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BEE International Blog

How High Pressure Homogenizers Benefit the Food Industry

Posted by David Shechter on Feb 8, 2016 12:30:00 PM

<a href="http://www.shutterstock.com/gallery-1464035p1.html?cr=00&pl=edit-00">Tooykrub</a> / <a href="http://www.shutterstock.com/editorial?cr=00&pl=edit-00">Shutterstock.com</a>Across the past decade, sales of both packaged and fresh foods have jumped impressively and look to continue growing. Even with this expansion, however, food companies are becoming increasingly aware of their food’s impact on the obesity epidemic and its overall quality compared with other products on the market. (1) The size of the particles that comprise a food product has a huge impact on both of these factors, with the goal of smaller rather than larger particle sizes. Although multiple mixing methods exist, homogenization is able to achieve impressively small particle sizes compared with competitors. Below is a compilation of uses for homogenizers, specifically particle size reduction from homogenization, can be useful for products in the food industry.

Improves Health Status

Although not a well-studied area compared with other nutritional sciences, particle size reduction from homogenization confers significant health benefits. These criteria will make a food product more marketable to the consumer.

  • Increases Growth

One of the more notable studies on the subject studied juvenile Nile tilapia fish. The fish were given food pellets of varying particle sizes and analyzed for growth. Interestingly, hose feeding on the food pellets comprised of small particles grew significantly more than their large-particle-pellet counterparts. (2)

  • Reduces Food Intake & Boosts Satiety

Reduction in food intake typically confers weight loss and improved health status. In a study that analyzed the link between particle size and food intake, a study group of men were given either a drink composed of 2 µm particles or 50 µm particles. Those who drank the 2 µm particle-drink ate up to 12% less than their counterparts at a buffet-style lunch later in the day. Additionally, this study inferred a critical link to satiety, in that those who ate less were satiated sooner. (3)

Stabilizes Products

Chemical stability is key to determining a food’s shelf life and taste. High pressure homogenization uses pressure instead of heat to achieve a product; this translates to preservation of quality, taste, and nutritional, whereas heat would have a negative impact on these factors. By using pressure to break down particles, the resulting food has a more stable structure and overall higher quality. Interestingly, the food’s texture is also enhanced by particle size reduction, which can create a better experience for the consumer. (4)

BEEI: High Quality Particle Size Reduction Equipment

A food’s ability to have its intended effect can be attributed to a wide variety of factors. In particular, particle size and consistency in size are high-impact factors that every food manufacturer should consider. The first step in synthesizing a food product that confers high bioavailability is purchasing equipment that will achieve consistent particle size distribution. One such example is the high pressure homogenizer by BEE International Technology. Their products are trusted by researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions; importantly, this equipment can achieve consistent particle sizes at or below 100 nm, a key benefit for any product coming from the food industry. 

Learn more about how BEEI can aid your particle size reduction process by looking at our high pressure homogenizers or if you're interested in how our homogenizers can help you achieve efficient and consistent particle size reduction, download our FREE eBook now:

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Topics: Foods, Homogenization

Why BEE High Pressure Homogenizers Yield Better Results Than High Shear Mixers

Posted by Deb Shechter on Feb 5, 2016 12:30:00 PM

why-bee-high-pressure-homogenizers-yield-better-results-than-high-shear-mixers.jpgHomogenization has been in existence since the early 1900’s, when the food industry began producing homogenized milk. As the years progressed, homogenizer technology evolved to the high-functioning machines we are now familiar with. Aside from homogenizers, high shear mixers and other less commonly used equipment also have a space in the science industry. So when you have a product that requires powerful mixing, how will you decide whether a high pressure homogenizer or a high shear mixer is your best option? Keep reading to understand high pressure homogenizers from BEE International (BEEI) are your best bet for both type of equipment and company.

Contains a Proprietary Emulsifying Cell

BEEI’s homogenizers contain a proprietary Emulsifying Cell, which has significant benefits for processes that involve cell lysis and/or particle size reduction. Specifically, its design replicates passing through the cell multiple times in just 1-2 passes. This ability is due to reactors that induce absorption, which creates a new blend of products and/or extends the process duration. Additionally, the Emulsifying Cell has multiple locations that can be adjusted, which allows scientists across industries to optimize their processes. And finally, the Emulsifying Cell has impressively high shear compared with other high shear mixers. Impacted by both velocity and length, this higher shear allows for significantly further reduced particles. As such, the BEEI Emulsifying Cell should be the go-to equipment for any homogenizer needs.

Higher Amount of Energy Imparted

The central difference between high pressure homogenizers and high shear mixers, in addition to other such equipment, is the amount of energy transmitted on a product. This can be measured indirectly via pressure and particle size, as smaller particle sizes require higher pressure and therefore larger amounts of energy imparted into the the product. BEEI homogenizers have a maximum operating pressure of 3100 bar, which allows them to achieve impressively tight distributions of small particles in only 1-2 passes.

Equipment Flexibility to Meet Diverse Needs

BEEI’s high pressure homogenizer offers the user the autonomy to alter multiple factors, so as to accommodate various industries and products. For example, the maximum process intensity is 45,000 psi, yet you may be working with a product that requires low intensity for a long period of time. Lowering the process intensity to your specifications is as simple as the turn of a dial. As noted above, BEEI homogenizers can also achieve an impressively high operating pressure, which can also be easily adjusted. In addition, other mechanical forces with central roles in process effectiveness are built into the homogenizers and are easily alterable; these include cavitation, shear, and turbulence. In contrast, most high shear mixers do not have the option of adjusting many of these components. In fact, may homogenizers also don’t offer these options, which should impart the importance of selecting BEEI over other brands and mixers.

BEE: The Homogenizer Advantage

As you work to determine whether a high pressure homogenizer or high shear mixer will be better suited for your laboratory, begin your search with BEE International Technology. We are globally recognized among laboratory managers and researchers for our high quality products and excellent customer support. Cell lysis and particle size reduction are two of a variety of applications for BEEI homogenizers; nano/micro emulsions, lipids, suspensions, and dispersions are also easily achievable. Additionally, the homogenizer processes can be controlled to suit your product, which will allow you to customize to your cell type. And finally, the equipment is easy to use, produces higher yield in less time, and achieves results that are reproducible and scalable.

Learn more about how BEE homogenizers can improve your experimentation by visiting our high pressure homogenizer products. Or if you're interested in seeing how our homogenizers can help you achieve efficient & consistent particle size reduction, download our FREE eBook:

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Topics: Homogenizer

Why Is Size Reduction An Important Step In Pharmaceutical Formulations?

Posted by David Shechter on Feb 3, 2016 12:30:00 PM

why-is-size-reduction-an-important-step-in-pharmaceutical-formulations.jpgI’ve always thought of the pharmaceutical industry as an all-or-nothing kind of business. Either you hit the jackpot with a highly effective and marketable product or you see a flop. Successful pharmaceutical formulations require significant R&D and proven success. Strongly correlated to the likelihood of success is the size of the particles that comprise the product itself. Keep reading to better understand the importance of particle size reduction in pharmaceutical formulations.

Eases Swallowing

Of the multiple drug delivery methods, oral delivery is the most common. Ease in swallowing is therefore an important consideration when working on an oral tablet’s formulation. By implementing a tablet coating that is comprised of smaller particles, grittiness is decreased and swallowing ability is enhanced.

Improves Bioavailability

Oral drugs that are highly soluble and permeable also confer increased bioavailability. However, the direct correlation between solubility and bioavailability is a bad omen for poorly soluble drugs. Interestingly, decreasing a product’s particle size increases its surface area, which raises the surface area to volume ratio. Particle size reduction technology is therefore an effective method of increasing bioavailability of poorly soluble drugs, without altering its chemical formulation. As an added bonus, improved bioavailability is cost-effective for the manufacturer. Since less product needs to be produced to achieve the same effect, a portion of manufacturing costs can be negated. (1)

Increases Stability

Product stabilization is important to consider as you work on its formula. Stable products are protected against colloid aggregation and phase separation, which decreases both physical appearance and overall effectiveness. Additionally, product stability is correlated with bioavailability. By achieving both a consistent and small particle size distribution, a product will be more stable and ultimately more effective. (2)

BEE High Pressure Homogenizer Advantages

As you hunt for particle size reduction equipment that will suit your pharmaceutical purposes, consider how the above-listed factors will improve the quality of your products. Although many companies manufacture homogenizers, few are of the high quality needed to achieve reliable and reproducible results. One example of equipment that does meet such expectations is the high pressure homogenizer by BEE International Technology.

BEE’s products are trusted by researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions; importantly, this equipment can achieve consistent particle sizes at or below 100 nm, a key benefit for researchers & corporations across a wide variety of industries.

Learn more about BEE’s particle size reduction equipment or download our FREE eBook "Advantages of BEE Homogenizers for the Pharmaceutical Industry" to read more about how BEE International's technology can benefit your pharmaceutical applications:

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Topics: Pharmaceutical

How to Reduce Cost of Manufacturing with High Pressure Homogenizers

Posted by Deb Shechter on Feb 2, 2016 12:30:00 PM

how-to-reduce-cost-of-manufacturing-with-high-pressure-homogenizers.jpgThe manufacture of any product is an expensive endeavor that has caused numerous corporations to see red in the budget books. Purchasing expensive equipment may therefore be low on the to-do list, particularly as you prioritize other aspects of the process. For example, high pressure homogenizers are expensive pieces of equipment. Yet they can produce numerous products and may save you money in the long run if you plan smartly. Keep reading to learn how you can reduce the cost of manufacturing to support purchase and use of a high pressure homogenizer. 

Document Material Usage

For your company to see a profit, you must have both understanding and written documentation of the amount of raw materials used to achieve your product of interest. Specifically with large-scale homogenization, material needs are variable and subject to high costs, considering the quantity needed for manufacturing. In this case, taking account for potential overages within the budget will help avoid unnecessary and costly spending. Additionally, each raw material should be priced out. Having an understanding of legitimate corporations you will be able to purchase from, as well as where to turn for specialty raw materials, may significantly ease the mental and financial burden.

Expand Your Equipment Usage

Classically linked with the dairy/beverage industry, modern homogenizers are associated with products across industries, such as food, pharmaceutical drugs, latex polymerization, and chemicals. Because homogenization can be accomplished with fats, water, flavorings, and solids, the equipment can be used for multiple processes that might otherwise confer numerous pieces of equipment. (1)

Plan For Utilities Costs

Although easily overlooked, utilities costs can quickly become burdensome in a manufacturing facility. Industrial homogenizers need to process significant amounts of product, which also requires significant amounts of energy.However, these costs can be decreased with some smart planning and research. Because coal and natural gas costs may vary by location, it will be smart to research how costly they may be at your facility. Plenty of proven methods of estimating and writing utility usage into a budget exist, and you will simply want to find the one that works best for you and your purposes. 

BEE International: Cost Effective Homogenizers

Ultimately, regardless of the above factors, it will be much easier for your laboratory to save money if you start with high-quality equipment. Not only will this ensure optimal product results, but it will also decrease the maintenance requirements. High pressure homogenization is the most common method for particle size reduction because of both its powerful mixing process and its cost/time effectiveness. The homogenizer will shear fluid by forcing it through a restrictive valve, forming a product with decreased particle size. 

BEE International is trusted by researchers around the world. We deliver an array of key benefits, such as production of nano/micro emulsions and dispersions and lipids and suspensions; these can be used in a variety of ways within the food & beverage, pharmaceutical, chemical, and biotechnology industries.

Learn more about how BEEI homogenizers can assist your dual goal of high quality product and cost effectiveness or read more about how to perfect your particle size reduction process in our FREE eBook:

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Topics: Homogenization

What’s the Difference Between Emulsions and Dispersions?

Posted by David Shechter on Jan 29, 2016 12:30:00 PM

whats-the-difference-between-emulsions-and-dispersions.jpgMany of the products that assist us with our daily lives- from milk, dyes, ink, sunscreen, and pharmaceutical creams- are comprised of emulsions or dispersions. These two products, while foreign to non-science general public, are very familiar to the researchers and scientists utilizing them. However, emulsions and dispersions are incredibly similar, and it is therefore easy to misinterpret them as the same. Below is a characterization of emulsions and dispersions, and how each is distinct from the other.

Characterization

An emulsion is a uniform mixture of two immiscible liquids, most commonly oil and water. Oil-in-water (o/w) emulsions with a continuous water phase are characterized by products such as moisturizers. In contrast, the other major type, water-in-oil (w/o) emulsions, have a continuous oil phase and are known for products like sunscreen. Other commonly known products with an emulsion base include greases, milk, vinaigrette, and latex polymerization.

A dispersion, on the other hand, is a solution comprised of small solid particles dispersed in a second phase, most commonly water, Because the solid particles are water insoluble, they must undergo powerful mixing with water to create a uniform and homogenous mixture. Common examples of dispersions include ketchup, antacid, ink, dye.

Formation

Because both emulsions and dispersions are comprised of liquids or solids that would not normally mix, they require a strong mixing process and stabilizers/surfactants to maintain the homogenous state. Emulsion preparation requires three ingredients: oil, water, and a surfactant. Macroemulsions is relatively easy, and can be accomplished with a high-speed stirrer. If you desire smaller droplets, as are found in microemulsions, higher levels of surfactant and energy are required; homogenization can achieve the smaller droplets fairly easily. (1) Dispersion formation is characterized by four major steps: 1) Wetting to displace air from the particles, 2) Physical separation, accomplished using shear to apply mechanical energy, 3) Stabilization to prevent particle re-adhesion, and 4) Processing through homogenization.

BEE International: Emulsions/Dispersion Production Equipment

As you either embark on, or continue along, the process of producing emulsions or dispersions, your product’s success may depend on the equipment used to make it. High pressure homogenization is a common method for synthesizing both products, because of both its powerful mixing process and its cost/time effectiveness. The homogenizer will shear fluid by forcing it through a restrictive valve, forming a high-quality emulsion.

BEE International Technology is trusted by lab managers and scientists around the world for their high-pressure homogenizers. They offer homogenizers that are both high-quality and reliable, and which can help your lab produce nano/micro emulsions, dispersions, and suspensions..

Visit our high pressure homogenizer products to learn more about how we can improve your product production process. If you're interested in producing better emulsions & dispersions, you'll need to achieve smaller droplets which requires efficient and consistent particle size reduction. Download our FREE eBook now to learn how to achieve this:

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Topics: particle size reduction, microemulsions

How Custom Homogenizer Options Can Optimize Cell Lysis

Posted by David Shechter on Jan 27, 2016 11:30:00 AM

how-custom-homogenizer-options-can-optimize-cell-lysis.jpgBreaking down a cell’s protective membrane exposes precious intracellular contents. These proteins, organelles, and other such molecules provide researchers with a wealth of information about how the organism functions in both healthy and disease states. The process of cell rupture, most commonly accomplished through homogenization, requires optimization for high product yield. Although many homogenizer brands exist on the market, only some allow their users the autonomy of customization. Keep reading to learn about how custom homogenizer options can help you optimize your cell lysis technique.

Many Cell Types Can Be Accommodated

The difference in lysis process between cell types stems largely from whether or not there is a cell wall present. Bacterial, yeast/fungal, and plant cells have a tough cell wall that requires significant force to disrupt. In contrast, only a membrane separates mammalian intracellular contents from the extracellular environment. Mammalian cells thus require a more gentle method of disruption. Homogenizers that provide customization, such as in pressure and intensity, allow the user to adjust these factors for the cell type being used. If today you were lysing a human fetal cell and tomorrow an onion root tip cell, a customizable homogenizer would allow you to maximize product yield in both.

Scalable to Larger Sample Sizes

You are probably all-too-familiar with the high costs associated with science, particularly in the research and development stage of product development. Scalability ensures that you can invest in a project with full confidence that it won’t outgrow its original system, measured in terms of both cost and time efficiency. Custom homogenizer options allow the user to optimize a technique and then progress to a larger sample size while continually optimizing and attaining high product yield.

Unique Applications Can Be Achieved

Regardless of the intended application for your cell lysis product, a customizable homogenizer will be able to accommodate it. This allows for a much more diverse equipment functionality, which will probably help you feel that the money you spent on that pricey homogenizer was well-directed. Some examples of adjustable forces include shear, cavitation, process intensity, and turbulence. (1)

BEE International: Quality Cell Lysis Equipment

Use of flexible cell lysis equipment will provide numerous benefits for both production laboratories and consumers alike. And there are plenty of companies on the market to select your equipment from. However, the lysate can be of higher quality and more even consistency when run through top-shelf equipment, most frequently in the form of a homogenizer. BEE International Technologies is trusted by researchers around the world for both their laboratory homogenizers and their associated customer support. Cell lysis is just one of a variety of applications for BEEI homogenizers; nano/micro emulsions, lipids, suspensions, and dispersions are also easily achievable. Additionally, the homogenizer processes can be controlled to suit your product, which will allow you to customize to your cell type. And finally, the equipment is easy to use, produces higher yield in less time, and achieves results that are reproducible and scalable.

Learn about how to make your cell lysis protocol more effective by checking out our laboratory homogenizers! Or if you're looking for more information on how to optimize your cell lysis method, download our FREE eBook "7 Key Factors to Consider When Choosing A Cell Lysis Method" now:

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Topics: cell lysis, Homogenizer

Advantages of High Pressure Homogenization For Biotechnology

Posted by David Shechter on Jan 26, 2016 11:30:00 AM

advantages-of-high-pressure-homogenization-for-biotechnology.jpgThe biotechnology industry is booming with the increasing demand for alternative biofuels, modified vaccinations, and effective medicine with fewer side effects. Synthesis of most such products requires a mixing method that can achieve both particle size reduction and cell lysis. The preferred mixing method is homogenization, specifically high pressure homogenization, in its significant advantages over other existing mixing methods. Read below to learn more about the advantages of using high pressure homogenization for biotechnology research.

Equipment Flexibility to Meet Diverse Needs

Gaining access to intracellular contents requires penetration of the protective cell barrier. For cells such as bacteria, plant, and yeast/fungal cells, a tough cell wall must be penetrated; yet mammalian cells require less force to disrupt the cell membrane while leaving intracellular contents intact. Quality high pressure homogenizers typically offer the user autonomy to alter the pressure, so as to accommodate multiple cell types. In addition to high pressure, multiple mechanical forces act on the product; these include process intensity, cavitation, shear, and turbulence. Each can be easily adjusted to meet the diverse needs of biotechnology researchers. 

High Protein Recovery

Many of the products coming out of the biotech industry require access to intracellular proteins. As noted above, high pressure homogenizers are customizable to help optimize the process. Just as important, however, is the product yield from that process. Hot mixing methods oftentimes cause product degradation, which adds up over a long period to confer increased spending and time spent. A key benefit of high pressure homogenizers is the use of pressure instead of heat, which allows for higher protein recovery. 

Scalability

Particularly applicable for researchers in the biotechnology industry, scalable equipment can adapt to increased demand and/or sample size. Because most biotech products are destined for manufacturing, they will eventually need to be successful in a large-scale machine. Before progressing with a technique, it is essential to have a clear understanding of its purpose and goal result. A company that manufactures homogenizers for both laboratory and industrial use will be the safest bet. A technique that was optimized with a laboratory homogenizer will then easily translate to a larger-scale program. 

BEE International: High Pressure Homogenizer Advantages

The search for particle size reduction equipment should begin with a consideration of how the above-listed factors will improve the quality of your products. Although many companies manufacture homogenizers, few are of the high quality needed to achieve reliable and reproducible results. Importantly, even fewer are customizable to a product’s specific needs. One example of equipment that does meet such expectations is the high pressure homogenizer by BEE International Technology. 

BEE’s products are trusted by researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions; importantly, this equipment can lyse a variety of cell types while preserving crucial intracellular contents through customizable machinery. Additionally, it can achieve consistent particle sizes at or below 100 nm, a crucial factor for researchers & corporations in the biotechnology industry.

Learn more about how BEEI can improve your biotechnology research with our biotech high pressure homogenizers. Or if you're interested in a specific application, such as cell lysis, download our FREE eBook "7 Key Factors to Consider When Choosing A Cell Lysis Method" now:

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Topics: Biotechnology, Homogenization

3 Benefits of High Pressure Homogenization for Nanoparticles

Posted by Deb Shechter on Jan 25, 2016 12:30:00 PM

3-benefits-of-high-pressure-homogenization-for-nanoparticles.jpgNanoparticle research is widespread and of high interest to the scientific community. With uses such as gene delivery, protein detection, tissue engineering, drug delivery systems, and fluorescent biological labels, it is no wonder that scientists continue to probe further. (1) Nanoparticle preparation can be accomplished via multiple methods, yet high pressure homogenization is the most common, and with good reason. Keep reading to learn about the benefits of high pressure homogenization for nanoparticle synthesis.

  • Customizable Forces to Optimize Results

Unlike other mixing equipment, high pressure homogenizers combine both pressure and mechanical forces to achieve a uniform and consistent product. Mechanical forces can include turbulence, shear, cavitation, impact, and process intensity. High quality homogenizers offer the option to easily adjust these forces, which allows the researcher to optimize product results. This factor is key to achieving a functional nanoparticle, as well as for any other product made via high pressure homogenization.

  • Hot & Cold Homogenization Options

High pressure homogenization can be accomplished using either hot or cold temperatures. Hot homogenization uses heat above the lipid melting point to to obtain an aqueous phase. However, hot homogenization has significant drawbacks, particularly in the drug delivery arena; these include heightened product degradation, drug loss from the aqueous phase, and uncertain lipid transitions. In contrast, cold homogenization was developed to overcome the drawbacks of hot homogenization and is conducted with solid lipids. Because each method is preferable for different circumstances, having the option to select one or the other allows researchers to achieve optimal product results. (2)

  • Smaller Particle Sizes Than Other Equipment

Because of the significant amount of pressure imparted on the product, alongside the actions of mechanical forces, high pressure homogenizers are unique from other mixing equipment. These forces allow for synthesis of smaller particle sizes, which confers increased nanoparticle surface area and bioavailability. Particularly for drug delivery systems and other pharmaceutical purposes, these factors are key to an effective treatment.

BEE International: Homogenizers for Nanoparticle Production

Production of nanoparticles involves high-pressure emulsification, typically through homogenization. Homogenization is the preferable method due to its ability to reduce particle sizes more significantly than other blending/emulsification methods. (2) The first step in synthesizing a high quality nanoparticle is purchasing equipment that will achieve small and consistent particle size distribution. One such example is the high pressure homogenizer by BEE International Technology. Our products are trusted by pharmaceutical researchers and lab managers around the world for key benefits, such as production of nano/micro emulsions, dispersions, and suspensions; importantly, this equipment can achieve consistent particle sizes at or below 100 nm, a key benefit for researchers & corporations that synthesize pharmaceutical products.

In addition, BEEI has extensive experience assisting its product users as they transition through the drug development process. Our homogenizers are differentiated for R&D, clinical trials, and manufacturing, and our customer support is reliable, experience-driven, and effective.

Learn more by checking out our particle size reduction equipment or downloading our FREE eBook "How to Achieve Efficient & Consistent Particle Size Reduction": 

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Topics: Homogenization

Why Scalability Matters In Selecting A Pharmaceutical Homogenizer

Posted by Jen Hug on Jan 21, 2016 12:30:00 PM

why-scalability-matters-in-selecting-a-pharmaceutical-homogenizer.jpgThe drug development industry is one of trial and turmoil. Only about 12.5% of products that enter clinical trials will make it to manufacturing, and an even smaller fraction will successfully move from R&D to clinical trials. (1) It truly is a shame to think that many of the products which consumers will never see held the potential for successful drug therapy. One way to ensure your pharmaceutical product does not meet this fate is by scaling homogenizer equipment, which is frequently used along the drug development process. Keep reading to improve your understanding of why scalability is important when selecting a homogenizer.

Increased Cost Savings

You may be reading this from one of many perspectives: that of an independent lab researcher, in-house, or contracted by a large corporation. No matter the category you fall under, you are probably all-too-familiar with the fact that conducting research is incredibly expensive, particularly in the drug development industry. Particle size reduction via homogenization is frequently used in the pharmaceutical industry. The ability of this method to be scaled ensures that you can invest in a project with the confidence that it will still work on the larger machinery. Alternatively, if the method could not be scaled, significant monetary funds would be required to order more reagents and begin again at the small-scale level.

Lower Time Requirement

By developing a scalable particle size reduction technique from day 1, significant amounts of time can be saved. Importantly, it is not just the technique itself that needs to be optimized; it is the equipment the technique is being used on that may determine its success. By using a particle size reduction on scalable equipment starting at R&D, the same technique should easily work on a pilot-plant homogenizer in clinical trials. No researcher wants to get stuck with an optimized R&D technique that doesn’t work when their product moves to clinical trials or manufacturing.

Overall Decreased Likelihood of Failure

As mentioned above, scalable equipment should be used from the start of R&D all the way through the manufacturing stage. Failure to do so will cost both time and money, as any technique that didn’t scale will have to be re-optimized on the lab bench. Importantly, if the equipment you have access to can support a scaled process, your chances of making it to the golden manufacturing stage are higher.

A number of homogenizer manufacturers have different models available for each phase of drug development; for example, BEE International is renowned for their homogenization equipment and ability to help a customer through the drug development process. They offer laboratory homogenizers for R&D, pilot scale homogenizers for clinical trials, and industrial homogenizers for the manufacturing phase. The scalability of these homogenizers- e.g., a method that was successful with the laboratory homogenizer will also be successful with the industrial homogenizer- is a huge benefit that can save both time and cost.

Although this writing focused centrally on the pharmaceutical industry, homogenizers are frequently used in the chemical, biotechnology, and food & beverage industries as well. BEE delivers an array of key benefits to each industry, such as production of nano/micro emulsions, dispersions, lipids, and suspensions. When selecting a company that offers scalable particle size reduction equipment, begin with BEE; not only do they manufacture the highest quality equipment, but they also offer customization and proprietary software to help optimize processes.

Learn more about how BEEI can help you scale your process with our high pressure homogenizers. Or if you're interested in reading more about how BEE's homogenizers benefits pharmaceutical applications, download our FREE eBook now:

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Topics: Pharmaceutical

What To Look For In A Homogenizer Manufacturer

Posted by Deb Shechter on Jan 20, 2016 12:30:00 PM

what-to-look-for-in-a-homogenizer-manufacturer.jpgHomogenization is a necessary method for researchers across industries. From developing pharmaceutical drugs to accessing precious intracellular contents, the equipment used can be very telling about the quality of a product. However, you will find that there are numerous homogenizers and manufacturers to select from. Read further to better understand the unique benefits you should be looking for in a homogenizer and its manufacturer.

  • Particle Size Reduction

Most high-pressure homogenizers function to reduce particle size, yet few can achieve the small sizes for optimal product function. Some machines, such as those manufactured by BEE International, can achieve 0.1 μm particle sizes, whereas conventional high-pressure homogenizers achieve maximum reductions of 0.5 μm and conventional high shear mixers achieve reductions of 5 μm on average. BEEI’s impressive particle sizes can also be achieved in fewer passes; in some cases, 90% of sample is reduced to target size in just one pass, which improves overall efficiency and product quality. 

  • Lysing Capability

Regarding homogenization, one of the central uncertainties among scientists is the type of cell that can be lysed. While BEEI high-pressure homogenizers most commonly lyse E. coli and yeast, there are certainly other cell types that have been lysed with the equipment. Regardless of the cell type you want to use, always test it first to ensure that you are achieving the intended result.

  • Mechanical Forces

Multiple mechanical forces can be incorporated into a homogenizer, and should be available with the homogenizer you select. These forces allow the user to optimize a product’s quality by lengthening shelf life, improving sensorial properties, and improving biophysical properties. Commonly included are turbulence, cavitation, high shear rates, impact, and adjustable process intensity.

  • Quality

High-pressure homogenizers should contain a wide array of capabilities that allow the user to customize his/her experiment. Although these are infrequent among many homogenizer brands, such capabilities are critical to optimizing the method for distinct products. For example, a customizable homogenizer would allow users to manually set their homogenizer to parallel or reverse flow or run samples as many times as needed to achieve 100% particle reduction to target size. 

  • Support & Warranty

On the quest to purchase equipment that is both critical to your drug’s production and costly to repair, it is important to know that support and warranty details are helpful and customer-centered. For example, BEEI’s training and installation process help customers feel comfortable with both the equipment and the process; they also provide application-related support via phone as needed. Prior experience has informed BEEI support representatives, who can guide customers through issues or processes via telephone or even Skype.

You can begin your search for homogenizers by comparing the laboratory homogenizers from BEE International Technology. Our products are trusted by pharmaceutical researchers and lab managers around the world for delivering an array of key benefits; these include production of nano/micro emulsions, dispersions, lipids, and suspensions. In addition, we have extensive experience in the challenges that our pharmaceutical customers face as they transition from concept, through to R&D, clinical trials, all-important FDA approval and finally, to manufacturing.

Learn more about our high pressure homogenizers by looking over our product pages! Or if you're interested in learning more about how our homogenizers can benefit your pharmaceutical products, download our FREE eBook now:

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Topics: Homogenization

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