3 Benefits of Efficient Particle Size Reduction

Posted by David Shechter on Feb 24, 2017 12:30:00 PM

benefits_efficient_particle_reduction.jpgParticle size reduction is a powerful technique that is used in a number of growing manufacturing industries, including pharmaceutical, cosmetic, and biotech. With benefits including a longer shelf life of final product, as well as improved taste, texture, and appearance, it’s no wonder that more and more industries are looking to utilize this incredible process step. However, when choosing the right homogenizer for the job, it is important to understand some of the benefits of efficient particle size reduction. Being armed with this information is the first step in ensuring you are choosing the right equipment for your end goal. Continue reading to learn more about three benefits of efficient particle size reduction.

Higher Quality Products

In countless industries, reduced particle size has significant benefits to manufactured materials. In the chemical industry, for example, reduced particle size allows for smoother surface quality, increased conductivity, increased particle coating during formulations, higher particle packing, and overall increases in high quality product function. These benefits can be seen in a number of finished goods, including adhesives, pigments, ink dispersions, pastes, resin additives, and polymers.

Numerous Health Benefits

In addition to increased quality, efficient particle size reduction not only reflects well on food manufacturers, for instance, but can also result in a number of health benefits to the end consumer. Food that is comprised of smaller particles can result in increased growth in children and teens, as well as decreased overall food intake as a result of satiety.

Increased Bioavailability of Drugs

Finally, efficient particle size reduction can increase the bioavailability – that is, the fraction of an active drug ingredient that gets absorbed into the body – of pharmaceutical drugs. A product’s bioavailability has a direct correlation with efficacy; smaller, consistent particle sizes have increased oral bioavailability, and are thus able to achieve their desired function more effectively. Smaller particles are also more readily dissolved into a solution, thanks to their larger surface areas.

BEE International: High Quality Particle Size Reduction Equipment

No matter what your industry calls for, you can rest assured that BEE International has the right homogenizing equipment for the job. With a number of homogenizers suitable for a variety of settings, including laboratories, research and development labs, pilot plants, and industrial manufacturing zones, we have the right homogenizers for your industry. To learn more about the suite of homogenizers BEE International has to offer, please contact us today. We would love to help you on your journey to efficient particle size reduction.

Download our FREE eBook for even more information on how to achieve efficient and consistent particle size reduction:

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How the DeBEE 4000 Can Benefit Manufacturing Industries

Posted by Deb Shechter on Feb 23, 2017 12:30:00 PM

debee_4000_manufacturing_industries.jpgMore and more, common industries — cosmetic, food, pharmaceutical, and biotech, to name a few — are utilizing homogenization equipment to improve their processes. With benefits including improved product texture, taste, and quality, as well as reduced manufacturing costs, its no wonder that more and more industries are looking to get involved in the powerful homogenization process. However, when searching for the right homogenizer to suit your needs, the options are bountiful. We are here to help! Continue reading to learn more about just one of our powerful homogenizers — the DeBEE 4000 — and the many ways it can benefit the manufacturing industry.

Proprietary Homogenizing Technology

The DeBEE 4000 is just one of many homogenizers that we offer at BEE International; however, it represents our top of the line series. It offers the highest level of automation and process controls, as well as the ability to integrate with plant controls network. In addition, the DeBEE 4000 offers state of the art homogenizing technology in the form of computerized controls as well as repeatable and scalable results.

At the core of our proprietary homogenizing technology is our patented advanced intensifier pumping systems, which allow for constant pressure with electronic synchronization, numerous available cylinder sizes to match specific pressure, flow capacity, and product characteristics requirements, and a unique Clean in Place (CIP) position, which allows flow to move through the high pressure cylinder for faster and more thorough cleaning.

Multiple Process Affecting Forces

The DeBEE 4000 also takes advantage of not just one, but many forces that affect the process. These multiple forces allow for the most advanced results in processing equipment, especially where elevated requirements must be met. Our technology combines the processes of turbulent premixing, cavitation, impact, shear, and intensity. These forces combined allow for improved results in fewer passes. It also means that the results achieved through are equipment are repeatable, reliable, and scalable — all the way up to the manufacturing level.

Other Benefits of the DeBEE 4000

The benefits of the DeBEE 4000 are virtually endless, and include the following:

    • Proprietary synchronized pumping system for a constant process
    • Hydraulically driven vertical intensifier pumps with a low stroke rate
    • Higher pressure capability and process intensity
    • Low maintenance cost
    • Redundant intensifier option
    • Dynamic visual schematics indicating system parameters and component status
    • SCADA and cGMP compliance

To learn more about our DeBEE 4000, as well as the other homogenizing equipment that BEE International offers, please contact us today.

For more information on cell lysis methods and how to choose the right one, download our FREE eBook:

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High Pressure Homogenizers: How They Help with Chemical Applications

Posted by Deb Shechter on Feb 22, 2017 7:30:00 AM

homogenizers for chemical applications.jpgHigh pressure homogenizers are gaining in popularity among a number of growing industries, including pharmaceutical, biotech, chemical, food, and cosmetic. The benefits of this powerful technology are many. However, before purchasing your next high pressure homogenizers, it may be useful to understand more about how this equipment can help with chemical applications. Continue reading to learn more about how high pressure homogenizers help with chemical applications, as well as more information about the homogenizers that BEE International offers in our ever-growing suite of products.

Processing Setups to Address Unique Challenges

High pressure homogenizers are often used to reduce particle sizes of materials in order to create more stable emulsions and dispersions. Furthermore, our technology offers unique processing set-ups to address specific processing challenges. For example, our dual feed technology involves the use of a secondary downstream port, which allows for even the most abrasive and viscous of materials to be processes. Dual Jets allow for multiplication of the impact for size reduction of very hard materials. Finally, our equipment offers high viscosity chemical process equipment solutions, which allows for formulation and dispersion of final products in a single step.

Size Reduction of Challenging Materials: Benefits

High pressure homogenization equipment allows industries to scale up existing processes, perform ongoing pilot production work, and even reduce manufacturing costs through optimization. Other benefits of size reduction of challenging materials includes the ability to not only create new and unusual particle morphologies, but to preserve those particle morphologies. In addition, our one-step blending and formulation process allows for an accelerated chemical process that reduces costs while further optimizing the manufacturing process.

Ideal Dispersions and Finer Particles: Benefits

A high quality high pressure homogenizer allows for high quality emulsions and dispersions to be created. This opens the door to a number of benefits, including maximum particle packing, increase in dense cross sections of final products, better particle coating during formulations, smoother surface quality, finer printed features, and an increase in conductivity.

Products that Benefits from High Pressure Homogenizing Equipment

There are a number of products that stand to benefit from our high pressure homogenizer chemical process equipment. These products include, but are not limited to polymers, acrylic emulsions, urethane prepolymers, solvent-based emulsions, pigment and ink dispersions, carbon nanotubes, additives and resins, and adhesives and pastes.

To learn more about high pressure homogenization, as well as how our equipment at BEE International can help with your processing needs, please contact us today.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Pilot and Industrial Homogenizers: Which One Should You Choose?

Posted by David Shechter on Feb 20, 2017 12:30:00 PM

Pilot and Industrial HomogenizersRegardless of the industry you are in, there is a high likelihood that you have either used homogenization equipment or are planning to in the near future. With industries such as cosmetic, food, pharmaceutical, and biotech all utilizing the process of homogenization in one form or another, you’ll be hard pressed to find an industry that doesn’t use this innovative and groundbreaking technology.

But before you select the right homogenizer for the job, it is important to know more about the options that are out there. At BEE International, we have a number of homogenizers to meet virtually every need in just about every industry. And while our selection of laboratory homogenizers work well for a smaller lab or research & development setting, for larger scale purposes, it makes sense to choose a larger, more robust homogenizer for the job. Continue reading to learn more about the pilot plant and industrial homogenizers that BEE International has to offer.

DeBEE 2000 Pilot Plant Homogenizer: The Ultimate Development Tool

The DeBEE 2000 is our smallest unit available at BEE International that still offers the wide functionality you would expect to find in a pilot plant homogenizer. It offers a number of powerful options, including dual feed, dual jet, and automatic CIP (Clean In Place). Other features include:

  • Variable operating pressure from 5,000 – 45,000psi
  • Modular design for lower cost replacement parts
  • PLC control and monitoring for simple operation
  • Various process configurations including control of cavitation, shear, and impact
  • Adjustable back pressure
  • Heat exchanger for product cooling

DeBEE 3000 Industrial Homogenizer: Cost Effective Production System

The DeBEE 3000 is larger than the DeBEE 2000, and is perfect for industrial use. It can be used to both scale up a process or upgrade an existing one, and can be configured in numerous ways to meet your unique production needs. Other features include:

  • Particle size reduction capabilities for micro and nano emulsions and dispersions
  • Hydraulically driven vertical intensifier pumps
  • Automatic pressure control and alarm management
  • Data trending and storage
  • CFR 21 part 11 compliant

DeBEE 4000 Automated Industrial Homogenizer: Highest Level of Automation and Production Capacity

The DeBEE 4000 rests comfortably at the top of our line of offerings, and offers the highest levels of process control and automation. This versatile homogenizer is suitable for a number of applications, including the creation of injectable drugs and chemical slurries. Other features of this powerful homogenizer include:

  • Security modes and authorizations
  • Programming maintenance schedules into the system
  • SCADA compliance
  • Trends screen
  • Sanitary design and features

No matter which pilot or industrial homogenizer you choose, you can rest assured that you are purchasing the best quality homogenizer that money can buy. To learn more about our unique offering of homogenizers, please contact us today.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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High Pressure Homogenization for the Biotechnology Industry

Posted by David Shechter on Feb 17, 2017 12:30:00 PM

homogenizers-for-biotechnologyHomogenization, also known as particle size reduction, has countless benefits for a number of industries, including pharmaceutical, cosmetic, food, and fuel. However, the biotechnology industry also has a use for the powerful technology that homogenizing equipment offers.  The synthesis of biofuels, medicine, and vaccinations are just a few things that this growing field is responsible for, and high pressure homogenization allows these critical processes to take place. Continue reading to learn more about high-pressure homogenization in the biotechnology industry, as well as more information on how BEE International can help your industry meet its manufacturing goals.

Applications of Homogenizers in the Biotech Industry

High pressure homogenizers allow for many processes to take place within the biotech industry, including cell disruption, particle size reduction, micro and nano emulsions and dispersions, and much more.  

In the case of cell disruption, homogenizers allow for a variety of cells – E. coli, yeast, bacteria, and even delicate animal tissues – to be ruptured in order to recover the contents of essential cells.

High pressure homogenizers can also be utilized to create cost effective medicines, modify microorganisms, synthesize new chemicals, and develop alternative biofuels.

Advantages of High Pressure Homogenization for Biotechnology

High pressure homogenizing equipment offers a number of benefits in the world of biotechnology. Here are just a few of the benefits:

  • Ability to gain access to intracellular contents for a variety of cells
  • User autonomy to alter pressure, process intensity, cavitation, shear, and turbulence
  • Higher protein recovery, thanks to the use of pressure (instead of heat)
  • Scalability to account for increased demand and/or sample size

High Pressure Homogenizers from BEE International

BEE stands for Best Emulsifying Equipment, and we stay true to that promise. Our line of high pressure homogenizing equipment is suitable for virtually every industry, and can work in just about any environment – from small scale research and development laboratories all the way up to pilot plants and industrial plants.  The results gained from our equipment are high quality and repeatable, and offer guaranteed scalability. Other benefits of our equipment include:

  • CE and cGMP compliant
  • Maximum pressure of up to 45,000 psi (3,100 bar)
  • Menu guided maintenance and calibration
  • Synchronized pump system for constant pressure
  • Pharma/Bio/Food sanitary
  • Multiple process intensifiers
  • Password protected operation
  • Capacity of up to 480 LPH
  • Complete automation, compliance, and production capacity

To learn more about our suite of high pressure homogenizers, please contact us today.

For more information on high pressure homogenizers and cell lysis methods, download our FREE eBook:

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3 Major Benefits of Homogenizers in the Food Industry

Posted by Tal Shechter on Feb 15, 2017 12:30:00 AM

homogenizers in the food industryHomogenization, also known as micronization or, more simply, particle size reduction, is a process that is growing in popularity in a number of manufacturing industries, including cosmetic, chemical, biotech, and pharmaceutical. However, few people realize that the process of homogenization is utilized in another industry, one that affects virtually all of us – food! The use of homogenization equipment in the food industry offers a number of benefits, both to the industry itself, and to the customers, who receive the end results of the industry. Continue reading to learn more about the many benefits that homogenizers bring to the important (and ever growing!) food industry.

1. Extension of Shelf Life

One little known benefit that homogenization offers is an improved shelf life.  The process of reducing particle sizes requires the use of intense pressure, among other forces. This pressure that is exerted on food products often results in the creation of more stable chemical structures. This results in increased freshness, as well as a longer shelf life of the end product.

2. Improved Quality of Food

The process of homogenization also results in a higher quality of food. The reduction of particle size of products results in an end product that has improved taste, texture, appearance, and overall quality over its non-homogenized counterparts.

3. Food Preservation 

Related to the extension of shelf life benefit that homogenization brings is the benefit of food preservation. While heat treatment – another method of preserving food – is effective in killing harmful bacteria and microorganisms, heat can also kill helpful microorganisms, vitamins, and nutrients. Homogenization, on the other hand, uses pressure to accomplish the same task as its more destructive counterpart. This results in food that is preserved and healthy. A win-win!

BEE International Homogenizers

Homogenization offers many benefits to those in the food industry, as we now know. When searching for the right homogenizer for the job, make BEE International your first stop. We offer homogenizers for virtually every environment and application, including laboratory use, research and development applications, and, of course – pilot plant and industrial operations.  In addition, our homogenizers offer some of the following benefits:

  • Constant pressure with electronic synchronization
  • Unique CIP (Clean in Place) positioning for thorough cleaning
  • Numerous cylinder sizes available to match specific pressure, flow capacity, and product characteristics requirements

To learn more about the homogenizers offered at BEE International, as well as how we can help with the homogenization process in your industry, please contact us today.

For more information on particle size reduction and how to get efficient and consistent results, download our FREE eBook:

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How Homogenizing Cell Technology Works

Posted by Tal Shechter on Feb 13, 2017 12:30:00 PM

Homogenization, also known as micronization or particle size reduction, is an important processing step in a number of growing industries, including pharmaceutical, biotech, cosmetic, and food. This critical processing step allows for active ingredients to assimilate more readily into a number of given mediums – creams or sauces, for example – to create an ideal texture, taste, and appearance. With benefits including increased product quality, improved customer satisfaction, and lower overall cost, it’s no wonder that more and more industries are seeking to implement the process of particle size reduction in their manufacturing process.

Regardless of your industry, if you are on the market for a new piece of homogenizing equipment, BEE International has a variety of homogenizers to meet the needs of your unique industry. But before choosing the right homogenizer for the job, it is important to understand the technology behind our powerful homogenizing equipment.  For us at BEE International, that technology begins with our powerful homogenizing cell technology. Continue reading to learn more about this powerful technology and how it helps our homogenizers soar to the top of their class.homogenization cell technology

BEE Emulsifying Cell

At the heart of the homogenizing technology at BEE International, our patented EC – or emulsifying cell – can be found. This EC is a powerful tool, equipped with a number of unique and customizable options. The EC utilizes a number of mechanical forces, including shear, cavitation, and impact, to optimize new and improved products in the world of manufacturing. The EC is a modular device that can be setup easily to allow for a number of different process effects.

BEE Process Flow Setups

Another powerful feature of our Emulsifying Cell is boundless customization. Along with the ability to control pressure, cavitation, impact, and shear, the process flow can also be controlled in any manner that you prefer.  This allows for guaranteed scale up from a laboratory setting to full blown manufacturing.

With a parallel flow setup, the product flows in one direction and exits from the opposite end of the nozzle of the emulsifying cell. In a reverse flow setup, the product is forced to flow back towards the nozzle, which creates an annular stream around the incoming jet stream, allowing for high shear. Finally, with a dual jet setup, two product inlets are used with two nozzles to create two jets of product, allowing for the most intense process.

We at BEE International pride ourselves on offering homogenizing equipment with the most customization on the market to allow for the best overall customer experience. To learn even more about our technology and line of homogenizers, please contact us today.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Laboratory vs. Industrial Homogenizers: Which One is Best for You?

Posted by David Shechter on Feb 10, 2017 12:30:00 PM

laboratory vs industrial homogenizersHomogenization is defined as the process of reducing particle size. This process is utilized in a number of industries, including pharmaceutical, cosmetic, biotech, and food. With benefits including increased shelf life, increased taste, texture, and visual appearance, and lower overall cost, it’s no wonder that more and more industries are on the market for a homogenizer that can optimize their process.

However, with so many homogenizers to choose from, it can be hard to narrow down the right processing equipment for your industry. BEE International offers a number of laboratory, pilot, and industrial homogenizers, but which one is right for your industry’s needs? Continue reading to learn more about the homogenizers that BEE International offers.

Laboratory Homogenizers

BEE International offers a number of laboratory homogenizers that not only suit the needs of virtually every industry, but fit in practically every environment as well. Our laboratory homogenizers are well suited for chemical and pharmaceutical processing and manufacture, as well as research, development, and scale up. The laboratory homogenizers that BEE International offers include the Nano DeBEE, Micro DeBEE, and Mini DeBEE. These homogenizers offer the following features and benefits:

  • Maximum operating pressures of up to 45,000 psi (3,100 bar)
  • Capacity of up to 400 mL/min and 22 L/hr
  • Experimentation options and capabilities for emulsions, dispersions, and cell rupture
  • Equipped with spare parts and tools for easy repair
  • Results that are reliable, repeatable, and scalable to manufacturing

Pilot and Industrial Homogenizers

While our laboratory homogenizers offer a wide variety of features for use in research & development or laboratory settings, our pilot and industrial homogenizers take convenience and reliability to a whole new level, offering a great deal of control over all fundamental process parameters, ensuring the highest quality finished product. In addition, each of our pilot and industrial homogenizers feature our patented emulsifying cell, which offers a linear process that ensures scalability of results. The pilot and industrial homogenizers that BEE International offers include the DeBEE 2000, DeBEE 3000, and DeBEE 4000. These homogenizers offer the following features and benefits:

  • Constant pressure with electronic synchronization
  • Numerous cylinder sizes available
  • Unique Clean in Place (CIP) position, allowing for faster and more thorough cleaning
  • Adjustable settings for pressure, flow capacity, and product characteristics

To learn more about the homogenizers offered by BEE International, please contact us today.

For more information about particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Chemical Processing Equipment: How High Pressure Homogenizers Work

Posted by Deb Shechter on Feb 9, 2017 12:30:00 PM

chemical processing equipmentHomogenization is defined as the reduction of particle sizes. This process can be accomplished several different ways, through mechanical, manual, or chemical means. And while high pressure homogenization is quickly gaining popularity in the fields of biotech, pharmaceutical, cosmetic, and food, it is in the chemical field that the use of high pressure homogenizers is quickly gaining ground over other techniques of particle size reduction.

The use of chemical processing equipment, such as high pressure homogenizers, allows manufacturers in the chemical industry to improve a wide range of materials by creating more diverse reactions. But what other benefits and features do high pressure homogenizers bring to the table? Continue reading to learn more about the unique benefits and features that BEE International’s line of homogenizers bring to the ever-growing chemical industry.

BEE International offers a number of high pressure homogenizers that are suitable for virtually any application in the chemical industry. Our Nano DeBEE, Micro DeBEE, and Mini DeBEE homogenizers are excellent for a laboratory or research and development setting, while the larger DeBEE 2000, DeBee 3000, and DeBEE 4000 work well in pilot plant and industrial settings. No matter which homogenizer you choose, you can rest assured that the unique processing setups offered with our technology can address any number of processing challenges.

Benefits of BEE International High Pressure Homogenizers

In addition to having the ability to create consistent emulsions and dispersions, the technology utilized in our homogenizers allows for even the most challenging of processes to be readily handled. Our dual feed allows for the addition of abrasive and viscous materials, while our dual jets allow for even the hardest of materials to be reduced in size. Finally, our high viscosity chemical process equipment solutions means that final products can be formulated and dispersed in a single step.

Other benefits offered by our high pressure homogenizers include:

  • Size reduction of challenging materials
  • Preservation of existing particle morphologies
  • Densification
  • Purification
  • One-step blending and formulation
  • Increase in dense cross section of final products
  • Increase in conductivity
  • Smoother surface quality
  • Ability to process polymers, pigment and ink dispersions, carbon nanotubes, additives, resins, adhesives, and pastes

To learn more about our high quality, high pressure homogenizing equipment, as well as to receive more information on how our chemical processing equipment can help with the unique needs of your industry, please contact us today.

For more information on cell lysis and how to choose the right method, download our FREE eBook:

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How Homogenizers Benefit the Pharmaceutical Manufacturing Process

Posted by David Shechter on Feb 6, 2017 12:30:00 PM

How Homogenizers Benefit the Pharmaceutical Manufacturing Process.jpgHomogenization, the process of reducing particle size, is gaining popularity in the pharmaceutical field, where its benefits can be realized in the research and development of new medicines, drugs, and treatments. But how exactly do high pressure homogenizers benefit the pharmaceutical manufacturing process? And what advantages do BEE International homogenizers over equipment offered by competitors? Continue reading for more information on the many ways homogenization, and our homogenizing equipment, can benefit those in the pharmaceutical industry.

Effective Particle Size Reduction

BEE International offers a number of homogenizers that are well suited for use in the pharmaceutical industry, including the Micro DeBEE, Nano DeBEE, and Mini DeBEE. These homogenizers effectively use multiple mechanical forces – turbulence, cavitation, shear, and impact – to achieve the best results. These forces, used in combination, allow for effective particle size reduction in fewer passes, resulting in increased product efficiency and quality.

Effective Cell Disruption and Cell Lysis

Not only are our homogenizers highly effective at reducing particle size, they are also well suited for effective, yet gentle, rupturing of cells. Our homogenizers are capable of lysing virtually any type of cell, including yeast, bacteria, algae, fungi, E. coli, and even delicate mammalian tissue.

Repeatable, Adjustable, and Scalable Results

BEE International’s line of high pressure homogenizers offer the highest quality available in today’s market. Our equipment offers a host of features, including a maximum operating pressure of up to 45,000 psi, capacities of up to 400 mL/min, and parallel, reverse, and dual feed process settings. In addition, the mechanical forces offered by our homogenizers can be adjusted and fine-tuned to meet the unique needs of the pharmaceutical industry. This allows for results that are not only high quality, but repeatable, adjustable, and scalable as well.

Unparalleled Customer Support

Your relationship with BEE International does not simply end after you purchase one of our high pressure homogenizers. Our equipment carries an extensive warranty, which covers any damage to the machine (not caused by the customer) 100%. In addition, BEE International provides extensive training and installation support, with additional support available over the phone as needed. We stand behind our product, and our customer’s satisfaction is of the utmost importance to us.

For more information on our homogenizing equipment and how it can increase the quality of your pharmaceutical products, please contact us today. To learn more about how BEE International’s high pressure homogenizers can benefit the pharmaceutical process, download our free eBook here:

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