is picking the right type of particle size reduction equipment; there are many ways to reduce the size of particles in a substance and, as a result, there are many types of particle size reduction equipment. It’s not always easy to know which type of particle size reduction equipment to use. Here’s what you need to know:

There are Many Ways to Reduce Particle Size

There are many ways to reduce the size of a substance’s particles; you can use molecular forces and/or mechanical forces. Unfortunately, molecular forces can alter the chemical composition of a sample, thus affecting the resulting end product’s functionality. Mechanical forces, however, only alter a sample’s physical structure and, therefore, are more often utilized in particle size reduction equipment. Indeed, at a most basic level, particle size reduction equipment depends on at least one of the following mechanical forces:

  • Shear — which is similar to cutting with a pair of scissors
  • Impact — which is similar to a collision between two objects
  • Cavitation — which is similar to the popping of a bubble


(In addition, high pressure can be used to force apart a substance, as well; we’ll get to that in a minute!)

The Type of Force Used Affects Particle Size Reduction

Specific types of particle size reduction equipment utilize different forces, with each offering their own unique advantages and disadvantages. For example:

  • Paddle Blenders utilize impact and shear forces to break apart large samples and are particularly conducive to separating living cells from tissue samples but not applicable when extremely small particles are needed.
  • Bead Mills utilize impact and shear forces by adding small beads to a sample and agitating them so that they collide with one another (and also the sample), breaking the sample into smaller pieces. Because small traces of the beads might end up in a sample, these type of particle size reduction equipment is not appropriate in certain situations. 
  • Rotor Stator Homogenizers utilize shear force to create small (although not nanoscale) particle sizes, but often create a small amount of heat that can degrade a sample.
  • Ultrasonic Homogenizers utilize cavitation and impact to create nano particle sizes, but can create a large amount of heat affecting many types of samples.

Only High Pressure Homogenizers Offer The Widest Range of Manufacturing and Scientific Possibilities

While other particle size reduction equipment makes use of only one or possibly two forces, our BEE International high pressure homogenizers utilize shear, impact, cavitation and high pressure to break apart and reduce the size of a sample’s particles. BEE stands for Best Emulsifying Equipment. Furthermore, our patented emulsifying cell (EC) technology permits the complete customization of forces (including their duration and intensity) used during any one manufacturing or laboratory process, which allows manufacturers and scientists alike the ability to achieve specific results as needed, such as nano emulsions; cell lysis; uniform particle reduction; maximum bioavailability; improved and consistent sensorial and biophysical properties and more!

 

To learn more about what makes BEE International high pressure homogenizers the particle size reduction equipment of choice, please contact BEE International.

How to Guarantee Water Soluble Cannabinoids for Beverages

Posted by David Shechter on Sep 29, 2021 1:05:00 PM

AdobeStock_287477642

Cannabinoids, chemical compounds found in the cannabis plant, are naturally fat soluble, meaning they are dissolvable only in nonpolar solvents and, thus, not capable of mixing with water. It’s a major problem that often makes the manufacture of cannabis-based beverages difficult since cannabinoids can’t be broken down and mixed with other ingredients naturally for any sustained amount of time. Cannabis-based beverage products, for instance, work faster, taste better and last longer only when they are able to be mixed properly with — read: dissolved completely within — other ingredients. Leaving cannabinoids in their original oily state, then, makes it impossible to guarantee the bioavailability, stability or longevity of cannabis beverages. Luckily, manufacturers have options. Here’s how you can create water soluble cannabinoids for beverages and, therefore, always ensure that your cannabis drinks are of the highest quality:

What are Water Soluble Cannabinoids for Beverages?

Technically, there are no “true” water soluble cannabinoids. What we actually mean when we use the term “water soluble cannabinoids for beverages” is really just “cannabinoids that have been reduced to the smallest-sized particles so that they can be thoroughly mixed with a liquid substance.” With this in mind, the trick becomes finding a way to break down cannabinoids into such small pieces that they can be used to manufacture cannabis beverages with maximized flavor and potency.

Using Emulsions to Create Water Soluble Cannabinoids for Beverages

As mentioned, if cannabinoids are left in their natural state, cannabis-infused drinks would need to be shaken and then immediately consumed. It’s not unlike an oil-based salad dressing that has to be shaken before used. This is never ideal, however, since shaking a product can actually degrade it: carbonated drinks lose their bubbles, for example, or ingredients get unevenly distributed, making the drink taste funny, look cloudy and/or rendering it unable to provide a consistent dose of active ingredient(s). Furthermore, because the cannabinoids are still basically fat molecules which have been only temporarily suspended in a liquid, the body must still process them through the digestive system, a much longer process compared to that of water soluble cannabinoids dissolving directly into mouth, stomach and intestinal tissues. 

To solve the problem, manufacturers need to create water soluble cannabinoids via emulsification. Emulsification is the process by which normally immiscible substances are mixed together so that separation can’t occur. There are several different types of equipment that can facilitate emulsification, but the most effective and efficient one is a BEE International high pressure homogenizer. BEE stands for Best Emulsifying Equipment.  Our high pressure homogenizers create stable emulsions that guarantee water soluble cannabinoids for beverages each and every processing run.

The BEE International Advantage

Most emulsifying processing equipment utilizes only one or two forces to physically break apart and mix samples. BEE International high pressure homogenizers, however, utilize a combination of forces, including turbulence, shear, cavitation, impact and high pressure, that more forcibly reduces a sample’s particle size, creating larger surface areas to which bonding can occur. The result: shelf stable mixtures with increased potency and bioavailability. In addition, our patented mixing technology eliminates the need for pre-mixing and includes customizable options for the combination of forces, as well as the intensity and duration of operation, allowing manufacturers to manage the production of water soluble cannabinoids for beverages in the fewest amount of passes, saving them time and money.

To learn more about using BEE International homogenizers to create water soluble cannabinoids for beverages, please contact our team today.

You might also wish to download our free eBook, “3 Reasons Why High Pressure Homogenization Improves Cannabis Products” for additional information.

How Cavitation is Used in Chemical Engineering

Posted by David Shechter on Aug 27, 2021 2:05:00 PM

AdobeStock_211363171

Cavitation is the rapid expansion and implosion of vapor-filled bubbles (or “cavities”) within a liquid substance. These cavities form when intense vibration within the liquid breaks its natural bonds and causes its ambient pressure to become lower than its vapor pressure. In many instances, cavitation is seen as a problem, causing functional changes in both natural and manmade processes that make reliable and consistent operational results impossible. In other cases, however, cavitation can be harnessed for specific manufacturing benefit, delivering products that are more effective — in both application and cost — than those made without it. Chemical engineers, for example, rely on cavitation to homogenize particles within colloidal suspensions, thus enabling them to create a wide range of chemical products including polymers, plastics, pigments, paints, pastes, pharmaceuticals and more! Read on to learn how cavitation is used in chemical engineering:

Cavitation is Used to Reduce Particle Size

In many (perhaps even most) chemical manufacturing processes, substances need to be mixed in order to be useful. Thus, first and foremost, cavitation is used in chemical engineering as a way to reduce particle size so that one substance can be more thoroughly combined with another one. Think about it: it’s a lot easier to combine small, uniform pieces than it is to combine large, various-sized ones!

Cavitation is Also Used to Improve Cohesion 

Furthermore, smaller particles mean more surface area; more surface area means more opportunities for particles to interact with one another; and more interaction ultimately yields better — i.e., tighter — cohesion. Because of this, the implosions caused during cavitation inception can be intentionally harnessed during chemically engineered product processing as a way to disrupt the natural bonds of a substance, creating products with a tight distribution of smaller particles that subsequently improve their consistency, viscosity, texture, appearance and even bioavailability (when applicable)!

Indeed, the uniformity of particle size and the cohesion it facilitates combine to provide enhanced product stability, ensuring more effective and a lot longer lasting products than those created in other ways.

The BEE International Advantage

In the chemical engineering world, cavitation isn’t just a problem to be avoided, eroding pumps and interfering with mechanical operations. On the contrary, cavitation can be used for advantage in many chemical manufacturing processes; intentionally initiating cavitation during production allows manufacturers the ability to create extremely effective, reliable and shelf-stable products. And if they use a BEE International high pressure homogenizer, the results can be further compounded. 

Want to Learn More?

Our proprietary emulsifying cell technology ensures the scalability and customizability of all types of chemical processing, benefits a lot of equipment used to induce cavitation on the market today can’t guarantee, as well as requires fewer passes of product to deliver maximum effect, saving companies time and money. Finally, the high pressure with which our homogenizers operate destroys potential pathogens, ensuring that all products made with our homogenizers are safe and free of biological contaminants. To learn more about the advantages of using BEE International high pressure homogenizers to induce cavitation during chemical processing, please contact us.

An Introduction to Creating Colloidal Solutions

Posted by David Shechter on Aug 13, 2021 1:50:00 PM

AdobeStock_224777398

Mixing is an important part of many processes, affecting the quality of numerous man-made (and nature-made) products. In laboratory and manufacturing settings, mixing often determines the overall value of a product, as well; mixed inappropriately, a product could end up being useless, costing scientists and manufacturers alike a lot of wasted time and/or money and offering no significant or effective operational merit. Thus, it’s important to know the different types of mixtures and their associated benefits. In this post, we’re going to discuss colloidal solutions, a type of mixture wherein tiny particles of one substance (liquid, solid or gas) are suspended within another substance (liquid, solid or gas). Here’s what you need to know about colloidal solutions, including how they’re created and what their differences from other types of mixtures mean for the people who use them:

What is a Colloidal Solution?

Multiple kinds of mixtures exist (solutions, suspensions and colloids/dispersions) with each one involving a specific process for its creation. For this blog, we’ll consider a colloid mixture (also commonly called a “colloidal solution” or “colloidal dispersion”), which is a mixture of one substance into another such that neither can be separated from the other. However, unlike a true “solution,” a colloidal solution does not involve the dissolution of one substance into another. Instead, a colloidal solution is comprised of particles that are evenly distributed (but not dissolved) within a substance in such a way that they can not settle nor separate from the medium over time. The key to this type of mixture is ensuring that the substance being dispersed into the associated medium is broken into particles that are small enough that they can be — and will always remain — thoroughly mixed with the medium containing them. Mixtures that don’t remain combined are known as suspensions.

How to Create a Colloidal Solution

The first step in creating a colloidal solution is breaking apart the product to be dispersed into the medium. There are several ways to facilitate this process; chemicals can be used to break apart a product and/or physical force(s), such as agitation, stirring, pounding, grinding, etc. High pressure can also be used, and our team at BEE International believes that our high pressure homogenizers provide the best options on the market when it comes to particle size reduction for colloidal solutions. Our homogenizers combine a variety of forces (high pressure, shear, cavitation and impact) to ensure nano-sized particles result in the least number of passes. These extremely small particles are then able to be fully distributed throughout the medium, thereby effectively creating a colloid solution.

Why Colloid Solutions are Important

Colloids are valuable because they prohibit the separation of two otherwise immiscible products. The milk we drink; the paint we use; the makeup we wear; the drugs we take: these are all example of colloid solutions. Because very small particles have been mixed in just the right way, many of the foods, paints, polymers, pastes, cosmetics and pills (and more) that we consume are able to exist. Mixed properly, they are consistently more stable, lasting longer than they would otherwise, as well as more attractive, remaining fully combined so that they look and feel smooth and cohesive. When applicable, colloids are also better tasting with better bioavailability. These are all important benefits of colloidal solutions.

Want to Learn More?

Creating colloidal solutions is a critical process that affords us with many useful and vital products for everyday life. To effectively disperse products within a medium, manufacturers and scientists need reliable, effective equipment. We believe BEE International high pressure homogenizers (HPHs) offer the tightest distribution of the smallest sized particles in the least number of passes, making them the best option for the creation of colloidal solutions. To learn more about our HPHs and the advantages they offer for a variety of processes, please contact our team.

You might also wish to download our free eBook, "How to Achieve Efficient & consistent Particle Size Reduction,” for additional tips.

New Call-to-action

High Pressure Homogenizers for Nanomilling for Bioavailability Enhancement

Posted by David Shechter on Jul 16, 2021 2:25:24 PM

unspecified_1Approximately 50% - 90% of existing and potential new drugs are poorly soluble. It’s a statistic with dramatic implications, since poor solubility inhibits the absorption of a drug’s active pharmaceutical ingredient (API), which renders less beneficial effects for the patients who wish to use them and less profitable results for the companies that try to sell them. Recent advancements in pharmaceutical development processes, however, indicate that using high pressure homogenizers for nanomilling dramatically improves the bioavailability of active drug ingredients, thus benefiting individuals and drug companies alike. Take a look:

What is Nanomilling for Bioavailability?

Drugs work better when they have a large surface area available for solvation. Think about a sugar cube dissolving in a cup of tea: a crushed cube will diffuse throughout the cup quicker than a lump. In much the same way, a drug whose active particles have been reduced to their smallest uniform size will disperse throughout the body better than a drug with larger particles.   

Nanomilling, then, is the process by which an API is reduced to particles less than 1000 nm in size. It’s also called wet media milling, and can be effectuated via several different techniques, but we believe high pressure homogenizers (HPHs) offer the most advantages when nanomillling for bioavailability. Here’s why:

High Pressure Homogenizers Minimize Contamination

High pressure homogenizers apply constant pressure to a product to break it into uniformly-size pieces. Other types of particle size reducers (such as bead mills, for example) use an actual grinding material (i.e., beads) to the facilitate particle reduction, agitating this material along with the product so that the product itself breaks apart. We believe HPHs, particularly those with BEE International’s propreitary pressurized pumping system, are far superior to bead mills and other wet media milling technologies specifically because they don’t introduce any foreign materials into the particle reduction process — just high pressure and the active pharmaceutical ingredient —  thus, posing little to no risk for contamination.

High Pressure Homogenizers are Faster

High pressure homogenizers supply a very intense and focused energy that enables quicker particle reduction than other processing methods. They are also highly efficient, enabling optimal particle size in the fewest passes, saving valuable production time and getting drugs — that actually work! — more quickly into the hands of the patients who need them!

High Pressure Homogenizers Allow for Targeted Particle Reduction

Because BEE International’s HPHs utilize a modular system that combines pressure, shear, cavitation and impact, many different configurations can be set up, each according to the specification of the product at hand. This means operators can customize their processes so that the exact particle size needed is produced during each run.

High Pressure Homogenizers Are Consistent and Versatile

The unique combination of forces used in BEE International high pressure homogenizers produces a tighter, more uniform distribution of particles and can be used for both inline and batch processing.

High Pressure Homogenizers Yield Scalable Results

The most beneficial type of processing equipment allows operators the ability to progress from the laboratory to production with no loss of reliability or efficacy. High pressure homogenizers allow customization of the particle size reduction process according to product volume so that the chemical integrity of active ingredient(s) is always the same.

High Pressure Homogenizers Are Easy to Clean

Finally, unlike bead mills and other types of homogenizers, high pressure homogenizers do not require manual cleaning. Inline cleaning processes permit routine (and nearly) hands-free maintenance that is not available with other nanomilling options.

Want to Learn More?

Utilizing high pressure homogenizers for nanomilling for bioavailability enhancement allows companies to produce more effective drugs and people the opportunity to take them. To learn more about what makes BEE International high pressure homogenizers the superior choice when nanomilling for bioavailability enhancement, please contact our team today.


You might also wish to download our free eBook, “Advantages of BEE Homogenizers for the Pharmaceutical Industry,” for additional information.

New Call-to-action

What’s the Best Way to Lyse Bacterial Cells?

Posted by David Shechter on May 28, 2021 9:10:46 AM

the-benefits-of-a-laboratory-homogenizer-for-cell-lysisCell lysis is the process by which a cell’s membrane is ruptured so that the cell’s contents are released. It can occur naturally (such as when certain viruses cause infections that lead to cell rupture and death) or it can be induced artificially. In addition to scientists who wish to study and experiment with intracellular contents, and thus, must be able to control the cell lysis process, there are multiple industries (including, but limited to, the pharmaceutical, biotech, food and chemical industries) that need to lyse cells in order to make products. To ensure their products’ safety, quality and efficacy, these industries must intentionally disrupt cell membranes according to their own standards instead of waiting on any natural lysis sequences that mayor may not occur. Indeed, one of the most critical components of any manufacturing process is ensuring safety, removing all potentially harmful substances so that the wellness of consumers is always protected. To this end, many industries use artificial cell lysis to remove pathogens, of which some of the most frequently occurring are bacterialcells. The question then becomes: what’s the best way to lyse bacterial cells, essentially killing them and rendering them incapable of causing illness and disease? Here’s the short answer:

Bacterial Cell Lysis is Best Facilitated by BEE International High-Pressure Homogenizers 

While there are several ways to artificially lyse cells (sonication, chemical lysis and traditional homogenization, to name a few examples), there is only one method that is capable of lysing all cell types (including bacterial ones) and that is high-pressure homogenization. Specifically, our high-pressure homogenizers here at BEE International incorporate a patented Emulsifying Cell (EC) technology that combines shear, cavitation and impact forces so that the high-pressure homogenizing process always renders optimal results. Whether used in research, pilot or industrial settings, BEEI high-pressure homogenizers ensure the best processes for bacterial cell lysis because they:

  • Provide accessibility of intracellular proteins for extraction and solubilization.
  • Disrupt all cell types since users can alter pressure, flow and processing time, as well as the amount of cavitation, shear and impact forces, to get the best results for the type of cell they are disrupting.
  • Offer flexibility, allowing easy adjustment for different cell disruption strategies.
  • Deliver high yields in less time, which lowers Total Cost of Operation (TCO).
  • Possess scalable technology, which enables users to elevate from laboratory scale to pilot scale, while achieving reproducible results.
  • Support various sample sizes and permit users to adjust the widest variety of mixing forces.
  • Require minimal training and are easy to use, reconfigure, clean and maintain.

 

Want to Learn More?

To learn more about high-pressure homogenization and why it is the best method for bacterial cell lysis, please contact our team at BEE International. We believe our equipment offers superior quality and provides the best value for researchers and manufacturers alike. Our proprietary processes guarantee that our customers produce high cell rupture yields in the shortest amount of time across the widest variety of cell types. 

You might also wish to download our free eBook, “7 Key Factors to Consider When Choosing a Cell Lysis Method,” for additional information bacterial cell lysis.

New Call-to-action

Why Homogenizers are Essential to CBD Processing

Posted by David Shechter on Jun 30, 2020 10:00:00 AM

CBDFor many business leaders, the CBD industry represents an exciting investment opportunity. Indeed, one major player opened 70 new CBD store locations in 2019 alone. And experts predict that the industry as a whole will continue to grow over the next few years. However, it’s important that businesses involved in CBD processing and the manufacturing of products like lotions, edibles, and extracts understand how to ensure efficient and uniform production standards. This is crucial for business reputation, customer satisfaction, and ROI. Here, we’ll explain why high-pressure homogenizers are essential to this process, and how CBD-based companies can benefit from using them: 

Cannabinoids

Cannabinoids are the chemical compounds found within the cannabis plant. Crucially, they represent the active ingredient in CBD products. In order to create a CBD product, manufacturers harvest cannabis flowers, reduce them to first unrefined and then refined oils, and then process the oil into a single compound known as cannabinoid isolate.  

The problem at the next, and final, stage of the process is that cannabinoids are hydrophobic –– meaning that they don’t mix with water. So it can be very difficult to evenly and efficiently incorporate cannabinoids into a finished CBD product. 

As such, CBD manufacturers must use emulsifiers to create oil-in-water emulsions involving cannabinoids. From there, they are able to form micro-emulsions, nano-emulsions, or liposomes, which are effectively combinations of hydrophobic and hydrophilic materials. Ultimately, this enables effective mixing of CBD and non-CBD compounds within a given product.

How Homogenizers Work

Generally speaking, the quality of an emulsion depends on the quality the mixing method employed. This is where high-pressure homogenizers stand above other mixing options. Most mixing equipment uses all of the three following methods to form stable emulsions: 

  • Impact –– high forces applied over a short period of time.

  • Slice/Tear ––  motion between adjacent layers of liquid.

  • Cavitation –– rapid pressure changes. 

High-pressure homogenizers are unique in that they employ all three methods at the same time. This ensures effective particle-size reduction –– a crucial aspect to quality control and production in any mixture. The smaller the particles are, the more even the mixture is and the higher its bioavailability becomes. 

Benefits to Using Homogenizers for CBD Processing

Because homogenizers so effectively emulsify and mix CBD substances, businesses are able to guarantee quality control every time they produce a new batch of products. The homogenization process eliminates “hot spots” –– or collections of CBD compounds within a mixture –– thus creating evenly distributed mixtures every time. 

What’s more, high bioavailability maximizes the potency of CBD products. So businesses are able to deliver high-quality products while using lower amounts of active ingredients. Bolstered bioavailability also contributes to faster-acting CBD products, and more stable CBD products that have a longer shelf-life. All told, high-pressure homogenizers can increase bioavailability by up to 75%.

In summation, using homogenizers to complete CBD processing boosts ROI, reduces costly inefficiencies, creates high-quality, potent, long-lasting products, and –– in all likelihood –– will improve customer satisfaction as well. 

Contact Us

BEE International has been a leading provider of high-pressure homogenization solutions for decades. Not only is our equipment cutting-edge and versatile, but we’ve also added cannabis-specific innovations to our process based on customer feedback. For more information, you can check out our eBook on cannabis products. Or, to get started with us today, contact us here.

download cannabis ebook