Making the Right Choice: Homogenizer Manufacturers

Posted by David Shechter on Jul 31, 2018 11:30:00 AM

choosing high pressure homogenizerShopping for certain products is easy. If you want a fast food hamburger, you have a few well-known establishments from which to choose. If you’re looking to purchase some products to stain a deck or tend to weeds in your lawn, you most likely go to your local hardware store or one of a couple bigger, nationwide home improvement stores.

Investing in a more expensive product often requires more research and comparison. Usually, you can read customer reviews online or find ratings published by consumer organizations. When purchasing a homogenizer, however, it may be harder for you to obtain the advice needed to make the right decision.

First, let’s do a little refresher on homogenization. The primary methods used for homogenization include ultrasonic, mechanical and high-pressure, and homogenizers are used across multiple industries, such as:

  • Pharmaceutical: vaccines, antibiotics, cancer treatment and medicinal creams.
  • Food and Beverage: mayonnaise, ice cream, cream liqueurs, salad dressings, dairy products and more.
  • Biotech: creation of cost-effective medicines, modification of microorganisms, synthesization of chemicals and development of alternative biofuels.

Based on these details, the first step in finding a homogenizer manufacturer in asking yourself the following questions:

  1. Why do I need one?
  2. What differentiates one homogenizer from similar ones on the market?
  3. Does my product require a specific particle size?
  4. Which accessories are recommended and/or required for optimal performance?
  5. What motor power does my product require?
  6. Do I have a desired tube capacity and/or mixing speed?

By understanding the available options and what can best help you accomplish your specific homogenization goals, you are better equipped to select a manufacturer to meet your specific needs. It’s important to choose a manufacturer who will work with you to customize a homogenizer that delivers the best possible results. Some companies are able to customize the forces in their homogenizers to suit your application. Some even produce separate homogenizers for each phase of drug development.

Consistency is essential in homogenization, so employing the services of a manufacturer who aids you in reproducing reliable results is imperative. They should offer a homogenizer that is easy to scale and enables the product developer to quickly apply a wide variety of mixing techniques to a formulation. The manufacturer should have a reputation for reliability, offer customer referrals and provide you with at least once demonstration of their product(s).

Once you’ve decided on a manufacturer from which to purchase your homogenizer, factors to consider when choosing a brand and model include:

  • Sample types.
  • Maximum operating pressure. 
  • Mixing speed.
  • Processing setup. 
  • Processing range. 

 

BEE International: The Right Choice for the Best Reproducible Results

Our technology achieves superior results for nano emulsions, cell lysis, uniform particle reduction and related applications, and we offer homogenizers that are high-quality, customizable and reliable. Plus, we provide unparalleled customer service from demo to purchase and beyond. Contact us today for more information on our entire line of homogenization equipment.

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Six Tips for Ensuring Safety When Using Your High-Pressure Homogenizer

Posted by Deb Shechter on Jul 12, 2018 10:30:00 AM

high pressure homogenizerSafety first. It’s a phrase you hear fairly often, and although it may seem unnecessary to repeat, it’s especially important when working with large machines or those with many parts. When not used correctly, these machines can not only fail to produce an optimal product but also cause injury. 

Homogenizers fit into this category, so we’re offering the following tips on how to use yours and the samples it produces both safely and effectively:

1. Wear the appropriate protective equipment.

As with any such machine, these elements are designed to keep the user safe from moving parts and any hazardous chemicals. Whether it’s gloves, eye goggles or even ear plugs, investing in these accessories can keep you from damaging any part of your body, especially your eyes and ears. Some high-pressure homogenizers can reach 85 dBA and potentially cause ear damage.

2. Follow operating instructions and regulations.

There are safety laws and guidelines produced by unions and the government for a reason. These rules are designed to keep you safe while ensuring the machine you’re using is working as it was designed to do. To make sure you always have your high-pressure homogenizer’s instruction manual when you need it, keep it with the machine, and store a copy with your other important documents.

3. Use only the parts that came with your high-pressure homogenizer.

The parts that make up your high-pressure homogenizer are designed to work together and should not be substituted with another accessory or attachment. Failure to follow this rule may cause your product to work at a decreased level or even break, often voiding your warranty.

4. Avoid contact with the rotating shaft and homogenizing head.

Contact with either of these sharp parts can cause injury, so make sure you always switch the machine off before cleaning it or changing screens. Be especially careful when handling your high-pressure homogenizer after it has been contaminated with dangerous samples.

5. Let only trained operators handle your high-pressure homogenizer.

When installing or operating your homogenizer or simply doing maintenance on it, have only those trained to do so perform the task. Improper handling can cause both machine malfunction and minor injury to the handler.

6. Follow common electrical precautions.

Again, these rules are in place for a reason, and failing to follow such rules may result in electrocution or shock.

BEE International: Putting Safety First

At BEE International, our line of equipment is suitable for virtually every industry and can work in just about any environment, letting you focus on other important projects. Plus, we work with you to make sure you understand the appropriate safety precautions and provide training for all our products. To learn more, please contact us today.New Call-to-action

Homogenizers and the Forces That Drive Them

Posted by Deb Shechter on Jun 25, 2018 11:30:00 AM

forceForce sounds like a very scientific term, but it basically consists of pushing, pulling and gravity. Pushes and pulls set things in motion, while gravity pulls down everything on earth. The six kinds of forces that act on objects when they come into contact with one another are: normal, applied, frictional, tension, spring and resisting.

In high-pressure homogenization, mechanical forces enhance the effectiveness of utilizing extremely high operating pressures. The combination of four main forces – cavitation, high shear, impact and turbulence – are used with high pressure to achieve particle size reduction, cell lysis and/or effective emulsification.

Cavitation

Cavitation occurs when a high amount of pressure is exerted on a liquid sample. Pressure enables the liquid to achieve high kinetic energy, thereby increasing velocity. Also sometimes described as the formation of liquid-free spaces within a liquid, cavitation is especially useful for particle reduction and can be intensified or reduced by adjusting the size of a high-pressure homogenizer’s nozzle.

Although homogenization can be accomplished without cavitation, it increases the efficiency of the process. In the food industry, cavitation in homogenization breaks up large fat globules to create a stable emulsion for increased shelf life and improve taste and texture.

High Shear

High-pressure homogenizers work through shear force, which can be created when a tangential force is applied to a sample. Homogenization using high shear allows for even further reduction of particle size by mixing two normally immiscible phases, such as with water-in-oil (w/o) or oil-in-water (o/w) emulsions.

Many high shear mixers are used to reduce particle size, but high-pressure homogenizers are able to attain even higher shear rates. This is especially important when a dispersion is required.

Impact

The force of impact works in homogenization to reduce the particle size of solids into liquids and achieve lysis of difficult-to-disrupt cells and other materials though the use of grinding beads. Dounce and Potter-Elvehjem homogenizers use only the force of impact to lyse cells, while the French press counterpart adds in high shear. The ability of high-pressure homogenizers to combine multiple forces offers manufacturers better yield in fewer passes and a lower time requirement. Along with other mechanical forces, impact can be fine-tuned to accommodate a specific sample.

Turbulence

In the overall homogenization process, turbulent premixing is the stage designed to prepare a sample by mechanically loosening bonds. By high-pressure machines like stirrers and agitators putting a sample through turbulent premixing, the homogenization process is easier and more time-efficient.

Another influence in homogenization is process intensity; higher intensity is used to obtain smaller particle sizes in fewer passes. Though not all homogenizers are equipped with adjustable process intensities, those from BEE International allow for increased or reduced process intensity with only the turn of a dial.

BEE International: The Driving Force Behind the Best High-Pressure Homogenizers

Unlike other technologies which apply one mechanical force to mix a product, BEE technology utilizes all available mechanical forces to achieve optimum results. We synergistically combine and fine-tune these forces to produce the best possible product for you and let you produce a tight distribution of small, uniform particles every time. Contact us to learn more!

For more information on key factors to consider when choosing a cell lysis method, download our FREE eBook:

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Summer, Sunscreen, and Homogenization

Posted by David Shechter on Jun 13, 2018 11:30:00 AM

bee1For many people across the United States, the winter of 2017 was one of the coldest on record. Residents of the East Coast had to deal with multiple Nor'easters, shutting down airports and wreaking havoc on roadways.

For most of us, summer and the high temperatures that typically accompany it are definitely welcome. Kids are out of school, baseball games are being played and swimming pools are being opened and prepped for lazy summer days.

With the arrival of summer, though, comes a reminder about the dangers of getting too much sun. More people are diagnosed with skin cancer annually in the U.S. than all other cancers combined, and the annual cost for treating skin cancers in this country is an estimated $8.1 billion.

Skin cancer may be prevented or at least minimized through the regular use of sunscreen. In fact, scientific evidence supports the benefits of using sunscreen to reduce short- and long-term damage to the skin from the sun’s rays.  

High-pressure homogenization is a preferred method for improving the production of cosmetic creams or lotions, including sunscreen, because it offers the following benefits:

Potent Particle Size Reduction

By forcing a sample through a narrow space while applying high pressure and multiple mechanical forces, including cavitation, shear, impact and turbulence, high-pressure homogenization more effectively decreases particle size. This reduction, or micronization, creates a more homogenous mixture, provides better active ingredient dispersion and stabilizes product emulsions. It’s especially beneficial for creams, lotions and other cosmetic products because of the positive effect on the quality of these items. 

Enriched Texture and Consistency

High-pressure homogenization is often preferred over other methods because of it’s capability to create a product that is uniformly mixed. This leads to smoother texture and enhanced consistency, which is essential for beauty creams and moisturizing lotions because they have to have a combination of the right texture and consistency in order for the skin to be able to effectively absorb them. 

Strengthened Emulsion Stability

Semi-solid products such as lotions and creams are comprised of emulsions, which are a mixture of two immiscible liquids. Micronization of droplets acts to eliminate the separation of water phase of homogenization, resulting in a more permanent mixture of oil and water. This permanence extends the shelf life of these semi-solid products and improves their appearance through consistent coloring.

BEEI: Homogenizers for High-quality Creams and Lotions

If you’re searching for a cosmetic homogenizer to meet your laboratory and/or production needs, make sure you choose one that’s high quality and includes a combination of capabilities. Whether your product is a cream, lotion, makeup or personal care item, opting for a customizable high-pressure homogenizer will only improve and enhance its effectiveness.

Contact us today to learn more about our full line of homogenizers and what they can do for you.

For more information on homogenization and how to achieve efficient and consistent particle size reduction, download our FREE eBook:

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Homogenization and the Industries That Use It

Posted by Tal Shechter on May 29, 2018 2:00:00 PM

bee2Many people go to a local store to buy food, personal care products, medicine and other items. However, most of us don’t spend any time considering what went into the production of these items. In many cases, it likely involved homogenization.

Homogenization is a process utilized for particle size reduction. It works by forcing a sample through a narrow space, and multiple forces, including turbulence and cavitation in addition to high pressure, can act on the sample to create a high-quality product. It can be used on many different types of material, such as plant, food, soil, tissue and more. Plus, it provides benefits for multiple applications, such as high-pressure pasteurization, dispersions, micro/nano emulsions and cell disruption.

Although many other types mixing machines exist, homogenizers are scalable, and their use of multiple mechanical forces instead of just one results in stable, uniform and consistent products. They are used in a wide variety of research and scientific uses and by many industries that require the use of active ingredients because they reduce active ingredients to a small enough size to ensure a thorough dispersion throughout the medium produced.

Pharmaceutical

Powerful mixing and particle size reduction are key techniques among pharmaceutical products. In the pharmaceutical industry, researchers use homogenizers during laboratory research and in clinical trials and manufacturing for products including vaccines, antibiotics, cancer treatment and medicinal creams. Benefits of homogenization for pharmaceutical products include improve delivery of active pharmaceutical ingredients, increased digestibility, lengthened shelf life and improved reliability in manufacturing settings.

The most important uses for homogenizers in the pharmaceutical industry are particle size reduction, scaling for drug development and synthesis of essential drug components. Though other mixing methods exist, homogenization is the most scalable, resulting in increased cost savings, lower time requirements and a decrease in the likelihood of failure for the product for which its used.

Food and Beverage

Many people identify the use of homogenization in the food and beverage industry with milk; it gives milk a longer shelf life and makes it more stable and visually pleasing. Homogenization is primarily used in the food and beverage industry to help manufacturers improve the composition and quality of their products and ensure their end products meet standards for visual appearance, texture and taste. 

Because homogenization utilizes pressure instead of heat, valuable nutrient content and flavor are preserved, chemical structures are stabilized and food processing outcomes are improved. It is a preferred method for producing emulsions, suspensions and other products that require a liquid suspended in another liquid or a small particle size. These products include mayonnaise, ice cream, cream liqueurs, salad dressings, dairy products and more.

Biotech

The biotech industry is comprised of the fields of cellular biology and molecular biology. Homogenizers are most commonly used in this industry to achieve effective cell rupture, enhanced particle size reduction and nanoparticle production. Although they decrease particle size, they ensure that a composition is equal throughout without compromising the overall molecular makeup of the sample.

Homogenizers also can be used to create cost effective medicines, modify microorganisms, synthesize new chemicals and develop alternative biofuels. In the case of cell disruption, they allow for a variety of cells, including E. coli, yeast, bacteria and delicate animal tissues, to be ruptured to recover the contents of essential cells.

BEE International: First on the Road to Reliability

BEE International offers homogenizers that are both high-quality and reliable. Our line of equipment is suitable for virtually every industry and can work in just about any environment. Contact us today to learn how our products can maximize your homogenization processes.

To learn more about 7 key factors to consider when choosing a cell lysis method, no matter the industry you're in, download our FREE eBook:

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Pharmaceutical Equipment Manufacturers: Five Questions to Ask Before Purchasing a Homogenizer

Posted by David Shechter on May 21, 2018 11:00:00 AM

pharmaceutical equipment manufacturers homogenizerBuying an automobile or house may be a complex process, but you often want to perform detailed research before making such a substantial purchase. You want to ensure your purchase has the capabilities you require, fits within your budget and offers a good investment.

For manufacturers of pharmaceutical equipment, doing research before buying a homogenizer or any other sizable item necessary for production is key to finding the right one. Though this process many seem time-consuming, you’ll end up with a product that best fits your needs and gives you the most benefits. Following are ten questions to ask before buying a homogenizer:

Why do I need one?

Though homogenizers are valuable tools for manufacturers in multiple industries, different models typically address different needs. For instance, maybe you need a homogenizer to mass-manufacture a product that has been approved for market. Or, perhaps you’re conducting research and development and need to disrupt yeast cells. At BEE International, we produce separate homogenizers for each phase of drug development. Make sure the product you choose is best suited to your specific business needs.

What differentiates one homogenizer from similar ones on the market?

In your research for a homogenizer, be sure to ask each manufacturer about their product’s specific capabilities and benefits. Their customer support personnel should be able to articulate any unique functions and/or specifications their products have and define ways it may be more cost-effective than competing products.

Does my product require a specific particle size?

To purchase a homogenizer which provides maximum laboratory output, you should ensure you know the required consistency in texture and size for your product to achieve safety and efficacy. Most pharmaceutical products, including vaccines, inhalants and anesthetics, need to be synthesized using a specific particle size. Many high-pressure homogenizers are able to produce emulsions, dispersions and suspensions at particle sizes of 100 µm or higher, but only a select few can achieve a size of down to 0.1 µm.

Which accessories are recommended and/or required for optimal performance?

Many times, a homogenizer without a lot of bells and whistles will perform the job for which you selected it well. However, some accessories are designed to offer benefits such as time savings, improved process accuracy and enhanced process efficiency. For example, deflector heads can facilitate homogenization of viscous material, generator probes can prevent cross-contamination and pre-assembled bead kits can make the process much easier. Check with each manufacturer to see if any specific accessories are needed for their homogenizing product to run at its highest possible level.

Do you have a demo machine we can test to see if your product meets our needs?

Before you purchase any homogenizer from any manufacturer, it’s important to try each one out to make sure it’s the best fit for your laboratory. For instance, if you handle high volumes of samples, you should try a homogenizer with a high motor capacity for optimal processing efficiency. If you have a desired mixing speed, you should examine homogenizers that let you easily achieve and maintain this speed or change it as necessary.

Other questions to ask when looking to purchase a homogenizer should center around company reputation, product warranties, level of customer service after purchase, user training and education, output capacity and ease of use. Taking the time to select the homogenizer best suited to your needs will be worth the effort.

BEE International: Trust Us with Your Homogenization Needs

At Bee International, we have extensive experience in the challenges our pharmaceutical customers face as they transition from concept, R&D, clinical trials and all-important FDA approval to manufacturing. Plus, we’re trusted by pharmaceutical researchers and laboratory managers around the world. Contact us today to learn more about our complete line of homogenizers.

For more information on the advantages of BEE homogenizers for the pharmaceutical industry, download our FREE eBook:

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Particle Size Reduction: Processes and Products

Posted by Deb Shechter on May 8, 2018 2:30:00 PM

particle size reductionBigger is not always better. For instance, many electronic gadgets that have come out over the past few years have a smaller, more streamlined design. Most people want to lose weight to become smaller. Also, I’m glad pests like spiders and cockroaches are as small as they are.

Multiple industries and manufacturers need to be able to reduce the size of particles to achieve their preferred end-product. It affects a product’s color, taste, chemical reaction, density and more. For example: reduced particle size enables creams and lotions to absorb into the skin more rapidly, which is extremely important in the pharmaceutical and cosmetic industries.

Key benefits of particle size reduction include:

  • Increased dissolution rate

  • Improved drug delivery

  • Cleaning product health and safety

  • Controlled rate of reaction

  • Greater sedimentation stability

  • Consistent product texture and appearance

  • Improved mineral processing 

Preferred Product for Particle Size Reduction

One of the most widely utilized methods for particle size reduction is high-pressure homogenization. It uses mechanical force to break down particles or droplets in a liquid into smaller and more uniform sizes, resulting in a dispersion, which is where fine particles of one substance are scattered throughout another substance. Dispersions can be further classified into solutions, suspensions and colloids, a mixture somewhere between a solution and a suspension.  

Some high-pressure homogenizers can reduce particle size to as small as a single-digit nanometer. Plus, they ensure the composition is equal throughout, and the overall molecular makeup of the sample isn’t compromised.

Selection Criteria

How do you know what homogenizer is best for your company’s specific needs? The first consideration is what type of product you need. Which one you select will vary based on whether you want to use it for a specific product or for more general use. identifying the key product(s) you want produce should help guide you in choosing the most suitable homogenizer.

Once you narrow down the product(s), you’ll want to decide what features and capabilities you want in a homogenizer. Depending on whether your product(s) and process requires mechanical forces (like shear, cavitation or impact), high pressure, temperature change or another parameter altogether, you should identify the technical operations needed to make sure you choose the right machine for your needs.

The BEE International Difference

Unlike a hammer mill which uses only one mechanical force (impact), BEE International’s patented homogenization technology utilizes all available mechanical forces. We synergistically combine and fine-tune all available mechanical forces, including turbulence, cavitation, shear, impact and process intensity, to produce the best possible product for you. In addition, we produce a tight distribution of small, uniform particles every time.

Depending on your product, benefits of our products include a longer shelf life, increased bioavailability, improved sensory characteristics and greater productivity along with lower manufacturing costs due to fewer passes. Our laboratory, pilot and industrial homogenizers all produce reliable and consistent particle size reduction. 

Contact us today to see how we can meet your homogenization needs! To learn more about how to achieve efficient and consistent particle size reduction, download our FREE eBook:

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Oil-in-Water and Water-in-Oil Emulsions: What's the Difference?

Posted by Deb Shechter on Apr 24, 2018 10:30:00 AM

oil in water and water in oil emulsionsYou’ve no doubt heard the phrase “Oil and water don’t mix.” It’s basically a way of saying certain items or people do not go well together. However, oil and water can mix with the right ingredients – specifically, emulsifiers. Emulsifiers prevent oil and water from separating by establishing a barrier that protects the droplets.

When oil and water are mixed powerfully, they form either oil-in-water (o/w) or water-in-oil (w/o) emulsions. In o/w emulsions, oil is dispersed in a continuous water phase, while in w/o emulsions, water droplets are dispersed in oil. The result of an emulsion of oil and water mix is depended on the volume fraction of both phases and the kind of emulsifier utilized. You can actually tell the difference between the two by measuring the electrical conductivity of the emulsion. If there is no conductivity, it’s an w/o emulsion.

Both o/w and w/o emulsions have unique applications and chemical properties, and you can better choose the type you want to use if you know more about these differences. In this blog, we’ll provide some characteristics of o/w and w/o emulsions and describe some of the differences between the two.

Oil-in-Water Emulsions

Used in moisturizing products and food products such as milk, mayonnaise and vinaigrette, o/w emulsions contain a low oil concentration. They are mixable with water, non-greasy, non-occlusive and will absorb water. The dispersion medium in these emulsions is water; o/w emulsifiers keep oil drops packed in water.

Water-in-Oil Emulsions

These emulsions are utilized in products including butter, margarine, cold cream and cod liver oil and are especially useful in products designed for dry or sensitive skin. Common w/o emulsifiers are sorbitan stearate, polyglyceryl oleate, lecithin, sorbitan monooleate and lanolin. Sometimes referred to as an inverse emulsion, w/o emulsions mix more easily with oils and have a high oil concentration. Producing w/o emulsions is more difficult than developing their o/w emulsions.

Following are three additional differences between o/w and w/o emulsions:

1. Suspended vs. continuous phase

The biggest difference between o/w and w/o emulsions is which phase is suspended and which is continuous. Oil and water are normally immiscible, but with proper mixing and stability agents, a permanent mixture, or emulsion, can be achieved. Smaller droplet sizes will enhance the effectiveness of either system; this may translate to increased bioavailability in pharmaceutical products or extended shelf life in food/beverage products.

2. Type of product that can be created

The chemical nature of an o/w emulsion is distinct from that of a w/o emulsion; each is most effectively used in different products. O/w emulsions are the basis of water-based products; in the pharmaceutical industry, they can be found in creams like moisturizers and topical steroid products. In contrast, w/o emulsions make up oil-based products like sunscreen and most makeup.

3. How to achieve stability 

Stability is key when considering an emulsion synthesis technique; without it, the two phases will separate, and the product will have lower function. All emulsions require an emulsifier to assist with stability. O/w emulsions typically require more than one emulsifier, and they can be acquired separately or in a pre-mixed cocktail. In contrast, while w/o emulsions only require one emulsifier, there is a limited number from which to select because the hydrophilic balance must be in a narrow range. 

Emulsions, emulsifiers, homogenization and other terms can be confusing, but at BEE International, we can steer you in the right direction based on your specific business needs. Simply contact us to learn more!

Check out our FREE animation on how our technology can be customized for your application for efficient and consistent results:

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High-pressure Homogenizers: Enhancing Oil Emulsification

Posted by Deb Shechter on Mar 30, 2018 10:30:00 AM

high-pressure homogenizersYou might not think your daily life involves emulsions unless you work in a scientific field. However, emulsions and the products of which they are a part are found in a variety of industries, from pharmaceuticals and food manufacturing to metal processing and more. For example, milk and butter are emulsions found in daily life, and emulsions are responsible for enhancing both the textural and visual properties of medicated creams.

So what exactly is an emulsion? Basically, it’s a mixture of oily and watery liquids. There are two primary kinds of emulsions: oil suspended in water (o/w) and water suspended in oil (w/o). Both are inherently unstable and require force and functional chemicals, otherwise known as emulsifiers, to break apart oil droplets in order to mix with watery liquid. Following are three main differences between o/w and w/o emulsions: 

Suspended vs. continuous phase

Probably the most basic yet significant difference between o/w and w/o emulsions is which phase is suspended and which is continuous. Oil and water are normally immiscible, but a permanent mixture or emulsion can be achieved with the use of proper mixing and stability agents. In this case, smaller droplet sizes improve the effectiveness of either system, which may translate to increased bioavailability in pharmaceutical products or extended shelf-life in food/beverage products.

Type of product that can be created

O/w emulsions are the basis for water-based products; in the pharmaceutical industry, they can be found in creams like moisturizers and topical steroid products. W/o emulsions, though, form oil-based products such as sunscreen and many types of makeup.

Method used to achieve stability

All emulsions, whether w/o or o/w, require an emulsifier to assist with stability. O/w emulsions typically require more than one emulsifier, and they can be acquired separately or in a pre-mixed cocktail. In contrast, while w/o emulsions need one emulsifier, there are a limited number from which to select because the hydrophilic balance must be in a narrow range (3-6).

Again, due to the fact that water and oil are immiscible, powerful mixing is essential to conducting oil emulsification. Therefore, specialized machines such as high-pressure homogenizers, which work by forcing a sample through a narrow space and employing multiple forces, including turbulence and cavitation in addition to high pressure, are preferred. They not only impart high shear but also are able to reduce particle sizes much more efficiently than other blending and emulsification methods. In fact, high-pressure homogenizers can reduce droplet size to under one µm, produce more consistent emulsions and reduce creaming rate, thereby boosting the shelf-life of the emulsions.

Additional benefits of high-pressure homogenization for oil emulsification include production of stable emulsions, improved product consistency, shelf-life, texture, color and flavor and the ability to overcome the resistance caused by two immiscible liquids. Also, most high-pressure homogenizers currently manufactured offer reduced maintenance and reduced vibration and noise.

BEE International: Bringing the Benefits of Homogenization Straight to You

We know there are other providers of homogenization equipment, but at BEE International, our expertise, industry experience and level of customer service place us above the rest. Whatever your business needs, we have the product(s) to meet and exceed them. For more information, please contact us today.

For more information on how to achieve efficient and consistent results for your application, check out our FREE animation:

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Lessons on Selecting a Laboratory Homogenizer

Posted by David Shechter on Mar 26, 2018 2:10:06 PM

Top view of businessman legs choosing his way-747702-edited.jpegMost of us have experienced the activity (or drudgery) of purchasing an automobile, and the process of selecting one can be extremely tedious. There are a wide array of manufacturers, models, colors and sizes from which to choose and even more options within those choices.

Fortunately, selecting a laboratory homogenizer that best meets your business needs doesn’t have to be as complicated. If you purchase a model that accommodates your required applications, it should be able to serve your homogenization needs for the long-term. Even though all laboratory homogenizers can accomplish emulsions, cell disruptions and more, understanding the commercially available homogenizing methods can make it simpler to determine the right homogenizer for a particular application.

Main Methods of Homogenization

The primary homogenization methods include ultrasonic, mechanical and high-pressure. Ultrasonic homogenizers, or sonicators, are used in cell lysis and particle size reduction applications. They are best utilized for samples which are incredibly difficult to disrupt, including tough animal tissues, spores, soil samples and liposomes. Although they are often used to process small samples in suspension and do not require pre-grinding or cutting, ultrasonic homogenizers generate heat, which can harm temperature-sensitive samples.

Mechanical homogenizers work by using pressure (shearing) and/or force to disrupt cells. They produce consistent results quickly and are able to alter a sample’s physical structure while maintaining its chemical composition. The mechanical homogenization method provides for easy scalability and especially well-suited for animal tissues and cells.

Probably the most commonly utilized method, high-pressure homogenizers have the capability to lyse cells and create emulsions, thereby enabling a longer product shelf life and an even distribution of active ingredients. They are one of the most efficient fluid processing systems for cell disruption and particle size reduction, especially for applications which require minimum particle sizes and homogenous mixtures. High-pressure homogenizers enable the study of tissues, cells and more.

Factors to consider when choosing a brand and model of laboratory homogenizer include:

  • Sample types.
  • Maximum operating pressure. 
  • Mixing speed. 
  • Processing setup. 
  • Processing range.  

Benefits of BEE International

At BEE International, our laboratory high-pressure homogenizers were designed to provide formulation scientists with more experimentation options and capabilities for emulsions, dispersions, cell rupture and liposomes. Plus, they offer a multitude of benefits and features, such as operating pressures of up to 45,000psi/3,100bar, 100 percent guaranteed scalability of results, lifetime training for new employees and students, CE and cGMP compliance and a one-year factory warranty.

Following is a list of the laboratory homogenizers we offer:

  • Nano DeBEE Laboratory Homogenizer - The smallest in our line of laboratory homogenizers, this cost-effective benchtop unit offers a reliable and consistent process for virtually any laboratory setting. With features including a state-of-the art reservoir for small volumes, an adjustable process pressure gauge, a heat exchanger and a back- pressure gauge, this is a popular choice for an entry-level laboratory homogenizer.
  • Micro DeBEE Laboratory Homogenizer – This air-operated, compact, benchtop unit is suitable for a broad range of applications, including cell disruption, particle size reduction, work with polymers and liposomes and the creation of nano and micro emulsions and dispersions. This model offers a bit more capacity and power than the Nano DeBEE Laboratory Homogenizer.
  • Mini DeBEE Laboratory Homogenizer - This cost-effective unit is suitable for both laboratory and research and development work as well as pilot plant and industrial production. It offers the same features as the Nano and Micro DeBEE Laboratory Homogenizers but with added capacity and power. Other features of this model include pressures up to 45,000 psi, 100 percent guaranteed scalability of results and a programmable logic controller a digital display.

Please contact us today to learn more about our laboratory homogenizers or any other homogenizers in our product line. No matter which model you select, they all meet our high standard of quality and offer features easily configured to meet your application needs and processing goals. 

For more information on cell lysis and the multiple methods that could be what your application needs, download our FREE eBook:

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