Tal Shechter

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How the DeBEE 2000 Can Benefit the Manufacturing Process

Posted by Tal Shechter on Mar 23, 2017 12:30:00 PM

DeBEE 2000Homogenization is used in a number of important industries, including cosmetic, food, pharmaceutical, and biotech. This process is more simply known as particle size reduction, and occurs when a particle is made smaller. This simple act has countless benefits: increased quality of texture, taste, and appearance, tissues and particles that are more readily studied in laboratory settings, and lower production costs. With all of these benefits (and many more!) it’s no wonder that more and more industries are looking to get involved in this powerful process by purchasing a homogenizer for their industry.

However, before taking on this task, it is important to understand the options that are available. BEE International is here to help! BEE – short for Best Emulsifying Equipment – stays true to its name with a number of machines that can help with the process of homogenization. Our homogenizers are well suited for virtually any application and just about any setting, from a smaller laboratory or R&D setting, to pilot plants, all the way to large scale manufacturing plants.

One of our more popular laboratory scale models is the DeBEE 2000. What does this powerful piece of equipment do? How can it help in your industry? What benefits and features does it offer? Continue reading to learn the answers to all of those questions and more. 

The DeBEE 2000 is designed to facilitate process development in a laboratory or R&D setting.  This series includes the DeBEE 2000-45-30, DeBEE 2000-45-60, DeBEE 2000-30-60, DeBEE 2000-25-100, and DeBEE 2000-20-120 models. The technology contains a proprietary homogenizing cell that allows for unmatched results in fewer passes. The DeBEE 2000 series is also well suited to produce results that are not just repeatable, but scalable as well. Other features include:

  • Easy to clean
  • Variable operating pressure up to 45,000psi
  • Modular design for lower cost replacement parts
  • PLC control and monitoring for simple operation
  • Constant process pressure for tighter product distribution
  • Ability to control cavitation, pressure, shear, and impact
  • Adjustable back pressure
  • Stainless steel enclosure
  • Dual feed
  • Dual jet
  • Automatic Clean in Place (CIP)

To learn more about the DeBEE 2000, as well as how we at BEE International can help with your next homogenization project, please contact us today. Our free product guide that explains more of the features in detail is available for download here.

For more information on how to achieve efficient and consistent particle size reduction results, download our FREE eBook:

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Sonication Cell Lysis: How Does it Compare to Homogenization

Posted by Tal Shechter on Mar 9, 2017 12:30:00 PM

sonication cell lysisHomogenization, also known as micronization or particle size reduction, is an important process step that is utilized in a variety of industries, including pharmaceutical, biotech, cosmetic, and food. With benefits like improved taste, texture, and appearance, its no wonder that more and more industries are looking to purchase a homogenizer for their manufacturing needs!

However, before purchasing your next homogenizer, it is important not only to know what your desired end use is, but the capabilities of the homogenizers in today’s marketplace. One question that is frequently asked regards the capabilities of homogenizers versus a sonicator. If you are interested in learning more about sonication cell lysis and how it compares to homogenization, you are in the right place! Continue reading to learn more about sonication cell lysis, how it compares to homogenization, and what BEE International has to offer in the way of high quality, high pressure homogenization equipment.

Sonication is defined as the act of applying sound energy to agitate particles in a sample. It is used for various purposes, including cell lysis, and it is a very powerful technology with both chemical and physical effects. Sonication serves multiple purposes, and is often used for the production of nanoparticles, such as nanoemulsions, as well as nanocrystals, liposomes, wax emulsions, and extractions of compounds such as plant oils and antioxidants.

Sonication works to lyse cells very quickly, with most methods taking between 15 seconds and 2 minutes. The intensity of sonication is quite easy to adjust, allowing for gentle or abrupt disruption of cell membranes. The temperature and length of sonication can also be adjusted.

Homogenization, on the other hand, involves the forcing of cells or tissue suspensions through a narrow space, which shears the cell membranes. Due to the high pressures associated with homogenization, fewer passes are needed to completely disrupt the cells, making homogenization a quicker (and oftentimes easier) choice for the lysing of cells.

BEE International offers a variety of homogenization equipment to suit virtually any need. Our homogenizers are suitable for laboratory and research & development use, as well as pilot plant and industrial use. Our homogenizers also offer the following features and benefits:

  • Easy to clean with CIP (Clean in Place) technology
  • Variable operating pressure from 5,000-45,000 psi
  • Modular design for lower cost replacement parts
  • PLC control and monitoring for simple push-button operation

Please contact us today to learn more about the homogenization equipment that we have to offer. We look forward to working with you to optimize the homogenization process for your industry.

For more information on cell lysis methods and how to choose the right one, download our FREE eBook:New Call-to-action

Microemulsions as a Drug Delivery System

Posted by Tal Shechter on Mar 7, 2017 12:30:00 PM

drug-delivery.jpgHomogenization, also known as particle size reduction, is a technique that is gaining popularity in numerous industries, including pharmaceutical, cosmetic, and food. In the pharmaceutical industry, where production of drugs, antibiotics, and other essential medications are paramount to the success of the industry, it is important to understand one important concept: microemulsions. To learn more about microemulsions – what they are, how they work, and how they are critical to the success of the pharmaceutical industry – continue reading.

Microemulsions are defined as clear, thermodynamically stable, liquid mixtures of oil, water, and a surfactant – a compound that lowers surface tension. While the aqueous phase of a microemulsion may contain salts or other ingredients, the oil phase is often a mixture of olefins and hydrocarbons. Microemulsions form upon mixing of the components, and do not require the high shear that is often necessary in the formulation of typical emulsions.

Microemulsions have a number of important uses, including (but not limited to) the following applications:

  • Water-in-oil microemulsions for dry cleaning processes
  • Floor polishers and cleaners
  • Personal care products such as creams and lotions
  • Pesticide formulations
  • Drugs

Microemulsions also have other applications, including the creation of polymers. During this process, the transport of free radicals, monomers, co-surfactants, inhibitors, and other species occurs across the aqueous and organic phases of a system.

In the world of drug delivery, self-microemulsifying drug delivery systems, which can be described as isotropic solutions of oils and surfactants that form oil in water microemulsions when they are introduced into an aqueous medium, can improve a number of processes. For example, when presented as capsules, these drug delivery systems can improve the absorption of active ingredients within the body. In addition, with active ingredients that are not water soluble, microemulsions can help resolve that issue, making drugs, antibiotics, and other products created by the drug industry more bioavailable to the end consumer.

BEE International offers a number of homogenization equipment that can help with the formation of microemulsions. Our laboratory homogenizers, including the Nano DeBEE, Mini DeBEE, and Micro DeBEE, are well suited for this application, as well as other applications within the research and development community. Other features and benefits of our laboratory homogenizers include:

  • Maximum operating pressure of up to 45,000 psi
  • Maximum capacity of up to 400 mL/min
  • Ability to create emulsions, dispersions, and microemulsions
  • Capabilities for cell rupture and liposome work

To learn more about what BEE International has to offer, please contact us today.

For more information on cell lysis methods, download our FREE eBook:

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3 Major Benefits of Homogenizers in the Food Industry

Posted by Tal Shechter on Feb 15, 2017 12:30:00 AM

homogenizers in the food industryHomogenization, also known as micronization or, more simply, particle size reduction, is a process that is growing in popularity in a number of manufacturing industries, including cosmetic, chemical, biotech, and pharmaceutical. However, few people realize that the process of homogenization is utilized in another industry, one that affects virtually all of us – food! The use of homogenization equipment in the food industry offers a number of benefits, both to the industry itself, and to the customers, who receive the end results of the industry. Continue reading to learn more about the many benefits that homogenizers bring to the important (and ever growing!) food industry.

1. Extension of Shelf Life

One little known benefit that homogenization offers is an improved shelf life.  The process of reducing particle sizes requires the use of intense pressure, among other forces. This pressure that is exerted on food products often results in the creation of more stable chemical structures. This results in increased freshness, as well as a longer shelf life of the end product.

2. Improved Quality of Food

The process of homogenization also results in a higher quality of food. The reduction of particle size of products results in an end product that has improved taste, texture, appearance, and overall quality over its non-homogenized counterparts.

3. Food Preservation 

Related to the extension of shelf life benefit that homogenization brings is the benefit of food preservation. While heat treatment – another method of preserving food – is effective in killing harmful bacteria and microorganisms, heat can also kill helpful microorganisms, vitamins, and nutrients. Homogenization, on the other hand, uses pressure to accomplish the same task as its more destructive counterpart. This results in food that is preserved and healthy. A win-win!

BEE International Homogenizers

Homogenization offers many benefits to those in the food industry, as we now know. When searching for the right homogenizer for the job, make BEE International your first stop. We offer homogenizers for virtually every environment and application, including laboratory use, research and development applications, and, of course – pilot plant and industrial operations.  In addition, our homogenizers offer some of the following benefits:

  • Constant pressure with electronic synchronization
  • Unique CIP (Clean in Place) positioning for thorough cleaning
  • Numerous cylinder sizes available to match specific pressure, flow capacity, and product characteristics requirements

To learn more about the homogenizers offered at BEE International, as well as how we can help with the homogenization process in your industry, please contact us today.

For more information on particle size reduction and how to get efficient and consistent results, download our FREE eBook:

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How Homogenizing Cell Technology Works

Posted by Tal Shechter on Feb 13, 2017 12:30:00 PM

Homogenization, also known as micronization or particle size reduction, is an important processing step in a number of growing industries, including pharmaceutical, biotech, cosmetic, and food. This critical processing step allows for active ingredients to assimilate more readily into a number of given mediums – creams or sauces, for example – to create an ideal texture, taste, and appearance. With benefits including increased product quality, improved customer satisfaction, and lower overall cost, it’s no wonder that more and more industries are seeking to implement the process of particle size reduction in their manufacturing process.

Regardless of your industry, if you are on the market for a new piece of homogenizing equipment, BEE International has a variety of homogenizers to meet the needs of your unique industry. But before choosing the right homogenizer for the job, it is important to understand the technology behind our powerful homogenizing equipment.  For us at BEE International, that technology begins with our powerful homogenizing cell technology. Continue reading to learn more about this powerful technology and how it helps our homogenizers soar to the top of their class.homogenization cell technology

BEE Emulsifying Cell

At the heart of the homogenizing technology at BEE International, our patented EC – or emulsifying cell – can be found. This EC is a powerful tool, equipped with a number of unique and customizable options. The EC utilizes a number of mechanical forces, including shear, cavitation, and impact, to optimize new and improved products in the world of manufacturing. The EC is a modular device that can be setup easily to allow for a number of different process effects.

BEE Process Flow Setups

Another powerful feature of our Emulsifying Cell is boundless customization. Along with the ability to control pressure, cavitation, impact, and shear, the process flow can also be controlled in any manner that you prefer.  This allows for guaranteed scale up from a laboratory setting to full blown manufacturing.

With a parallel flow setup, the product flows in one direction and exits from the opposite end of the nozzle of the emulsifying cell. In a reverse flow setup, the product is forced to flow back towards the nozzle, which creates an annular stream around the incoming jet stream, allowing for high shear. Finally, with a dual jet setup, two product inlets are used with two nozzles to create two jets of product, allowing for the most intense process.

We at BEE International pride ourselves on offering homogenizing equipment with the most customization on the market to allow for the best overall customer experience. To learn even more about our technology and line of homogenizers, please contact us today.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Colloid vs. Suspension: What is the Difference?

Posted by Tal Shechter on Jan 25, 2017 12:30:00 PM

colloid vs suspensionHomogenizers are gaining popularity in the industries of biotech, pharmaceutical, cosmetic, and food. They have been proven to simplify processes, improve taste, texture, and appearance of finished products, and save money – and time. Who wouldn’t want to implement this powerful technology? However, before selecting a homogenizer for the task at hand, it is important to understand two important by-products of homogenization – suspensions and emulsions. What are suspensions and emulsions? What are the differences? And how are they related to homogenization? Continue reading to learn the answers to these questions and more.

Suspensions

A suspension, simply put, is a mixture of two substances – one dispersed into the other. Examples of suspensions include droplets of oil in air, and sand in water. Particles in a suspension are easy to see, as they are larger than the particles making up the solution. Because of this quality, these larger particles within a suspension will settle if allowed to stand undisturbed. This inherent quality also makes suspensions very easy to separate through filtration.

Colloids

Colloids, like suspensions, can also be defined as a mixture of two components. The particles in a colloid can be solid, liquid, or gas; similarly, the medium that these particles are suspended in can also be solid, liquid, or gas. However, unlike suspensions, particles in a colloid are miniscule in size and cannot be easily separated or filtered. However, although the particles are small in size, they can be seen, thanks to the Tyndall effect, which is defined as the scattering of light by particles in a colloid.

BEE Homogenizers

With the knowledge of suspensions and colloids firmly under your belt, you can now wisely choose the right homogenizer for your application. No matter what the end goal, BEE International has the right homogenizer for the task. Our homogenizers are suitable for virtually any application and environment, including laboratory use, as well as pilot plant and industrial use. Our homogenizers offer the following benefits:

  • Guaranteed scale-up to production
  • Proprietary high pressure intensifier system
  • Compliant with CFR 21 part 11 requirements
  • Wide range of production capabilities and levels of automation
  • SCADA compliance
  • Sanitary design and features suitable for the pharmaceutical industry
  • Security modes and authorizations

To learn more about how our suite of high pressure homogenizers can help with your industry’s needs, please contact us today. For even more information, our eBook, “How to Achieve Efficient & Consistent Particle Size Reduction” can be downloaded for free here:

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Laboratory, Pilot, and Industrial Homogenizers: Which One is Right for You?

Posted by Tal Shechter on Jan 17, 2017 12:30:00 PM

laboratory pilot and industrial homogenizersIf you work in the cosmetic, pharmaceutical, biotech, or food industries, it is likely that you are familiar with the process of homogenization. Chances are even higher that you utilize this technique yourself. Homogenization, also known as micronization or particle size reduction, is a process that is growing increasingly popular in a number of industries. The simple act of reducing a particle’s size can have a far-reaching impact – among other benefits, homogenization can reduce overall costs, improve quality, increase a product’s shelf life, and improve overall customer satisfaction.  

However, before choosing the right homogenizer for your specific task, it is important to understand the options that are available. BEE International offers a number of homogenizers to suit the needs of virtually every industry. Our homogenizers are suitable for laboratory use, as well as pilot plant and industrial applications. Continue reading to learn more about the benefits our homogenizers can offer to your industry.

Laboratory Homogenizers

Laboratory homogenizers are smaller in size and are suitable for small scale applications in a laboratory or Research and Development setting.  At BEE International, our laboratory homogenizers offer unlimited options for creation emulsions and dispersions, as well as performing cell rupture or working with liposomes. Our laboratory homogenizers include the Nano DeBEE, Micro DeBEE, and Mini DeBEE models, which offer the following features:

  • High performance technology
  • Easy to use, clean and maintain
  • Repeatable and scalable results
  • Maximum operating pressure of 45,000 psi
  • Capacity of up to 22 L/hr

Pilot Plant and Industrial Homogenizers

For homogenizing larger volumes or scaling up results from the laboratory, BEE International’s line of Pilot Plant and Industrial Homogenizers are well-suited to meet your needs. Our pilot plant and industrial homogenizers include the DeBEE 2000, DeBEE 3000, and DeBEE 4000. These homogenizers utilize a patented emulsifying cell, which guarantees scalability of results. These homogenizers also offer the following benefits and features:

  • Reliable and predictable continuous operation
  • Patented intensifier technology that is reliable and versatile
  • Electronic synchronization that produces constant pressure
  • Unique Clean In Place (CIP) that allows for faster and more thorough cleaning
  • Menu guided maintenance and calibration
  • CE and cGMP compliant
  • Maximum pressure of up to 45,000 psi

To learn more about our line of high pressure homogenizers, please contact us today. Our free eBook, “How to Achieve Efficient and Consistent Particle Size Reduction,” is also available for download here:

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High Pressure Homogenization and Food Production: 3 Key Benefits

Posted by Tal Shechter on Jan 9, 2017 12:30:00 PM

homogenization food industryHomogenization, also known as micronization or particle size reduction, is heavily utilized in a number of industries, including (but not limited to): cosmetic, drug, pharmaceutical, biotech, and food. The process of homogenization offers many benefits to finished goods produced in virtually every industry. Continue reading to learn more about the benefits that high pressure homogenization offers as it relates to food production.

Pathogen Elimination

One of the notable benefits of high pressure homogenization is the elimination of harmful bacteria from food products. High pressure homogenization is becoming an increasingly popular way of eliminating pathogens from food without interfering with taste or quality.  The high pressure of homogenization, along with eliminating bacteria, also works to preserve the food.

Extension of Shelf Life

Another benefit of high pressure homogenization in the food industry is an extended shelf life of food products. The high pressure of homogenization results in improved chemical stability of foods, which allows them to stay fresh for longer, especially with foods comprised of small particles.

Improved Taste, Consistency, and Appearance

Perhaps one of the most important benefits, at least as it relates to consumers, has to do with the improved taste, consistency, and appearance of food that is processed using high pressure homogenization. Juice, milk, and other beverages have shown marked improvements in consistency and viscosity due to high pressure homogenization, which acts to suspend particles during processing.

BEE International offers a number of high quality high pressure homogenizers to meet the needs of virtually every industry. We offer homogenization equipment for laboratory use, pilot plant applications, and full scale industrial manufacturing.

Our homogenizers offer the following benefits and features:

  • CE and cGMP compliant
  • Pharma/Bio/Food sanitary
  • Synchronized pump system for constant pressure
  • Password operated protection
  • Menu guided maintenance and calibration
  • Patented emulsifying cell
  • Guaranteed scalability of results

To learn more about BEE International and how we can aid your homogenization process in the food industry, please contact us today. Our free eBook, “7 Key Factors to Consider When Choosing a Cell Lysis Method” can be downloaded here:

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What is Cell Disruption?

Posted by Tal Shechter on Dec 30, 2016 12:30:00 PM

what_is_cell_disruption.jpgCell disruption is the process of releasing molecules or other materials from inside a cell. The action of cell disruption is used in various industries, including pharmaceutical, biotech, cosmetic, food, and drug, and is commonly used by these industries to study intercellular materials or to use the materials that are located inside of a given cell.

Cell disruption can be either a preliminary step to homogenization — the act of micronizing or reducing particle size — , or it can take place simultaneously. In either case, cell disruption can occur via various methods. Continue reading to learn more about the methods for cell disruption.

Bead Method

In the bead method of cell disruption, the cells in question are disrupted via small glass, ceramic, or steel beads mixed with the sample that is suspended in media. In the bead method, the sample and bead mixture is manually agitated by either stirring or shaking.  This is a very common method that is popular in laboratory settings with small amounts of media, and is often used to disrupt yeast cells, as well as various types of animal and plant tissues.

Cryopulverization

The method of cryopulverization is often utilized when dealing with cells with a tougher outer membrane, such as animal connective tissues, cartilage, or seeds. In this method, the material in question is reduced to a very fine powder by impact pulverization at very low (liquid nitrogen) temperatures. Like the bead method mentioned above, cryopulverization is a very manual (and often slow) process.

Microfluidization

Microfluidization is a common method of cell disruption that is often used for proteins, enzymes, and cells, such as E. Coli. In this method, micro channels with fixed geometry are paired with an intensifier pump to achieve high shear rates that easily disrupt even the toughest of cells. While changes in viscosity are often noted with other methods of cell disruption, microfluidization avoids this phenomena, making it an attractive choice for cell disruption.

Nitrogen Decompression

Nitrogen decompression is the method of choice when dealing with more sensitive enzymes, organelles, and cells. In this particular method, large quantities of nitrogen are first dissolved in the cell under high pressure. As the gas pressure is released, the nitrogen escapes, which works to rupture and release the contents of the cell. This technique is used to homogenize cells and tissues, and produces an even dispersion of cells.

To learn more about cell disruption and how our line of high pressure homogenizers can help you achieve your goals, please contact us today.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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An Overview of Cell Homogenization Techniques

Posted by Tal Shechter on Dec 15, 2016 12:30:00 PM

cell-homogenization-techniques.jpgCell homogenization, also known as cell micronization or cell fractionation, is the action of reducing the particle size of molecules to facilitate even distribution and emulsification of liquids, creams, or other mediums. This process is extremely common, and is used in a number of growing industries: chemical, pharmaceutical, biotech, cosmetic, and food.

In the world of cell homogenization, there are several techniques that are commonly used to achieve this task. All of the methods involve encouraging the cells to lyse, or break apart. Cell homogenization can be achieved through various methods, including mechanical disruption, liquid homogenization, sonication, or manual grinding. Continue reading for a brief overview of each method of cell homogenization.

Mechanical Disruption

Mechanical disruption involves the use of rotating blades. These blades work to grind and disperse cells, and are most effective at homogenizing tissues such as liver.  Rotor-stator homogenizers are one of the best homogenizing tools used in mechanical disruption, and can homogenize samples in the volumes from 0.01 milliliters to up to 20 liters, depending on the type of motor that is used. Sample loss is typically minimal, and small amounts of samples and tissues can easily be homogenized using this method.

Liquid Homogenization

Liquid homogenization is the most widely used cell disruption technique, especially with small volumes and cultured cells. In this method, cells are lysed by the action of being forced through a small space, which acts to shear the cell membranes. There are several types of liquid homogenizers on the market, including Potter-Elvehjem homogenizers, french presses, and the dounce homogenizer.

Sonication

Sonication is a type of physical disruption used to lyse cells. This method uses high frequency sound waves to lyse cells, bacteria, and other types of tissue. The sound waves are delivered via a probe that is immersed in the liquid cell suspension. This method, while common, is often time consuming and is best suited for volumes of less than 100 mL.

Manual Grinding

Manual grinding, while one of the most time consuming methods of cell homogenization, is also the most common. In this method, a mortar and pestle is used to manually grind cells. While not suitable for extremely large volumes, this method is the most effective at breaking apart plant tissue cells.

BEE International offers a wide variety of high pressure homogenizers to meet the needs of virtually any industry. Our technology is well suited for nano emulsions, cell lysis, uniform particle reduction, and other related applications.

Contact us today to learn more about how our line of homogenizers can help with your company’s needs. For more information on cell lysis methods and how to choose the right one, download our FREE eBook:

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