Producing Effective Dispersions

Posted by Deb Shechter on Jul 18, 2017 11:00:00 AM

Producing Effective DispersionsProducing effective dispersions is a challenge that many industries – including pharmaceutical, biotech, and cosmetic – face on a continuous basis. In the growing world of dispersions, cell lysis,  micronization of particles, and other applications requiring the use of a homogenizer, bridging the gap between R&D and manufacturing is a costly and often unsuccessful challenge.

BEE International has extensive experience in the field of development and production of homogenization equipment, suitable for virtually any application, beginning from the early stages of planning, research and development work, and scale up, all the way to final implementation and production.

When it comes to producing dispersions, it is a task that requires much preparation, foresight, and planning, but with proper preparation, knowledge, and tools, it is a satisfying and profitable endeavor.

Replicating dispersion in a large-scale production environment that has been successfully implemented in a smaller laboratory setting can be difficult. Even when a satisfactory particle size has been achieved, when produced on a larger scale, it may not have the same qualities and characteristics as what was created in the laboratory setting. Inconsistencies can be observed in many areas, including (but not limited to):

  • Differing size and/or densities of media
  • Differing throughput rates of media
  • Mill wear and changes in millbase viscosity
  • Dispersion at differing speed/rate/power

The process of dispersion requires a high level of attention to detail, accurate input variables, and consistent design criteria. BEE International offers high quality laboratory systems that address and standardize all of the numerous factors that can affect a scaled up dispersion process. Our homogenizers, including the Nano DeBEE 45-2, Micro DeBEE 45, and Mini DeBEE 30, are built for reliability and repeatability, and are able to keep up with the high pace of a full-scale 24/7 manufacturing environment.  

Our pilot plant homogenizers, designed for scaling up homogenization, micronization, and dispersion from the R&D stage all the way to full-blown production, can be customized to fit your schedule, production needs, and budget.  Our homogenizers include key features for successful  scaling of dispersions, including:

  • Low-High operating pressure from 5,000-45,000psi
  • PLC panel to control process pressure, temperature, and other parameters
  • Constant process pressure
  • Custom process configurations to enable control of shear and impact
  • Adjustable back pressure
  • Heat exchangers for cooling of product
  • Guaranteed scale up from R&D to manufacturing

BEE International’s DeBEE 2000, our pilot scale high pressure homogenizer, contains a 10 horsepower motor which converts hydraulic power through high pressure cylinders. The unit is capable of reaching up to 45,000psi and is suitable for the scale up needs of most major manufacturing industries.

Contact us for more information on our pilot plant homogenizers and other equipment to meet your dispersion scale up needs. 

For more information on key factors to consider when choosing a cell lysis method, check out our FREE eBook today: 

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4 Techniques in Cell Homogenization

Posted by David Shechter on Jul 6, 2017 11:30:00 AM

Cell HomogenizationCell homogenization, also known as cell micronization or cell fractionation, is the action of reducing the particle size of molecules to facilitate even distribution and emulsification of liquids, creams, or other mediums. This process is extremely common and is used in a number of growing industries: chemical, pharmaceutical, biotech, cosmetic, and food.

In the world of cell homogenization, there are several techniques that are commonly used to achieve this task. All of the methods involve encouraging the cells to lyse, or break apart. Cell homogenization can be achieved through various methods, including mechanical disruption, liquid homogenization, sonication, or manual grinding. Continue reading for a brief overview of each method of cell homogenization.

Mechanical Disruption

Mechanical disruption involves the use of rotating blades. These blades work to grind and disperse cells, and they are most effective at homogenizing tissues such as liver.  Rotor-stator homogenizers are one of the best homogenizing tools used in mechanical disruption and can homogenize samples in the volumes from 0.01 milliliters to up to 20 liters, depending on the type of motor that is used. Sample loss is typically minimal, and small amounts of samples and tissues can easily be homogenized using this method.

Liquid Homogenization

Liquid homogenization is the most widely used cell disruption technique, especially with small volumes and cultured cells. In this method, cells are lysed by the action of being forced through a small space, which acts to shear the cell membranes. There are several types of liquid homogenizers on the market, including Potter-Elvehjem homogenizers, french presses, and the dounce homogenizer.

Sonication

Sonication is a type of physical disruption used to lyse cells. This method uses high frequency sound waves to lyse cells, bacteria, and other types of tissue. The sound waves are delivered via a probe that is immersed in the liquid cell suspension. This method, while common, is often time consuming and is best suited for volumes of less than 100 mL.

Manual Grinding

Manual grinding, while one of the most time consuming methods of cell homogenization, is also the most common. In this method, a mortar and pestle is used to manually grind cells. While not suitable for extremely large volumes, this method is the most effective at breaking apart plant tissue cells.

BEE International offers a wide variety of high pressure homogenizers to meet the needs of virtually any industry. Our technology is well suited for nano emulsions, cell lysis, uniform particle reduction, and other related applications.

Contact us today to learn more about how our line of homogenizers can help with your company’s needs.

Also, be sure to check out our FREE eBook on 7 key factors to consider when choosing a cell lysis method

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3 Advantages of Homogenizers for Pharmaceutical Products

Posted by Deb Shechter on Jun 20, 2017 11:00:00 AM

Homogenizers for Pharmaceutical ProductsHomogenization – also known as cell fractionation or micronization – is the process of dividing particles into microscopic sizes, ranging anywhere from 0.5 microns to 2 microns, depending on the application. Homogenizers play an important role in the pharmaceutical industry and are commonly used for dispersions, emulsions, particle size reduction, and cell rupture.

Keep reading to discover the advantages of homogenizers for pharmaceutical products in the ever-growing pharmaceutical industry.

1. Reduced Particle Size 

Effective homogenization results in a smaller particle size and more even distribution of active ingredients. For topical pharmaceutical products, such as medicated creams, lotions, and ointments, this allows for those medications to absorb more rapidly into the skin. A reduction in particle size increases the surface area of critical (and often expensive) active ingredients, which allows for an even dispersion of the active ingredients in the product. This in turn increases the efficacy of pharmaceutical products and lowers cost as well. 

2. Increased Stability of Pharmaceutical Products 

High-quality homogenizers have the ability to reduce the particle size of critical active ingredients, which in some cases can help improve the stability of these otherwise unstable active ingredients. Some critical active ingredients used in the pharmaceutical industry are solid at room temperature and only moderately soluble in water or organic solvents. Effective homogenization can reduce these otherwise difficult to work with active ingredients into a small enough size that they have increased solubility in these mediums. Additionally, many of these mediums can work further to increase the shelf life and stability of the active ingredients. 

3. Increased Reliability in Manufacturing Settings

BEE International has a number of first-class homogenizers that can meet the needs of manufacturers in the pharmaceutical industry. Our industrial homogenizers are designed for cGMP manufacturing and offer reliability suitable for all industries, including those with a 24/7 operating schedule. Our proprietary software offers touch screen guided operation, data collection, security, on-line maintenance schedules and alarms, and configurable recipes and capacities. 

BEE International industrial homogenizers and high pressure homogenizers are manufacturing pharmaceutical, chemical, life sciences, food, cosmetic products, and more. Contact us today to discuss the benefits our homogenizers can bring to manufacturing your company’s products.

For more information about the Advantages of BEE Homogenizers for the Pharmaceutical Industry, download our FREE eBook today:

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Local vs. Systemic Steroids: What's the Difference?

Posted by Tal Shechter on Jun 13, 2017 2:30:00 PM

Local vs. Systemic SteroidsWhen most people think of steroids, images of elite athletes using synthetic hormones to gain a competitive advantage may come to mind. However, steroids – more often referred to as corticosteroids in medical circles – are often used to serve a very different purpose. There are numerous varieties of corticosteroid medications, including cortisone, methylprednisolone, and prednisone.

Steroids work by both reducing inflammation and decreasing immune system activity, and they are commonly used to treat a variety of diseases, including rheumatoid arthritis, eczema, asthma, and a host of other inflammatory ailments.

Steroids come in several different forms – local and systemic.  The form of steroid used is dependent on the ailment that is being treated, as well as the desired outcome.

Local steroid medications are best suited for ailments where a targeted approach is desired. These types of steroids can be introduced directly to the area in question and include eye drops, ear drops, skin creams, and joint injections.

Systemic steroids are best suited for ailments that require treatment throughout the entire body. Systemic steroids circulate throughout the bloodstream and reach every area of the body. They include oral medications as well as medications that are delivered intravenously or intramuscularly.

For both local and systemic applications, homogenization is an important process step to consider in industries that manufacture steroid-containing topical creams, ointments, and intravenous drugs.

In all applications, the even dispersion of active ingredients is critical to ensuring efficacy and decreasing manufacturing costs. Oral medications, for example, require homogenization and micronization of particles to ensure consistency throughout the product. Similarly, systemic steroids require the use of a homogenizer to ensure even dispersion and dissolution of the particles that make up the active ingredients.

BEE International offers a number of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, and biotech. Our homogenizers can meet the needs of virtually any environment – from small R&D settings and pilot plant operations all the way to 24/7 manufacturing environments.

For small sample sizes, as are often seen in laboratory and R&D settings, our Nano DeBEE is an excellent choice. This mechanical homogenizer uses multiple forces, including cavitation, turbulence, and pressure to create microscopic particles that can easily be dissolved in a variety of mediums, including liquids, creams, and organic solvents.

Contact us today to discuss the numerous benefits our homogenizers can offer to manufacturing your company's products. 

Also, be sure to check out our FREE eBook on how to achieve efficient and consistent particle size reduction

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3 Common Options for High Pressure Homogenizer Products

Posted by David Shechter on May 19, 2017 12:30:00 PM

homogenizer productsHomogenization, also known as particle size reduction, is a powerful technique that is used across a number of growing industries, including pharmaceutical, biotech, cosmetic, and engineering. This process involves forcing materials through a small orifice to disrupt, break, or otherwise reduce the size of particles within any given material. And while the process of homogenization may seem relatively simple, with it comes huge benefits: reduced costs, higher quality, increased customer satisfaction, and immense time savings. With benefits like those, its no wonder that more and more industries are looking to invest in a homogenizer of their own. However, before choosing a homogenizer for your needs, it is important to learn more about the benefits of this technique. And when it comes to products that benefit from homogenization, the answer may surprise you. Keep reading to learn more about 3 common options for high pressure homogenizer products.

Health, Beauty, and Cosmetic Creams

Lotions, anti-aging creams, and cosmetic creams can all benefit from the process of homogenization. Many creams are emulsion-based, and the right homogenizer can create these emulsions effortlessly, seamlessly, and consistently. Homogenization also allows industries to use water as both a solvent and diluent – something that is not easily achievable through other methods. With water acting as both a solvent and diluents, particles are able to dissolve rapidly and completely in just about every medium.

Pharmaceutical Drugs

In addition to creams, pharmaceutical products can also benefit from homogenization. The process of homogenization allows for the highest quality pharmaceutical drugs to be produced safely, reliably, and inexpensively. Particles that have had their sizes reduced are able to more readily and easily dissolve in solution, which allows for better and more effective drug delivery, more even dispersion of active ingredients, and higher safety and quality.

Beverages

Perhaps the most surprising benefit of homogenization involves the creation of beverages. Beverages can reap huge benefits from the processes of both homogenization and pasteurization. These processes often work hand in hand, and result in beverages that are full of nutrients, safe to consume, and are visually appealing, not to mention tasty! Another benefit of homogenization is increased shelf life among these types of products.

Homogenization offers a number of huge benefits, and this article barely scratches the surface. To learn more about the many benefits of homogenization, as well as the homogenization equipment available through BEE International, please contact us today.

For more information on cell lysis methods and how to choose the right one for the product you want, download our FREE eBook:

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How to Select a Homogenizer for Particle Size Reduction

Posted by Deb Shechter on May 17, 2017 12:30:00 PM

select homogenizer for particle size reductionHomogenization, also known a micronization, or more simply, particle size reduction, is a powerful technique used across a number of growing industries: cosmetic, pharmaceutical, biotech, and even food! The next time you spread mayo on your sandwich, use anti-aging cream, or take medication for your pounding headache, you can thank the powers behind homogenization. Aside from creating useful and effective products, homogenization has other benefits: it creates uniform and consistent products with minimal amounts of effort, it saves money, and it increases overall customer satisfaction. With all of those benefits, it’s no wonder that more and more industries and businesses are looking to invest in a homogenizer of their own.

However, before selecting a homogenizer to meet your particular needs, it can be useful to understand what you should be looking for in a homogenizer. Continue reading to learn more about how to select a homogenizer for particle size reduction.

What type of product do you need?

The first thing to think about is what type of product you are aiming to create. The homogenizer you choose will vary based on whether you want to use it for a specific product or for more general use. The first step in choosing a homogenizer is identifying several key products that you aim to produce using the machine. This will help guide you in the right direction in choosing the most appropriate machine for your needs.

Intended procedure and/or results

Once you have an idea of the product or products that you would like to create, you will be able to select the procedure you intend on using. From quick mixing to the lysing of tissues and other delicate materials, knowing which procedure you will use will determine which features and technical capabilities you will need in a homogenizer.

Technical operations needed

Now that the product type and procedure have been identified, it is necessary to determine the technical operations to look for in a homogenizer. Depending on whether your process requires mechanical forces (like shear, cavitation, or impact), high pressure, temperature change, or another parameter altogether, it is important to identify the technical operations needed to ensure that you choose the right machine for your needs.

We at BEE International offer a number of homogenizers to suit virtually any need. We are excited to help you begin your next big homogenization project. Please contact us today to learn more about the innovative homogenizing equipment that we have to offer.

For more information on how to achieve efficient and consistent particle size reduction, download our FREE eBook:

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Choosing the Right Laboratory Homogenizer

Posted by David Shechter on Apr 27, 2017 12:30:00 PM

laboratory homogenizerHomogenization, defined as micronization, or more simply put, particle size reduction, plays an important role in a number of industries, including pharmaceutical, biotech, cosmetic, and even food. The next time you apply anti-aging cream or moisturizer, drink an ice-cold and creamy glass of milk, or take a prescription painkiller, you can thank the powers of homogenization! With the wide variety of uses, it’s no wonder that more and more industries are looking to purchase a homogenizer of their own. But before jumping into a purchase, it is important to learn more about your options. BEE International is here to help. Continue reading to learn about the selection of laboratory homogenizers that we have to offer.

Nano DeBEE Laboratory Homogenizer

Our Nano DeBEE Laboratory Homogenizer is our smallest in our line of laboratory homogenizers, but even within this small piece of equipment, you can rest assured that it is capable of a lot. This cost effective bench top unit offers a reliable and consistent process for virtually any laboratory setting. With features including a state of the art reservoir for small volumes, an adjustable process pressure gauge, a heat exchanger, and even a back pressure gauge, it is easy to see why this is a popular choice for an entry level laboratory homogenizer.

Micro DeBEE Laboratory Homogenizer

Our Micro DeBEE Laboratory Homogenizer is an air-operated, compact, bench top unit that is suitable for a broad range of applications, including cell disruption, particle size reduction, work with polymers and liposomes, and the creation of nano emulsions, micro emulsions, nano dispersions, and micro dispersions. If you are looking for a piece of equipment that offers a bit more capacity and power than the Nano DeBEE Laboratory Homogenizer, this is the right choice.

Mini DeBEE Laboratory Homogenizer

Last, but certainly not least, is our Mini DeBEE Laboratory Homogenizer. This cost effective unit is suitable for both laboratory and R&D work, as well as pilot plant and industrial production. It offers the same features as the Nano and Micro DeBEE Laboratory Homogenizers with a lot more capacity and power. Other features include pressures up to 45,000 psi, 100% guaranteed scalability of results, PLC control with a digital display, and a 1-year factory warranty.

The world of laboratory homogenizers is vast, but that doesn’t mean it has to be complicated! All our our purchases come equipped with a robust 1-year warranty, as well as lifetime training for new employees and students. We would love to work with you on your next big project — contact us today for more information on these homogenizers, as well as other products in our wide line of homogenizers.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Choosing the Right Pilot & Industrial Homogenizer

Posted by Tal Shechter on Apr 18, 2017 12:30:00 PM

choosing right pilot and industrial homogenizerHomogenization, also known as particle size reduction or micronization, is a technique that is widely used across a number of industries: cosmetic, food, pharmaceutical, and biotech. This powerful (and useful) technique allows manufacturers to create uniform creams, visually pleasing sauces, and effective pharmaceutical painkillers, just to name a few applications. And without the innovative technology found within homogenizers,  few of the aforementioned products would be as readily available as we’ve come to expect.

With that, it is no surprise that the task of choosing the right homogenizer for the job is an often daunting task. With so many options on the market to choose from, it is easy to get overwhelmed. However, if certain key points are kept in mind, choosing the right homogenizer for your pilot or industrial plant can be simple. Continue reading to learn more about the pilot and industrial homogenizers offered by BEE International.

DeBEE 2000 Pilot Plant Homogenizers

The DeBEE 2000 line of homogenizers represent the smallest available units that offer all available process configurations, including dual feed, dual jet, and automatic clean in place (CIP) technology.  These homogenizers also offer a number of powerful validation packages, as well as hazardous environment protection, feed solutions, and additional process monitoring.

DeBEE 3000 Industrial Homogenizers

The DeBEE 3000 line of homogenizers are our entry level production scale models, suitable for both laboratory work as well as scaled up production work. No matter the needs of your industry, the DeBEE 3000 line of homogenizers are suitable for your process. These homogenizers offer unmatched particle size reduction with maximum efficiency for micro/nano emulsions and particles, as well as the highest yield in cell rupture in the shortest amount of time.

DeBEE 4000 Automated Industrial Homogenizers

The DeBEE 4000 line of homogenizers represent the most powerful line of homogenization equipment that BEE International has to offer. This series of equipment offers the highest levels of process controls and automation, as well as integration with plant controls and compliance with CFR 21 part 11 requirements. In addition to other powerful benefits, these homogenizers offer various security modes and authorizations, alarms to ensure system safety and the correct course of action, SCADA compliance, and sanitary design and features suitable for even the most stringent of fields.

To learn more about the line of homogenizers offered by BEE International, please contact us today. We look forward to working with you on your next homogenization project.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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3 Key Features of Intensifier Pumping Systems

Posted by David Shechter on Apr 12, 2017 12:30:00 PM

intensifier pumping systemsHomogenization, or particle size reduction, is, as the name suggests, the process of decreasing the size of particles. This popular technique is used in numerous industries for the manufacture of a wide variety of products, from pharmaceutical painkillers to anti-aging cream, and just about everything in between. But in order for homogenizers to do their job, the right technology is necessary. One such technology, one that is at the heart of our homogenizers, is Intensifier Pumping Systems.

We at BEE International have our own proprietary pumping system, designed for heavy duty, leak free, and long life cycle operation. This rugged system is designed for use in a wide variety of industries, including cosmetic, biotech, and even food. Our pumping system is made up of intensifiers that are actuated and synchronized by PLC – Programmable Logic Controller – to deliver constant pressure and flow through the homogenizing cell. Continue reading to learn more about our intensifier pumping system, as well as three key features that makes this technology the top of its class.

High Pressure Cylinder

The high pressure cylinder, also known as the HP cylinder, takes in product that flows from the system inlet port. During the suction stroke of the pump, it enters the HP cylinder, where it is then pushed out to the emulsifying cell (EC) during the power stroke of the pump.

Isolator

The isolator piece holds the hydraulic cylinder and the high pressure (HP) cylinder together, all while preventing cross contamination between the product fluid and hydraulic fluid.

Hydraulic Cylinder

Finally, the hydraulic cylinder, which is powered by the hydraulic power unit, takes in pressurized oil and pushes the hydraulic piston, which causes the piston to reciprocate.

These three sections of the intensifier pumping system work together to optimize the homogenization process, allowing for a process that is reliable, repeatable, and produces high-quality results. Other benefits of this technology include the following:

  • 5 different hydraulic cylinder sizes
  • 3 different high pressure cylinder sizes
  • Operating pressures of up to 45,000psi
  • Advanced intensifier controls allow for automation at the push of a button
  • Variable operating speeds to allow for the optimization of the process based on requirements
  • Ability to handle highly viscous materials
  • Long service life
  • Clean in Place (CIP) technology

To learn more about our proprietary intensifier pumping system, as well as more information on our wide variety of homogenizers, please contact us today. To learn more about the technology used here at BEE International, click here.

For more information homogenization and how to choose the right cell lysis method, download our FREE eBook:

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Small Particle Sizes: 3 Key Benefits

Posted by David Shechter on Apr 5, 2017 11:30:00 AM

small particle sizef you work in the fields of biotechnology, cosmetics, pharmaceuticals, drugs, or food, chances are you have a good idea of what homogenization is. And if that term sounds foreign to you, you may be wondering what the big deal is about homogenization. No matter which of the two categories you fall into, this article will provide useful information to gain more knowledge and insight into this powerful process.

So what is homogenization, exactly? The definition is quite simple: homogenization is the process of reducing the particle size of a product. Whether you are creating pain relieving pills, anti-aging moisturizing cream, or a cold glass of milk, homogenization plays a powerful role in the manufacture of the components that make up these, as well as many other finished goods. While the reduction of particle size may seem like an action with limited benefits, that is just not the case. Continue reading to learn more about the key benefits of small particle sizes.

Greater Product Stability

When manufacturers achieve a tight distribution of particles – a byproduct of successful homogenization – the benefits are endless. A tight distribution of particles allows for greater product stability, which then allows for a longer shelf life, optimized particle characteristics, uniform temperature and reactive qualities, and higher overall product quality. This, in turn, leads to increased sales and increased customer satisfaction.

Manufacturing Efficiency

Small particle sizes also allow manufacturers to build a process that is cost effective and efficient, due to the fact that fewer passes need to occur. In a world of tight budgets and a growing desire for proven ROI within corporations, any and all efficiencies within the manufacturing process are welcomed and desired.

Consistent Results

Finally, reduced particle sizes of particles that comprise finished goods allows manufacturers to achieve consistent, precisely controlled, and repeatable results. The importance of consistent results is far-reaching; consistent results allow processes to be scaled up from a smaller laboratory setting to pilot plant production and even full-scale industrial operations.

BEE International: Homogenizers that provide quality results

If quality results are what you’re looking for, look no further! Our line of homogenizers at BEE International possess all of the features you are looking for at a price that will certainly fall within your budget. By utilizing the powerful forces of turbulence, cavitation, shear, and impact, our homogenizers guarantee results that are repeatable, scalable, and are the highest of quality. To learn more about our homogenizing equipment, please contact us today. We look forward to working with you on your next large project.

For more information on how to achieve efficient and consistent particle size reduction, download our FREE eBook: 

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