Our Rainbow real-time dynamic dissolution monitor was recently used in a study to determine in vitro dissolution rates, described in a paper entitled, The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character.
The paper explores the interplay between particle size reduction via micronization and nanoization and the solubility and dissolution of drug compounds. One of the key conclusions was, "It was demonstrated that micronization does not change the equilibrium solubility of a drug, but it results in a faster dissolution."
Our Rainbow in situ UV-vis fiber optic, probe-based system combined with our BEE high pressure homogenizers for particle size reduction/micronization can help scientists in early drug formulation development explore size vs. dissolution relationships in vitro using biorelevant media to mimic physiological conditions.
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