Tal Shechter

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What’s the Difference Between Solutions, Suspensions and Colloids?

Posted by Tal Shechter on Sep 26, 2019 9:00:00 AM

Thoughtful businessman looking at three arrows drawn on chalkboard-474958-editedMany industries use homogenizers as part of their manufacturing processes. Companies (cosmetic, food, chemical and pharmaceutical, to name but a few) need homogenizers to mix together the elements of their products. Effective mixtures not only have a better viscosity, consistency, texture, flavor and/or appearance (depending on the end product’s use), they create a stability within the product that extends shelf life, as well as increases bioavailability and efficacy (when applicable). This ultimately saves businesses of all types both time and money. In order to understand how homogenizers can facilitate all these advantages, however, it’s first necessary to learn about “mixtures.” Contrary to what might seem apparent, the word “mixture” can mean a lot of different things. Read on for a simple explanation of the difference between solutions, suspensions and colloids — all of which can be accurately classified as mixtures!

 

Mixtures Are Either Homogeneous or Heterogenous      

Chemically, all matter is either a pure substance (an element or compound) or a mixture of two or more elements and/or compounds. Furthermore, mixtures can either be homogeneous or heterogenous. A homogeneous mixture is uniform in its composition, meaning that no matter how you divide it, it will always display the same properties. For example, air is homogeneous mixture of several separate gases (N2, O2, H2O, and CO2); any volume of air will always contain the same ratios of its component gases.

All homogeneous mixtures can also be called solutions, composed of the solvent (the component of the substance that exists in the greatest amount) and one or more solutes (those components that exist in smaller volumes). In essence, solutes are “dissolved” in the solvent, making it impossible to identify either. And while water is the most evident solvent, other gases, liquids and even solids can be solvents, too.

A heterogenous mixture, on the other hand, is not uniform in composition; it’s a combination of two or more substances, like sand. Sand, when viewed under a microscope, will display an uneven distribution of particles, meaning no one handful will contain the same ratio of individual parts.

 

Heterogeneous Mixtures Can Be Further Separated Into…

All homogeneous mixtures are solutions, but heterogenous mixtures can be split into two separate categories: suspensions and colloids.

Suspensions are heterogenous mixtures where the individual components of the substance can be physically observed (when left to settle). Think about how many oil-based salad dressings separate into two layers in a bottle. Or how a bit of dirt in a glass of water eventually falls in a layer of silt at the bottom. These are all examples of suspensions.

Colloids are also heterogenous mixtures of particles, but the particles in colloids are significantly smaller than those found in suspensions — only 1 to 1,000 nanometers in diameter. Although these particles are very tiny, they remain larger than those found in homogeneous solutions and generate a tell-tell opaque appearance when light is applied to them. Indeed, colloids are often differentiated from solutions via the Tyndall Effect, the scattering of light that occurs when a light beam encounters the particles within a heterogenous mixture. If a beam cannot pass through a substance but rather bounces off it, you know that there are individual particles suspended in that substance reflecting the light, thus making it either a colloid or a suspension. Some examples of colloids include milk, mayonnaise and butter.

 

BEE International: The Clear Choice for High-Pressure Homogenizers

The effective mixing of components determines the value of many different types of products. Homogenizers, especially quality high pressure homogenizers (HPHs), create stable solutions, suspensions and colloids that can be used for a variety of purposes. If you would like to learn more about homogenizers and the specific benefits of a BEE International high pressure homogenizer, please contact us today!

You are also welcome to download our free eBook, “How to Achieve Efficient & Consistent Particle Size Reduction,” for additional insight on the benefits of consistent particle size reduction.

 

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5 Benefits of Developing a Cannabis Product with High Pressure Homogenizers

Posted by Tal Shechter on Mar 15, 2019 2:12:00 PM

Developing Cannabis Products with High Pressure HomogenizersThe legalization of cannabis use in places like Canada and many U.S. states over the last few years is changing the way cannabis manufacturers make their products. To remain competitive in a burgeoning market, they are being forced to differentiate themselves in some way. The smart ones are simply making superior products. More than snazzy marketing, quality products encourage trust between consumer and company that often translates into repeat sales. One of the best ways cannabis manufacturers can insure their products’ superiority is by using a high pressure homogenizer (HPH) during the manufacturing process. Long considered a necessity in many food, pharmaceutical and chemical applications, HPHs offer the best solution for particle size reduction and uniform mixing. Take a look at why cannabis manufacturers believe this matters:

Increased Bioavailability

High pressure homogenizers are adept at breaking apart substances. And our patented BEE International homogenizers compound this efficiency with specialized cannabis-specific homogenizing agents that reduce cannabis particle size even further. Breaking the cannabis into the smallest pieces possible maximizes the surface area of the cannabis as a whole, which increases the rates of dissolution and absorption (i.e., the bioavailability) of the active ingredient by up to 75%.

Reduction of Active Ingredient Amount

Increased bioavailability also means less active product is needed for the same effect. Because high pressure homogenizers reduce cannabis particles and mix them together so well, the final cannabis product is uniform throughout the whole of its composition, ameliorating disparate concentrations of its active ingredient and allowing maximized absorption to occur. If there’s more active ingredient being absorbed, you don’t need to use as much.

Reduction of Response Time

Similarly, HPHs reduce the amount of time it takes for cannabis products to take effect. They create such small particles of active ingredient that are easier to dissolve. And faster dissolution equals faster response.

Increased Shelf Life

High pressure homogenizers create more stable mixtures than lower shear mixers. They so effectively combine particles that the particles don’t separate, even after a certain amount of time. Thus, you can store cannabis products that have been homogenized using high pressure longer and still remain confident of their stability and their efficacy.

Better Appearance and Taste

Finally, high pressure homogenizers ensure that cannabis products always look and taste the same. When ingredients are properly combined, you can’t differentiate their individual parts. Cannabis-infused lotions will appear smoother and more homogenous, and edibles will be uniform in texture and test. These are all important qualities. If manufacturers create products that always look and smell and taste the same, then consumers can trust them with each and every purchase, making it easy to come back for more.

Need More Information?

High pressure homogenizers enable the precise particle size reduction and mixing of many types of substances. They are especially beneficial for cannabis manufacturers who need to guarantee the potency, consistency, efficacy and appearance of the products they make. Our patented and proprietary high pressure homogenizers here at BEE International allow for automated and continuous operation and feed. Our machines are sanitary and temperature-controlled with the capacity to immediately scale up or add secondary products. If you need help determining the best high pressure homogenizer for your own processes, contact our team. We can help you match the right product to your needs.

To learn more about CannaBEE, download our free eBook, “3 Reasons Why High Pressure Homogenization Improves Cannabis Products." In it, we provide information about our customized homogenizing solutions specifically designed for the cannabis industry. 

 

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What Makes a Great Homogenizer Manufacturer?

Posted by Tal Shechter on Feb 18, 2019 2:45:58 PM

homogenizer manufacturerThere are over a hundred homogenizer manufacturers in the U.S. alone. Choosing the right one depends on your understanding of what you really need and a manufacturer’s ability to deliver it. Here’s a quick look at six features that great homogenizer manufacturers should always guarantee:

  • Consistency


It should go without saying: a great homogenizer manufacturer has a proven track record of producing high-quality machines that yield the same results time after time. Homogenizers aid processes across several industries, many of which manufacture life-altering products; companies in the pharmaceutical, food, chemical and biotechnological sectors, especially, rely on homogenizers to process products that are reliable and accurate every time.

  • Scalability


In addition, results should always scale-up from initial testing to meet final manufacturing demand. Great homogenizer manufacturers verify that their equipment produces the same results regardless of product load.

  • Efficiency


Great homogenizer manufacturers also ensure that their machines are efficient, creating a product in the fewest number of passes and/or offering accessories that improve laboratory, pilot and industrial operations when needed. The ability to customize their homogenization processes is especially important for businesses wanting to maximize budgets and save time.

  • Durability


Businesses need equipment that is durable, continuing to operate at full capacity for the longest time possible. Homogenizer manufacturers must create machines that are easy to clean, maintain and repair.

  • Safety and Security


With changing regulations and mounting privacy concerns, it’s more important than ever that businesses safeguard both their operators and their practices. Homogenizer manufacturers should implement safety features into their equipment and provide homogenizer software that is secure, programmable and responsive, assuring the privacy of data and alerting operators when maintenance needs or other issues arise.

  • Testing, Installation and Training


Finally, great homogenizer manufacturers allow opportunities for the testing of equipment before purchase and deliver ongoing customer service afterwards. A relationship with a homogenizer manufacturer should extend far beyond point of sale with warranties and support offered throughout the life of the machine.

 

Are You Ready to Learn More?

At BEE International, our patented Emulsifying Cell (EC) technology enables our homogenizers to deliver reliable, scalable results. Using multiple forces (rather than the usual one of many other homogenizer manufacturers), our equipment effectively enables high pressure pasteurization and ruptures cells, reduces particle size and creates dispersions and micro/nano emulsions. Researchers and manufacturers around the world trust our products to make everything from life-saving medicines to soup. Contact us to learn more about the other features that set us apart from the competition, making us the right homogenizer manufacturer for you, too. 
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Homogenization and the Industries That Use It

Posted by Tal Shechter on May 29, 2018 2:00:00 PM

bee2Many people go to a local store to buy food, personal care products, medicine and other items. However, most of us don’t spend any time considering what went into the production of these items. In many cases, it likely involved homogenization.

Homogenization is a process utilized for particle size reduction. It works by forcing a sample through a narrow space, and multiple forces, including turbulence and cavitation in addition to high pressure, can act on the sample to create a high-quality product. It can be used on many different types of material, such as plant, food, soil, tissue and more. Plus, it provides benefits for multiple applications, such as high-pressure pasteurization, dispersions, micro/nano emulsions and cell disruption.

Although many other types mixing machines exist, homogenizers are scalable, and their use of multiple mechanical forces instead of just one results in stable, uniform and consistent products. They are used in a wide variety of research and scientific uses and by many industries that require the use of active ingredients because they reduce active ingredients to a small enough size to ensure a thorough dispersion throughout the medium produced.

Pharmaceutical

Powerful mixing and particle size reduction are key techniques among pharmaceutical products. In the pharmaceutical industry, researchers use homogenizers during laboratory research and in clinical trials and manufacturing for products including vaccines, antibiotics, cancer treatment and medicinal creams. Benefits of homogenization for pharmaceutical products include improve delivery of active pharmaceutical ingredients, increased digestibility, lengthened shelf life and improved reliability in manufacturing settings.

The most important uses for homogenizers in the pharmaceutical industry are particle size reduction, scaling for drug development and synthesis of essential drug components. Though other mixing methods exist, homogenization is the most scalable, resulting in increased cost savings, lower time requirements and a decrease in the likelihood of failure for the product for which its used.

Food and Beverage

Many people identify the use of homogenization in the food and beverage industry with milk; it gives milk a longer shelf life and makes it more stable and visually pleasing. Homogenization is primarily used in the food and beverage industry to help manufacturers improve the composition and quality of their products and ensure their end products meet standards for visual appearance, texture and taste. 

Because homogenization utilizes pressure instead of heat, valuable nutrient content and flavor are preserved, chemical structures are stabilized and food processing outcomes are improved. It is a preferred method for producing emulsions, suspensions and other products that require a liquid suspended in another liquid or a small particle size. These products include mayonnaise, ice cream, cream liqueurs, salad dressings, dairy products and more.

Biotech

The biotech industry is comprised of the fields of cellular biology and molecular biology. Homogenizers are most commonly used in this industry to achieve effective cell rupture, enhanced particle size reduction and nanoparticle production. Although they decrease particle size, they ensure that a composition is equal throughout without compromising the overall molecular makeup of the sample.

Homogenizers also can be used to create cost effective medicines, modify microorganisms, synthesize new chemicals and develop alternative biofuels. In the case of cell disruption, they allow for a variety of cells, including E. coli, yeast, bacteria and delicate animal tissues, to be ruptured to recover the contents of essential cells.

BEE International: First on the Road to Reliability

BEE International offers homogenizers that are both high-quality and reliable. Our line of equipment is suitable for virtually every industry and can work in just about any environment. Contact us today to learn how our products can maximize your homogenization processes.

To learn more about 7 key factors to consider when choosing a cell lysis method, no matter the industry you're in, download our FREE eBook:

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Suspension vs. Colloid: How Do They Differ?

Posted by Tal Shechter on Dec 20, 2017 11:30:00 AM

suspension vs colloidAs we’ve outlined in recent blogs, homogenization is a process utilized for particle size reduction and works by employing mechanical force to break down particles or droplets in a liquid into smaller and more uniform sizes. The result of homogenization is a dispersion, wherein fine particles of one substance are scattered throughout another substance. Furthermore, dispersions are able to be classified by the sizes of these scattered particles: solutions, suspensions and colloids. In this blog, we’re focusing on the difference between suspension and colloids.

Suspensions

Simply defined as a heterogeneous mixture of two substances in which one is dispersed into the other, suspensions involve particles larger than those found in solutions, typically over 1,000 nm. The bigger particles of a suspension usually settle or separate out of a mixture upon standing or are able to be filtered out, although not through filter paper. Gravity is able to pull the visible particles in a suspension down if undisturbed, and they will stay that way unless being actively mixed. Examples of suspensions include oil and water, dust or soot in air, sand and water and muddy water.

Colloids

Although a heterogeneous mixture of two substances like suspensions, colloids involve particles from 1-1,000 nm that do not separate upon standing and cannot be separated by filtration. The particles in a colloid land in size between those in a solution and a suspension and may be solid, liquid or gas. The two parts in every colloid mixture are its particles and the dispersing medium, and the particles are spread evenly in in the medium, which can also be solid, liquid or gas. Examples of colloids are foams (shaving cream, Styrofoam), gels (gelatin, jelly), emulsions (mayonnaise, lotion), aerosols (fog, insecticide spray, smoke) and sols (shampoo, gemstones).

Even though the particles in a colloid are very small in size, they can be seen through a process called the Tyndall Effect, the effect of light scattering in colloidal dispersion while showing no light in a true solution. This effect is used to determine whether a mixture is a true solution or a colloid.

Colloid mills, like homogenizers, are able to process particle reduction formulations, although each is preferential for certain applications. They are best used for samples comprised of solids immersed in a liquid suspension or a liquid suspended in another liquid because they can enhance the stability and/or reduce the size of suspended particles.

Overview

In summary, following are some of the main differences between a suspension and colloid:

  • Particles in a suspension are usually more than 1,000 nm, while those in a colloid range from 1-1,000 nm.
  • Unlike those in a suspension, particles in a colloid do not separate when sitting still.
  • The particles in a suspension may be separated by filtration unlike those in a colloid.
  • Colloids are able to scatter light, but suspensions cannot transmit light.
  • Particles in a suspension can be seen by the naked eye, but those in a colloid must be viewed using a light microscope.

BEE International: The Clear Choice for High-Pressure Homogenizers

At BEE International, we not only offer a multitude of high-pressure homogenizers to handle almost any task in a laboratory, pilot plant or industrial setting, we help you sort through the technical jargon to find equipment that best addresses your specific needs. Our line of equipment is suitable for virtually every industry and can work in just about any environment, letting you focus on other important projects. To learn more about our technology and products, please contact us today!

If you’re interested in learning more about how you can break down particles in the best way possible, download our free eBook “How to Achieve Efficient & Consistent Particle Size Reduction” today:

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How Do Inline Mixers Work Differently Than High-pressure Homogenizers?

Posted by Tal Shechter on Dec 1, 2017 11:30:00 AM

inline mixersWhen they hear the term “homogenization,” many people think of milk. In fact, one of the first applications of homogenization came in the processing of milk. Derived from the Greek word “homogenos” (homos meaning same and genos meaning kind), it is defined as the process of reducing the particle size of an object and is also known as micronization.

Homogenization works by forcing a sample through a narrow space through multiple mechanical forces, thereby producing a stable and consistent product. Easily scalable, it is used by multiple industries, including pharmaceutical, biotech, cosmetic and food, in order to optimize their finished product.

Under the umbrella of homogenization lie two different methods: inline mixing and high-pressure homogenization. Read on to learn the differences between how the two work and advantages associated with each.

Inline Mixing  

Positioned within the production line and aligned with the flow of product, inline mixers consist of a stationary stator and an inside rotor that turns at high speeds. The rotor–stator device is contained in a casing with an inlet at one end and an outlet at the other, and the rotor is driven through a seal. Mixing occurs when a sample is drawn in through one of the mixing heads while the blades rotate and is then expelled at a high velocity through an opening in the stator. The inline term comes into play around the mode of sample entry into the mixing chamber.

Inline mixers feed and output material in a continuous stream, allowing material to often be perfectly hydrated, emulsified or homogenized in a single pass. They differ from other types of homogenization wherein large amounts of ingredients are mixed in a standalone unit before going through the homogenization process. Designed to handle all types of tasks, including emulsifying, suspending, dispersing, blending and more, inline mixers are suitable and useful for applications where larger quantities are needed for production and continuous processing and homogenization is needed during the manufacturing process. In addition to being faster than their high-pressure counterparts, they allow for a more controlled and continuous mixing environment, improve yields, use less energy and increase capacities.

High-pressure Homogenization

Whereas inline mixers rely on rotor/stator shearing action, high-pressure homogenizers force a sample through a narrow space using force and high pressure, thereby reducing particle size or lysing cells. They consist of a high-pressure pump and a disruption unit which enable a continuous homogenization. The higher the amount of energy applied during the homogenization process, the smaller the particle size or the more complete the cell lysis. The pressure along with the action of multiple forces yields impactful results in only one or two passes. Benefits of high-pressure homogenization include consistency in composition of products, greater stability of final products and decreased cost. Also high-pressure homogenizers allow users to set operating parameters - pressure, temperature, number of passes, valve and impingement design and flow rate – for a particular homogenization.

BEE International: Your Homogenization Equipment Headquarters

At BEE International, we offer a wide selection of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, biotech and more. Our products can help enhance your production, improve product quality and streamline your operations, all in combination with our unmatched customer service. Contact us today to learn more about our homogenization equipment and find out what product(s) is best suited to your business needs.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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What are Inline Homogenizers Used For?

Posted by Tal Shechter on Oct 30, 2017 11:30:00 PM

Business man looking at wall with a bright question mark concept-222794-edited.jpegOne important question to answer when beginning any manufacturing project requiring homogenization, micronization, or particle size reduction is an obvious one: what is homogenization, and what are homogenizers used for? Finding out the answers to these two important questions is an important first step in determining the type of homogenizer to purchase and ultimately use.  Various types of homogenizers exist, all with a multitude of pros and cons. In this article, we will focus on discussing one especially popular type of homogenizer -- the Inline Homogenizer.

Inline Homogenizers are designed to handle all types of tasks, including emulsifying, suspending, dispersing, and blending. These homogenizers are used in a variety of industries, including pharmaceutical, cosmetic, biological, and chemical. What makes inline homogenizers unique? One key feature is the fact that they are positioned within the production line, aligned with the flow of product.  Inline homogenization is different from other types of homogenization, such as batch homogenization, where large amounts of ingredients are mixed in a standalone unit before going through the homogenization process.

Inline homogenizers are suitable for applications where larger quantities are needed for production. Since they are able to be installed right on the production line, they are especially useful for applications where continuous processing and homogenization is needed during the manufacturing process.

The benefits of inline homogenization are endless. Not only is inline homogenization a faster process, especially in situations where larger quantities are being produced, it is also a more economical option, since additional mixing tanks and vessels are usually not needed. Inline homogenization also ensures consistency throughout a production run, since homogenization is occurring continuously on the production line.

BEE International offers a wide variety of inline homogenizers to meet the need of virtually any industry. Our Laboratory, Pilot and Industrial Homogenizers are suitable for all production needs, from small scale R&D applications up to full scale, 24/7 industrial operations. Our DeBEE 4000 homogenizer offers the following features and benefits:

  • Complete Automation, Compliance, and Production Capacity of 120 LPH and up
  • Multiple Vertical Process Intensifiers
  • An advanced, user-friendly interface
  • CE Compliant
  • Pharma/Bio/Food Sanitary
  • Synchronized Pump System for Constant Pressure
  • Advanced Data Collection and Gathering
  • Clean in Place (CIP)
  • Programmable Maintenance Schedule with Alarms
  • In-line Spare Intensifier
  • User Management
  • Data Trending

For more information on the Inline Homogenizers in our assortment, as well as our full suite of homogenization equipment, please contact us. We are looking forward to assisting you with your next homogenization project!

Need to Efficiently & Consistently Reduce Particle Size In-Line?

Many of our manufacturing partners that use inline homogenizers need to reduce the particle size of their application in order to pass it on to the next processing stage. With a variety of particle size reduction techniques, including homogenization, how can you find the best method? Check out our free eBook “How to Achieve Efficient & Consistent Particle Size Reduction” and learn which method is best for you:

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3 Advantages of Homogenizers for the Pharmaceutical Industry

Posted by Tal Shechter on Aug 23, 2017 11:30:00 AM

homogenizer for pharmaceuticalHomogenization – also known as cell fractionation or micronization – is the process of dividing particles into microscopic sizes, ranging anywhere from 0.5 microns to 2 microns, depending on the application. Homogenizers play an important role in the pharmaceutical industry, and are commonly used for dispersions, emulsions, particle size reduction, and cell rupture.

Keep reading to discover the advantages of homogenizers for pharmaceutical products in the ever-growing pharmaceutical industry.

1. Reduced Particle Size

Effective homogenization results in a smaller particle size and more even distribution of active ingredients. For topical pharmaceutical products, such as medicated creams, lotions, and ointments, this allows for those medications to absorb more rapidly into the skin. A reduction in particle size increases the surface area of critical (and often expensive) active ingredients, which allows for an even dispersion of the active ingredients in the product, which increases efficacy of pharmaceutical products and lowers cost as well.

2. Increased Stability of Pharmaceutical Products

High-quality homogenizers have the ability to reduce the particle size of critical active ingredients, which in some cases can help improve the stability of these otherwise unstable active ingredients. Some critical active ingredients used in the pharmaceutical industry are solid at room temperature, and only moderately soluble in water or organic solvents. Effective homogenization can reduce these otherwise difficult to work with active ingredients into a small enough size that they have increased solubility in these mediums, many of which can work further to increase the shelf life and stability of the active ingredients.

3. Increased Reliability in Manufacturing Settings

BEE International has a number of first-class homogenizers that can meet the needs of manufacturers in the pharmaceutical industry. Our industrial homogenizers are designed for cGMP manufacturing, and offer reliability suitable for all industries, including those with a 24/7 operating schedule. Our proprietary software offers touch screen guided operation, data collection, security, on-line maintenance schedules and alarms, and configurable recipes and capacities.

BEE International industrial homogenizers and high pressure homogenizers are manufacturing pharmaceutical, chemical, life sciences, food, cosmetic products, and more. Contact us today to discuss the benefits our homogenizers can bring to manufacturing your company’s products. You can also download our free eBook, “Advantages of BEE Homogenizers for the Pharmaceutical Industry” here.

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Local vs. Systemic Steroids: What's the Difference?

Posted by Tal Shechter on Jun 13, 2017 2:30:00 PM

Local vs. Systemic SteroidsWhen most people think of steroids, images of elite athletes using synthetic hormones to gain a competitive advantage may come to mind. However, steroids – more often referred to as corticosteroids in medical circles – are often used to serve a very different purpose. There are numerous varieties of corticosteroid medications, including cortisone, methylprednisolone, and prednisone.

Steroids work by both reducing inflammation and decreasing immune system activity, and they are commonly used to treat a variety of diseases, including rheumatoid arthritis, eczema, asthma, and a host of other inflammatory ailments.

Steroids come in several different forms – local and systemic.  The form of steroid used is dependent on the ailment that is being treated, as well as the desired outcome.

Local steroid medications are best suited for ailments where a targeted approach is desired. These types of steroids can be introduced directly to the area in question and include eye drops, ear drops, skin creams, and joint injections.

Systemic steroids are best suited for ailments that require treatment throughout the entire body. Systemic steroids circulate throughout the bloodstream and reach every area of the body. They include oral medications as well as medications that are delivered intravenously or intramuscularly.

For both local and systemic applications, homogenization is an important process step to consider in industries that manufacture steroid-containing topical creams, ointments, and intravenous drugs.

In all applications, the even dispersion of active ingredients is critical to ensuring efficacy and decreasing manufacturing costs. Oral medications, for example, require homogenization and micronization of particles to ensure consistency throughout the product. Similarly, systemic steroids require the use of a homogenizer to ensure even dispersion and dissolution of the particles that make up the active ingredients.

BEE International offers a number of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, and biotech. Our homogenizers can meet the needs of virtually any environment – from small R&D settings and pilot plant operations all the way to 24/7 manufacturing environments.

For small sample sizes, as are often seen in laboratory and R&D settings, our Nano DeBEE is an excellent choice. This mechanical homogenizer uses multiple forces, including cavitation, turbulence, and pressure to create microscopic particles that can easily be dissolved in a variety of mediums, including liquids, creams, and organic solvents.

Contact us today to discuss the numerous benefits our homogenizers can offer to manufacturing your company's products. 

Also, be sure to check out our FREE eBook on how to achieve efficient and consistent particle size reduction

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Choosing the Right Pilot & Industrial Homogenizer

Posted by Tal Shechter on Apr 18, 2017 12:30:00 PM

choosing right pilot and industrial homogenizerHomogenization, also known as particle size reduction or micronization, is a technique that is widely used across a number of industries: cosmetic, food, pharmaceutical, and biotech. This powerful (and useful) technique allows manufacturers to create uniform creams, visually pleasing sauces, and effective pharmaceutical painkillers, just to name a few applications. And without the innovative technology found within homogenizers,  few of the aforementioned products would be as readily available as we’ve come to expect.

With that, it is no surprise that the task of choosing the right homogenizer for the job is an often daunting task. With so many options on the market to choose from, it is easy to get overwhelmed. However, if certain key points are kept in mind, choosing the right homogenizer for your pilot or industrial plant can be simple. Continue reading to learn more about the pilot and industrial homogenizers offered by BEE International.

DeBEE 2000 Pilot Plant Homogenizers

The DeBEE 2000 line of homogenizers represent the smallest available units that offer all available process configurations, including dual feed, dual jet, and automatic clean in place (CIP) technology.  These homogenizers also offer a number of powerful validation packages, as well as hazardous environment protection, feed solutions, and additional process monitoring.

DeBEE 3000 Industrial Homogenizers

The DeBEE 3000 line of homogenizers are our entry level production scale models, suitable for both laboratory work as well as scaled up production work. No matter the needs of your industry, the DeBEE 3000 line of homogenizers are suitable for your process. These homogenizers offer unmatched particle size reduction with maximum efficiency for micro/nano emulsions and particles, as well as the highest yield in cell rupture in the shortest amount of time.

DeBEE 4000 Automated Industrial Homogenizers

The DeBEE 4000 line of homogenizers represent the most powerful line of homogenization equipment that BEE International has to offer. This series of equipment offers the highest levels of process controls and automation, as well as integration with plant controls and compliance with CFR 21 part 11 requirements. In addition to other powerful benefits, these homogenizers offer various security modes and authorizations, alarms to ensure system safety and the correct course of action, SCADA compliance, and sanitary design and features suitable for even the most stringent of fields.

To learn more about the line of homogenizers offered by BEE International, please contact us today. We look forward to working with you on your next homogenization project.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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