Choosing the Right Laboratory Homogenizer

Posted by David Shechter on Apr 27, 2017 12:30:00 PM

laboratory homogenizerHomogenization, defined as micronization, or more simply put, particle size reduction, plays an important role in a number of industries, including pharmaceutical, biotech, cosmetic, and even food. The next time you apply anti-aging cream or moisturizer, drink an ice-cold and creamy glass of milk, or take a prescription painkiller, you can thank the powers of homogenization! With the wide variety of uses, it’s no wonder that more and more industries are looking to purchase a homogenizer of their own. But before jumping into a purchase, it is important to learn more about your options. BEE International is here to help. Continue reading to learn about the selection of laboratory homogenizers that we have to offer.

Nano DeBEE Laboratory Homogenizer

Our Nano DeBEE Laboratory Homogenizer is our smallest in our line of laboratory homogenizers, but even within this small piece of equipment, you can rest assured that it is capable of a lot. This cost effective bench top unit offers a reliable and consistent process for virtually any laboratory setting. With features including a state of the art reservoir for small volumes, an adjustable process pressure gauge, a heat exchanger, and even a back pressure gauge, it is easy to see why this is a popular choice for an entry level laboratory homogenizer.

Micro DeBEE Laboratory Homogenizer

Our Micro DeBEE Laboratory Homogenizer is an air-operated, compact, bench top unit that is suitable for a broad range of applications, including cell disruption, particle size reduction, work with polymers and liposomes, and the creation of nano emulsions, micro emulsions, nano dispersions, and micro dispersions. If you are looking for a piece of equipment that offers a bit more capacity and power than the Nano DeBEE Laboratory Homogenizer, this is the right choice.

Mini DeBEE Laboratory Homogenizer

Last, but certainly not least, is our Mini DeBEE Laboratory Homogenizer. This cost effective unit is suitable for both laboratory and R&D work, as well as pilot plant and industrial production. It offers the same features as the Nano and Micro DeBEE Laboratory Homogenizers with a lot more capacity and power. Other features include pressures up to 45,000 psi, 100% guaranteed scalability of results, PLC control with a digital display, and a 1-year factory warranty.

The world of laboratory homogenizers is vast, but that doesn’t mean it has to be complicated! All our our purchases come equipped with a robust 1-year warranty, as well as lifetime training for new employees and students. We would love to work with you on your next big project — contact us today for more information on these homogenizers, as well as other products in our wide line of homogenizers.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Choosing the Right Pilot & Industrial Homogenizer

Posted by Tal Shechter on Apr 18, 2017 12:30:00 PM

choosing right pilot and industrial homogenizerHomogenization, also known as particle size reduction or micronization, is a technique that is widely used across a number of industries: cosmetic, food, pharmaceutical, and biotech. This powerful (and useful) technique allows manufacturers to create uniform creams, visually pleasing sauces, and effective pharmaceutical painkillers, just to name a few applications. And without the innovative technology found within homogenizers,  few of the aforementioned products would be as readily available as we’ve come to expect.

With that, it is no surprise that the task of choosing the right homogenizer for the job is an often daunting task. With so many options on the market to choose from, it is easy to get overwhelmed. However, if certain key points are kept in mind, choosing the right homogenizer for your pilot or industrial plant can be simple. Continue reading to learn more about the pilot and industrial homogenizers offered by BEE International.

DeBEE 2000 Pilot Plant Homogenizers

The DeBEE 2000 line of homogenizers represent the smallest available units that offer all available process configurations, including dual feed, dual jet, and automatic clean in place (CIP) technology.  These homogenizers also offer a number of powerful validation packages, as well as hazardous environment protection, feed solutions, and additional process monitoring.

DeBEE 3000 Industrial Homogenizers

The DeBEE 3000 line of homogenizers are our entry level production scale models, suitable for both laboratory work as well as scaled up production work. No matter the needs of your industry, the DeBEE 3000 line of homogenizers are suitable for your process. These homogenizers offer unmatched particle size reduction with maximum efficiency for micro/nano emulsions and particles, as well as the highest yield in cell rupture in the shortest amount of time.

DeBEE 4000 Automated Industrial Homogenizers

The DeBEE 4000 line of homogenizers represent the most powerful line of homogenization equipment that BEE International has to offer. This series of equipment offers the highest levels of process controls and automation, as well as integration with plant controls and compliance with CFR 21 part 11 requirements. In addition to other powerful benefits, these homogenizers offer various security modes and authorizations, alarms to ensure system safety and the correct course of action, SCADA compliance, and sanitary design and features suitable for even the most stringent of fields.

To learn more about the line of homogenizers offered by BEE International, please contact us today. We look forward to working with you on your next homogenization project.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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3 Key Features of Intensifier Pumping Systems

Posted by David Shechter on Apr 12, 2017 12:30:00 PM

intensifier pumping systemsHomogenization, or particle size reduction, is, as the name suggests, the process of decreasing the size of particles. This popular technique is used in numerous industries for the manufacture of a wide variety of products, from pharmaceutical painkillers to anti-aging cream, and just about everything in between. But in order for homogenizers to do their job, the right technology is necessary. One such technology, one that is at the heart of our homogenizers, is Intensifier Pumping Systems.

We at BEE International have our own proprietary pumping system, designed for heavy duty, leak free, and long life cycle operation. This rugged system is designed for use in a wide variety of industries, including cosmetic, biotech, and even food. Our pumping system is made up of intensifiers that are actuated and synchronized by PLC – Programmable Logic Controller – to deliver constant pressure and flow through the homogenizing cell. Continue reading to learn more about our intensifier pumping system, as well as three key features that makes this technology the top of its class.

High Pressure Cylinder

The high pressure cylinder, also known as the HP cylinder, takes in product that flows from the system inlet port. During the suction stroke of the pump, it enters the HP cylinder, where it is then pushed out to the emulsifying cell (EC) during the power stroke of the pump.

Isolator

The isolator piece holds the hydraulic cylinder and the high pressure (HP) cylinder together, all while preventing cross contamination between the product fluid and hydraulic fluid.

Hydraulic Cylinder

Finally, the hydraulic cylinder, which is powered by the hydraulic power unit, takes in pressurized oil and pushes the hydraulic piston, which causes the piston to reciprocate.

These three sections of the intensifier pumping system work together to optimize the homogenization process, allowing for a process that is reliable, repeatable, and produces high-quality results. Other benefits of this technology include the following:

  • 5 different hydraulic cylinder sizes
  • 3 different high pressure cylinder sizes
  • Operating pressures of up to 45,000psi
  • Advanced intensifier controls allow for automation at the push of a button
  • Variable operating speeds to allow for the optimization of the process based on requirements
  • Ability to handle highly viscous materials
  • Long service life
  • Clean in Place (CIP) technology

To learn more about our proprietary intensifier pumping system, as well as more information on our wide variety of homogenizers, please contact us today. To learn more about the technology used here at BEE International, click here.

For more information homogenization and how to choose the right cell lysis method, download our FREE eBook:

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Small Particle Sizes: 3 Key Benefits

Posted by David Shechter on Apr 5, 2017 11:30:00 AM

small particle sizef you work in the fields of biotechnology, cosmetics, pharmaceuticals, drugs, or food, chances are you have a good idea of what homogenization is. And if that term sounds foreign to you, you may be wondering what the big deal is about homogenization. No matter which of the two categories you fall into, this article will provide useful information to gain more knowledge and insight into this powerful process.

So what is homogenization, exactly? The definition is quite simple: homogenization is the process of reducing the particle size of a product. Whether you are creating pain relieving pills, anti-aging moisturizing cream, or a cold glass of milk, homogenization plays a powerful role in the manufacture of the components that make up these, as well as many other finished goods. While the reduction of particle size may seem like an action with limited benefits, that is just not the case. Continue reading to learn more about the key benefits of small particle sizes.

Greater Product Stability

When manufacturers achieve a tight distribution of particles – a byproduct of successful homogenization – the benefits are endless. A tight distribution of particles allows for greater product stability, which then allows for a longer shelf life, optimized particle characteristics, uniform temperature and reactive qualities, and higher overall product quality. This, in turn, leads to increased sales and increased customer satisfaction.

Manufacturing Efficiency

Small particle sizes also allow manufacturers to build a process that is cost effective and efficient, due to the fact that fewer passes need to occur. In a world of tight budgets and a growing desire for proven ROI within corporations, any and all efficiencies within the manufacturing process are welcomed and desired.

Consistent Results

Finally, reduced particle sizes of particles that comprise finished goods allows manufacturers to achieve consistent, precisely controlled, and repeatable results. The importance of consistent results is far-reaching; consistent results allow processes to be scaled up from a smaller laboratory setting to pilot plant production and even full-scale industrial operations.

BEE International: Homogenizers that provide quality results

If quality results are what you’re looking for, look no further! Our line of homogenizers at BEE International possess all of the features you are looking for at a price that will certainly fall within your budget. By utilizing the powerful forces of turbulence, cavitation, shear, and impact, our homogenizers guarantee results that are repeatable, scalable, and are the highest of quality. To learn more about our homogenizing equipment, please contact us today. We look forward to working with you on your next large project.

For more information on how to achieve efficient and consistent particle size reduction, download our FREE eBook: 

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Methods of Liquid Homogenization

Posted by David Shechter on Apr 3, 2017 12:30:00 PM

liquid homogenization methodsHomogenization, or particle size reduction, takes place when particles, molecules, tissues, or other materials are reduced in size. This unique process offers a number of benefits, including more even particle distribution through products like creams, sauces, and medications; it also offers the additional benefit of improved texture, appearance, and taste, which leads to higher customer satisfaction and sales. With all of these benefits, it’s no wonder that more and more industries are looking to get involved with this process!

This article will explore the various liquid homogenization methods. Continue reading to learn more about the three most common types of liquid homogenizers: the French Press, the Potter-Elvehjem Homogenizer, and the Dounce Homogenizer.

French Press

The French Press is most often used for small sample volumes -- usually samples that are 250mL or less. In this method, a piston is used to apply high pressure to the sample, which forces it through a small hole, which homogenizes the product. While the French Press is efficient in homogenizing, since it is suitable for small samples only, the throughput is quite low.

Potter-Elvehjem Homogenizer

The Potter-Elvehjem Homogenizer is often used with delicate tissues, where the end desire is a ruptured cell wall (and not destroyed tissues!). This homogenizing equipment works in one of two ways: mechanically or manually. In both cases, a pestle is forced into a round shaped vessel to homogenize the cells. This homogenizer is not as efficient as a French Press, but is often more affordable.

Dounce Homogenizer

The Dounce Homogenizer is similar to the Potter-Elvehjem Homogenizer, in that a pestle is used to manually force cells through a small tube. The materials of a Dounce Homogenizer are often made of glass, which results in equipment that is easily sterilized and cleaned. However, like both the French Press and Potter-Elvejem Homogenizers, the Dounce Homogenizer is best suited for small samples, since the throughput is so low.

BEE High Pressure Homogenizers

BEE International offers a number of high quality, high-pressure homogenizers. Unlike the other homogenizers mentioned, our homogenizers are suited for large samples, and offer large throughputs, making our equipment ideal for laboratory, pilot plant, and even industrial use. Our equipment utilizes multiple forces – shear, turbulence, impact, and cavitation – to allow for results that are reliable, repeatable, and high quality.

We at BEE International would love to assist you on your next project. Please contact us today to learn more about our equipment and how we can help you enter the growing world of homogenization.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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3 Products that Benefit from Homogenization

Posted by Deb Shechter on Mar 31, 2017 12:30:00 PM

Number 3 in 3D isolated over a white background-248466-edited.jpegHomogenization, also known as micronization or particle size reduction, is the process of forcing materials through a small orifice to disrupt, lyse, or otherwise reduce the size of the particles within that material. And as those in the cosmetic, pharmaceutical, biotech, and food industries know, homogenization is a powerful process tool with countless benefits, including reduced costs, higher quality, increase customer satisfaction, and time savings. But what types of products can benefit from homogenization? The answer may surprise you. Continue reading to learn more about the products that reap huge benefits from the innovative process of homogenization.

Beverages

Beverages can reap huge benefits from the processes of both homogenization and pasteurization. These processes often work hand in hand, and result in beverages that are full of nutrients, safe to consume, and visually appealing. Homogenization and pasteurization work together to limit the growth of harmful pathogens, maintain flavor and nutrients, and can even improve the shelf life of the end product.

Pharmaceutical Drugs

The process of homogenization allows for the highest quality pharmaceutical drugs to be produced safely, reliably, and inexpensively. Particles that have had their sizes reduced through homogenization enjoy increased dissolution rates, which allows for improved drug delivery (especially via nasal or oral introduction), more even dispersion of critical active ingredients, higher safety and quality overall.

Cosmetic Creams

Cosmetic creams and lotions can also benefit from the process of homogenization. Most creams are emulsion-based, and homogenization allows these emulsions to be created more quickly, safely, and reliably than other methods.  Homogenization also frees up the possibility of using water as both a diluent and a solvent, since the smaller particles created within the emulsion dissolve rapidly and completely in virtually every medium.

BEE International: Homogenizers for Product Improvement

BEE International carries a wide selection of homogenization equipment that can aid production in your industry, regardless of the size of your manufacturing area. Our homogenizers are well suited for laboratory, research and development, pilot plant, and even full scale production environments. By utilizing the combined forces of shear, turbulence, cavitation, and impact, our homogenization equipment produces results that are reliably, repeatable, and high quality. Your customers won’t be the only ones amazed at the results!

Learn more about our homogenization equipment by contacting us today. We look forward to working with you on your next manufacturing project, big or small.

For more information on homgenization and cell lysis methods, download our FREE eBook:

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4 Benefits of High Pressure Homogenization

Posted by Deb Shechter on Mar 30, 2017 12:30:00 PM

benefits of high pressure homogenizationHomogenization is an incredibly useful technique that is becoming more heavily utilized in a number of manufacturing industries, including pharmaceutical, biotech, cosmetic, and food. Homogenization is an important step in creating high-quality products that consumers have grown to expect. With benefits including improved taste, texture, and consistency of products – when then translate to increased sales and customer satisfaction – it’s no wonder that more and more industries are clamoring to get a homogenizer of their own! Continue reading to learn about more benefits of high pressure homogenization.

Consistency in Composition of Products

High pressure homogenization allows for an even dispersion of ingredients within a medium; this is incredibly important for the pharmaceutical industry, where active ingredients need to be evenly dispersed within a pill, tablet, capsule, or syrup – and within the cosmetic industry, where customers expect their lotions and creams to have an even texture and appearance.

Increased Rate of Dissolution

Homogenization involves pushing materials through a shaft to create smaller particles; this is especially important in the world of dissolution, where smaller and finer particles facilitate easier dissolution. In the pharmaceutical industry, this impacts both the bioavailability and efficacy of drugs that are produced.

Greater Stability of Final Products

A successfully homogenized product contains particles that are so small and fine that they do not fall out of solution. This is incredibly important to the food and beverage industry – the last thing a customer wants is a bottle of juice that has particles visibly falling out of solution!

Decreased Cost

Another benefit of high pressure homogenization is its ability to not only enhance the safety of products – especially important both in the food and pharmaceutical industries – but to reduce overall costs as well. Effective high pressure homogenization often results in a reduced need for processing chemicals and thermal processing, and can also decrease the potential costs of product recalls.

BEE International: High Quality High Pressure Homogenizers

At BEE International, we take pride in our wide array of homogenizing equipment. We offer an extensive 1-year warranty on parts and labor, with unmatched customer service and training. Our homogenization equipment utilizes the forces of shear, impact, cavitation and turbulence to ensure the highest quality of emulsions, dispersions, and finished product. Our equipment is well-suited for laboratory, research and development, pilot plant, and industrial use. To learn more about our selection of homogenizers, please contact us today for more information.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

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Micro DeBEE vs. Mini DeBEE High Pressure Homogenizers

Posted by David Shechter on Mar 29, 2017 12:30:00 PM

Homogenization, otherwise known as particle size reduction, is heavility utilized in a number of industries. The next time you’re enjoying your smooth, silky body lotion, or your next deliciously creamy glass of milk, you can thank the power of homogenization. It is because of this process that particles are able to be evenly and thoroughly dispersed throughout a number of different mediums, resulting in improved texture, visual appearance, and taste, and adding up to big savings in the form of customer satisfaction and repeat business. With all of the benefits of homogenization, its no wonder that more and more industries are looking to jump on board!

However, before choosing the right homogenizer for the job, it is important to have a good understanding of your options. Here at BEE International, we have a number of high quality high pressure homogenizers that are well suited to complete the task at hand. Two of our most popular homogenizers, the Micro DeBEE and the Nano DeBEE, are often used in laboratory settings. But what are the differences, and which one should you choose for your project? Continue reading to learn more!

Micro DeBEE Laboratory Homogenizer

Micro DeBEE.jpg

The Micro DeBEE Laboratory Homogenizer is an Air Operated, Benchtop unit that is suitable for a broad range of industrial and laboratory applications. This unit is small, but mighty, boasting a capacity of 15 liters per hour. It is suitable for cell disruption, particle size reduction, work with polymers and liposomes, and the creation of stable nano and micro emulsions and dispersions.

Mini DeBEE Laboratory Homogenizer

Mini DeBEE.jpg

The Mini DeBEE Laboratory Homogenizer is larger than the Micro DeBEE, but don’t let the size fool you – while it can be used for larger scale production, it is suitable for laboratory production as well.  This unit operates at up to 45,000 psi, and allows for repeatability and scalability of results. It is also easy to clean and maintain, with no disassembly required.

BEE International: The Best Choice For Homogenization Equipment

No matter what your application is, BEE International is sure to have the right homogenizer for the job. We are here to answer any and all questions that you may have, and we offer lifetime training for new employees and students. Please contact us today to learn more about our high quality homogenizing equipment. We look forward to working with you on your next project.

For more information on homogenizers, cell lysis, and how to choose the right method, download our FREE eBook:

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How the DeBEE 2000 Can Benefit the Manufacturing Process

Posted by Tal Shechter on Mar 23, 2017 12:30:00 PM

DeBEE 2000Homogenization is used in a number of important industries, including cosmetic, food, pharmaceutical, and biotech. This process is more simply known as particle size reduction, and occurs when a particle is made smaller. This simple act has countless benefits: increased quality of texture, taste, and appearance, tissues and particles that are more readily studied in laboratory settings, and lower production costs. With all of these benefits (and many more!) it’s no wonder that more and more industries are looking to get involved in this powerful process by purchasing a homogenizer for their industry.

However, before taking on this task, it is important to understand the options that are available. BEE International is here to help! BEE – short for Best Emulsifying Equipment – stays true to its name with a number of machines that can help with the process of homogenization. Our homogenizers are well suited for virtually any application and just about any setting, from a smaller laboratory or R&D setting, to pilot plants, all the way to large scale manufacturing plants.

One of our more popular laboratory scale models is the DeBEE 2000. What does this powerful piece of equipment do? How can it help in your industry? What benefits and features does it offer? Continue reading to learn the answers to all of those questions and more. 

The DeBEE 2000 is designed to facilitate process development in a laboratory or R&D setting.  This series includes the DeBEE 2000-45-30, DeBEE 2000-45-60, DeBEE 2000-30-60, DeBEE 2000-25-100, and DeBEE 2000-20-120 models. The technology contains a proprietary homogenizing cell that allows for unmatched results in fewer passes. The DeBEE 2000 series is also well suited to produce results that are not just repeatable, but scalable as well. Other features include:

  • Easy to clean
  • Variable operating pressure up to 45,000psi
  • Modular design for lower cost replacement parts
  • PLC control and monitoring for simple operation
  • Constant process pressure for tighter product distribution
  • Ability to control cavitation, pressure, shear, and impact
  • Adjustable back pressure
  • Stainless steel enclosure
  • Dual feed
  • Dual jet
  • Automatic Clean in Place (CIP)

To learn more about the DeBEE 2000, as well as how we at BEE International can help with your next homogenization project, please contact us today. Our free product guide that explains more of the features in detail is available for download here.

For more information on how to achieve efficient and consistent particle size reduction results, download our FREE eBook:

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Homogenization in the Chemical Industry: What to Look for in a Homogenizer

Posted by Deb Shechter on Mar 22, 2017 3:00:00 PM

homogenizationHomogenization, more simply known as particle size reduction, is a technique that is gaining popularity in a number of industries: cosmetic, pharmaceutical, and food are just a few of the industries that are utilizing technique. But did you know that the chemical industry also utilizes the process of homogenization? It’s true – homogenizers are being used more and more in this growing field. However, before you choose your next homogenizer for the chemical industry, it is important to know what to look for in a homogenizer. Continue reading to learn more about how homogenizers are used in the chemical field, as well as what features you should be looking for before choosing your next piece of homogenizing equipment.

Size Reduction Capabilities

When looking for your next homogenizer, it is important that it has the all-important capability to reduce size of even the most challenging of materials. A quality homogenizer will be able to handle both new and unusual particle morphologies while preserving existing morphologies, and will be able to handle one-step blending and formulation.

Dispersion and Emulsion Creation

In addition to being able to effectively reduce particle size, a high quality homogenizer will be able to create dispersions and emulsions with ease. A good homogenizer should be able to create dispersions and emulsions that allow for maximum particle packing, better particle coating during formulations, smoother surface quality, and increased conductivity.

BEE Homogenizers – What We Offer

If you are on the market for a high quality high pressure homogenizer for the chemical industry, you are in the right place. Our homogenizers offer the top size reduction capabilities on the market, the ability to create even dispersions and emulsions, and allow for accelerated chemical processes. Other benefits and features include:

  • Smoother surface quality of emulsions and dispersions
  • Menu guided maintenance and calibration
  • Data collection
  • Clean in Place technology
  • Synchronized pump system for constant pressure
  • Pharma/Bio/Food sanitary
  • cGMP and CE compliant
  • Password operated protection
  • Vertical and horizontal intensifiers
  • Maximum pressure of up to 45,000 psi

We also offer a 1 year manufacturer’s warranty, and availability to train new operators of our systems. Regardless of the setting or atmosphere, our homogenizers are sure to work for your application – whether it is in a smaller lab setting or a larger industrial zone. For more information on the homogenizers that we have to offer, please contact us today. We look forward to working with you on your next big project.

For more information on cell lysis and how to choose the right method, download our FREE eBook:

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