Comparing the 3 Most Common Homogenizers: Ultrasonic, Bead Mill and High Pressure Homogenizers

Posted by Tal Shechter on Oct 12, 2016 12:30:00 PM

Ultrasonic_Bead_Mill_and_High_Pressure_aUltrasonic_Bead_Mill_and_High_Pressure_aultrasonic-bead-mill-high-pressure.jpgBEE International knows that choosing the right homogenizer can be a tricky business. You need to find the right size, right mechanism, right force and more for your specific application. Because of our extensive experience in the industry, we are here to help you make this tough decision.

Below, we have compared the characteristics of three of the most common types of homogenizers – Ultrasonic, Bead Mill, and High Pressure Homogenizers.





Type of Homogenizer


Bead Mill

High Pressure


of action

Pulsed, high frequency sound waves are used for particle size reduction and cell lysis. Ultrasonic energy is transmitted directly from the probe into the sample, or indirectly through a water bath.

The sample is fed into a chamber surrounded by beads in a closed system. The beads are rapidly agitated to grind and homogenize the sample, breaking up tissue and disrupting cells.

Liquid is driven at ultra high pressure through a small nozzle. The liquid becomes a high velocity jet stream and flows through an absorption cell, which contains alternating small and large orifices.


Cavitation, Shear


Cavitation, Turbulence, Fluid-on-Fluid Impact, Shear

Sample Type


Liquid or Solid



Great for small, liquid samples that require thorough homogenization.

Good for breaking up tissue. Quick and high-throughput. Samples are self-contained, therefore reduced opportunity for cross contamination.

Constant, uninterrupted processing pressure eliminates the possibility of contamination. Capable of producing very small, sub-micron particle sizes.

Consistent, great results in fewer passes.


Unsuitable for applications where the sample is mostly solid and / or not immersed in a liquid buffer.

Ultrasonic homogenizers can shear DNA, which could be undesirable. Generate heat and noise. Possibility of cross contamination.

Sample size limitations. Due to the nature of the mechanism of action, it is impractical to design bead mill homogenizers for large volumes.

High-pressure homogenizers tend to be large and extremely heavy. Expensive.  



Processing liquid samples in laboratories.

Processing solid tissue samples in laboratories.

Processing milk, beverages, drugs, cosmetics and more in laboratories, pilot plants and large-scale production.


BEE International high pressure homogenizing systems produce consistent and 100% scalable results. You can be sure that these results are reproducible through pilot and clinical trial settings, and up to manufacturing. We are committed to the success of your product, and will be the first to tell you if our technology or equipment is not the right fit.

Visit our website or contact us to learn more about our products and technology. For more information on homogenizers and factors to consider when choosing a cell lysis method, download our FREE eBook:

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