Food Homogenization 101: What You Need to Know

Posted by David Shechter on Dec 13, 2017 11:30:00 AM

food homogenizationThe food and beverage industry continues to expand and diversify, especially as consumers look for more healthful products that fit both their lifestyle and budget. Companies must find ways to create and market products to differentiate them from their many competitors while ensuring their goods have the taste, freshness and nutrients on which customers have come to rely.

A common method food processing and manufacturing companies utilize to efficiently, cost-effectively and safely produce their goods is high-pressure homogenization. It not only reduces particle size through forces including high pressure, shear, turbulence, acceleration and impact but also allows for the stable and consistent production of emulsions, suspensions and other commodities that necessitate a liquid suspended in another liquid.

Though one of the most well-known uses of homogenization in the food and beverage industry is for milk, it is also widely used in the manufacture of sauces, spreads, salad dressings, fruit juices and concentrates, fish and meat paté, sweeteners, baby food, egg product, other dairy products and more. The homogenization pressures used for these products typically range between 20 and 60 MPa, but some homogenizers can reach pressures of up to 400 MPa. This magnitude of pressure leads to microbial and enzyme inactivation, which enhances the safety and shelf life of perishable foods while reducing the thermal effects on the foods’ functional and sensory qualities.

Once a company achieves its ideal product, the product needs to be reproduced on a larger scale without losing the characteristics that make it desirable by customers. If it doesn’t offer the same taste and texture on a regular basis, the manufacturer may not only lose customers and their funds but also obtain a damaged reputation.

Food homogenizers help deliver a product with uniform texture, flavoring and taste through a scalable and cost-effective process that allows for a longer period of freshness than food comprised of larger particles. The smaller the particles, the longer the structure of the product can be maintained. Food homogenizers’ ability to use pressure instead of heat preserves critical nutritional components naturally found in a food, enabling them to be available for consumption.

Although high-pressure homogenization may potentially replace thermal methods of food preparation, it does not effectively produce solid foods or ones formed from large particles. Also, because it uses force instead of thermal action, homogenization does not sterilize foods or beverages, requiring it to be accomplished through a separate process.

BEE International: Help in Finding the Best Food Homogenizer

The key to purchasing the right food homogenizer for your business needs is selecting one that can achieve consistent particle size distribution on a scalable basis. At BEE International, our equipment can engineer particle sizes at or below 100 nm, a benefit favorable for most any product in the food and beverage industry. Our products are trusted by researchers and laboratory managers around the world, and our unparalleled customer service will make finding the right product a breeze for companies of all sizes.

Contact us today to find out more about how BEE International can aid your particle size reduction process. 

For more information on the key factors to consider when choosing a cell lysis method, download our FREE eBook:

New Call-to-action

Liquid Mixers vs High Pressure Homogenizers: Which Is Right for You?

Posted by Deb Shechter on Dec 6, 2017 11:30:00 AM

liquid mixersIt’s not uncommon for terms or even buzzwords in various industries to be similar but have different applications. For example, in the healthcare industry, electronic medical and electronic health records may sound the same. However, electronic medical records (EMRs) are a digital version of the paper charts in the clinician’s office that contain the medical and treatment history of the patients in one practice, while electronic health records (EHRs) focus on the total health of the patient, provide a broader view on a patient’s care and are designed to share information with other healthcare providers.

Similarly, though the terms “liquid homogenization” and “high-pressure homogenization” appear comparable, each has its own characteristics and primary uses. Homogenization in general can be defined as the reduction of particle size of any given molecule and is a process utilized often in the pharmaceutical, biotech, cosmetic and pharmaceutical industries. Its benefits include more even particle distribution, improved texture and enhanced appearance and taste.

Liquid homogenization, achieved by using a liquid mixer, and high pressure homogenization offer similar outcomes yet use distinct processes. The mixing processes and mixer designs chosen are determined by the nature of the materials to be mixed. Essentially, the type of product you select for your laboratory depends on its downstream applications and the cell types being used. 

In this blog, we’ll describe the differences between liquid and high-pressure homogenization and list pros and cons of each to help you decide which one is best suited to your business needs. Whichever you choose, it’s important that it has the flexibility to meet the various needs of a laboratory. 

Liquid Homogenization

Widely used for cell disruption of cultured cells and small sample volumes, liquid homogenization requires a sample to manually be forced through a narrow space, thereby shearing membranes and decreasing particle size. There are three most common types of liquid mixers used: the Dounce homogenizer (used for gently lysing single cell suspensions), Potter-Elvehjem homogenizer (used with delicate tissues) and the French press (used for small sample volumes). In addition to being suitable for operation at higher temperatures and easy to maintain, liquid mixers offer enhanced repeatability and a lower power requirement. Nevertheless, the throughput from all three models is fairly low, and they may not provide enough scalability. 

High-pressure Homogenization 

Utilized for numerous products from the chemical and biotechnology industries and products such as pharmaceutical tablet coatings, vaccinations and creams, high-pressure homogenization uses multiple mechanical forces (such as turbulence, cavitation and shear) along with intensive pressure to achieve micronization and membrane lysis. Similar to liquid mixers, high-pressure homogenizers work by forcing cell suspensions through a very narrow channel under pressure. Unlike the manual requirement of liquid homogenizers, though, high-pressure units run automatically and are often made to be scaled from laboratory experimentation to manufacturing.

Benefits of high-pressure homogenization include an increased rate of dissolution, ease of operation, cost and time effectiveness, consistency in composition of products, greater stability of final products due to a stable emulsion and upgraded scalability and repeatability. High-pressure homogenization also has the ability to reduce particle size to levels that are not achievable by most other mixing processes. Because they tend to be large and very heavy, high-pressure homogenizers are typically used for large volume processing and consume more power than liquid mixers. They sometimes require more complex cleaning, cannot handle large particles or high-fiber materials and aren’t the most suitable for high temperature materials. 

BEE: The Industry Leader in High-Pressure Homogenizers

BEE International offers a wide variety of high pressure homogenizers to meet the needs of virtually any industry. Unlike liquid mixers, our homogenizers are suited for large samples and offer large throughputs, making them ideal for laboratory, pilot plant and even industrial use. In addition, our easy-to-use equipment produces higher yield in less time and utilizes multiple forces – shear, turbulence, impact and cavitation – to allow for results that are reliable, repeatable and high quality.

There are plenty of companies on the market to select equipment from; however, the product can be of higher quality and more even consistency when run through top-shelf equipment, most frequently in the form of a homogenizer. BEE International Technologies is trusted by researchers around the world for both our laboratory homogenizers and associated customer support. Learn about how BEE’s products can maximize your homogenization processes by contacting us today. 

For more information on how to choose the right cell lysis method for your application, download our FREE eBook:

New Call-to-action

How Do Inline Mixers Work Differently Than High-pressure Homogenizers?

Posted by Tal Shechter on Dec 1, 2017 11:30:00 AM

inline mixersWhen they hear the term “homogenization,” many people think of milk. In fact, one of the first applications of homogenization came in the processing of milk. Derived from the Greek word “homogenos” (homos meaning same and genos meaning kind), it is defined as the process of reducing the particle size of an object and is also known as micronization.

Homogenization works by forcing a sample through a narrow space through multiple mechanical forces, thereby producing a stable and consistent product. Easily scalable, it is used by multiple industries, including pharmaceutical, biotech, cosmetic and food, in order to optimize their finished product.

Under the umbrella of homogenization lie two different methods: inline mixing and high-pressure homogenization. Read on to learn the differences between how the two work and advantages associated with each.

Inline Mixing  

Positioned within the production line and aligned with the flow of product, inline mixers consist of a stationary stator and an inside rotor that turns at high speeds. The rotor–stator device is contained in a casing with an inlet at one end and an outlet at the other, and the rotor is driven through a seal. Mixing occurs when a sample is drawn in through one of the mixing heads while the blades rotate and is then expelled at a high velocity through an opening in the stator. The inline term comes into play around the mode of sample entry into the mixing chamber.

Inline mixers feed and output material in a continuous stream, allowing material to often be perfectly hydrated, emulsified or homogenized in a single pass. They differ from other types of homogenization wherein large amounts of ingredients are mixed in a standalone unit before going through the homogenization process. Designed to handle all types of tasks, including emulsifying, suspending, dispersing, blending and more, inline mixers are suitable and useful for applications where larger quantities are needed for production and continuous processing and homogenization is needed during the manufacturing process. In addition to being faster than their high-pressure counterparts, they allow for a more controlled and continuous mixing environment, improve yields, use less energy and increase capacities.

High-pressure Homogenization

Whereas inline mixers rely on rotor/stator shearing action, high-pressure homogenizers force a sample through a narrow space using force and high pressure, thereby reducing particle size or lysing cells. They consist of a high-pressure pump and a disruption unit which enable a continuous homogenization. The higher the amount of energy applied during the homogenization process, the smaller the particle size or the more complete the cell lysis. The pressure along with the action of multiple forces yields impactful results in only one or two passes. Benefits of high-pressure homogenization include consistency in composition of products, greater stability of final products and decreased cost. Also high-pressure homogenizers allow users to set operating parameters - pressure, temperature, number of passes, valve and impingement design and flow rate – for a particular homogenization.

BEE International: Your Homogenization Equipment Headquarters

At BEE International, we offer a wide selection of homogenizers that meet the needs of manufacturers across multiple industries, including cosmetic, pharmaceutical, biotech and more. Our products can help enhance your production, improve product quality and streamline your operations, all in combination with our unmatched customer service. Contact us today to learn more about our homogenization equipment and find out what product(s) is best suited to your business needs.

For more information on particle size reduction and how to achieve efficient and consistent results, download our FREE eBook:

New Call-to-action

How to Select a Homogenizer for Chemical Applications

Posted by Deb Shechter on Oct 31, 2017 11:30:00 PM

Portrait of a smiling scientist with colleagues at work in the laboratory-280003-edited.jpegHomogenization, also known as particle size reduction or micronization, is used across many industries – including pharmaceutical, chemical, food, and cosmetic -- to create stable emulsions and dispersions. While there are a number of machines that can perform the task of homogenization, it is important to choose the right homogenizer to ensure the best result with the highest level of quality. Continue reading to learn more about some important things you should look for when choosing a homogenizer for chemical applications.  

Dispersion Creation

Dispersions, also known as suspensions, consist of solid particles distributed throughout a continuous medium. Examples of dispersions include polymers, petroleum additives, paints, and acrylics. It is important to create high quality dispersions in the production of these items to ensure maximum particle packing, increased conductivity, and improved overall surface quality.  High quality dispersions results in a higher quality end product, which almost always translates to a better bottom line.

Particle Size Reduction Capabilities

When choosing a homogenizer, it is important to choose a high pressure homogenizer that can efficiently and readily decrease particle sizes. This process, also known as micronization, results in smaller particle sizes, which help facilitate easier dissolution, increased product stability, and higher overall quality. This results in increased customer satisfaction as well as reduced costs of production.

High Pressure Homogenizers from BEE International

BEE International offers a number of high pressure homogenizers to meet the needs of virtually every industry. Our homogenizers, which include the Nano DeBEE and Micro DeBEE, just to name a few, are ideal for just about any environment, including laboratory and R&D settings, pilot plants, and industrial manufacturing zones. In addition, our homogenizers offer the following benefits and features:

  • Ability to scale to manufacturing
  • Unique processing set-ups to address specific processing challenges
  • Dual Feeds to allow for the addition of abrasive and viscous materials
  • Dual Jets that are capable for reducing particle sizes for the hardest of materials
  • Pressurized feeds that allow formation and dispersion of final products in one step
  • Increase in dense cross section of final products
  • Better particle coating during formulations

Contact us today to learn more about our high pressure homogenizers and how they can help with particle size reduction in your industry. If you’re looking to achieve particle size reduction efficiently and consistently, download our FREE eBook below:

New Call-to-action

What are Inline Homogenizers Used For?

Posted by Tal Shechter on Oct 30, 2017 11:30:00 PM

Business man looking at wall with a bright question mark concept-222794-edited.jpegOne important question to answer when beginning any manufacturing project requiring homogenization, micronization, or particle size reduction is an obvious one: what is homogenization, and what are homogenizers used for? Finding out the answers to these two important questions is an important first step in determining the type of homogenizer to purchase and ultimately use.  Various types of homogenizers exist, all with a multitude of pros and cons. In this article, we will focus on discussing one especially popular type of homogenizer -- the Inline Homogenizer.

Inline Homogenizers are designed to handle all types of tasks, including emulsifying, suspending, dispersing, and blending. These homogenizers are used in a variety of industries, including pharmaceutical, cosmetic, biological, and chemical. What makes inline homogenizers unique? One key feature is the fact that they are positioned within the production line, aligned with the flow of product.  Inline homogenization is different from other types of homogenization, such as batch homogenization, where large amounts of ingredients are mixed in a standalone unit before going through the homogenization process.

Inline homogenizers are suitable for applications where larger quantities are needed for production. Since they are able to be installed right on the production line, they are especially useful for applications where continuous processing and homogenization is needed during the manufacturing process.

The benefits of inline homogenization are endless. Not only is inline homogenization a faster process, especially in situations where larger quantities are being produced, it is also a more economical option, since additional mixing tanks and vessels are usually not needed. Inline homogenization also ensures consistency throughout a production run, since homogenization is occurring continuously on the production line.

BEE International offers a wide variety of inline homogenizers to meet the need of virtually any industry. Our Laboratory, Pilot and Industrial Homogenizers are suitable for all production needs, from small scale R&D applications up to full scale, 24/7 industrial operations. Our DeBEE 4000 homogenizer offers the following features and benefits:

  • Complete Automation, Compliance, and Production Capacity of 120 LPH and up
  • Multiple Vertical Process Intensifiers
  • An advanced, user-friendly interface
  • CE Compliant
  • Pharma/Bio/Food Sanitary
  • Synchronized Pump System for Constant Pressure
  • Advanced Data Collection and Gathering
  • Clean in Place (CIP)
  • Programmable Maintenance Schedule with Alarms
  • In-line Spare Intensifier
  • User Management
  • Data Trending

For more information on the Inline Homogenizers in our assortment, as well as our full suite of homogenization equipment, please contact us. We are looking forward to assisting you with your next homogenization project!

Need to Efficiently & Consistently Reduce Particle Size In-Line?

Many of our manufacturing partners that use inline homogenizers need to reduce the particle size of their application in order to pass it on to the next processing stage. With a variety of particle size reduction techniques, including homogenization, how can you find the best method? Check out our free eBook “How to Achieve Efficient & Consistent Particle Size Reduction” and learn which method is best for you:

New Call-to-action

How to Care for Your Homogenizer Equipment

Posted by Deb Shechter on Oct 27, 2017 11:30:00 AM

homogenizer equipment.jpgHomogenization, also known as particle size reduction or micronization, is used across many industries – including pharmaceutical, chemical, food, and cosmetic -- to create stable emulsions and dispersions. And while this technology has proven – and continues to prove – to be very powerful and useful, the homogenization process is only as good as the equipment that is used to undergo the process. For this reason, it is critically important to properly care for your homogenizer equipment. Continue reading to learn more about how to care for your homogenizer equipment so you can reap the benefits of its many features for years to come.

Well-cared for homogenizers can last for many years, but only if they are properly maintained. High quality homogenizers – like the ones sold by us here at BEE International – should be on a regular maintenance schedule to ensure continuous working condition. In addition, it is important that your homogenizer is not immersed in water or exposed to harmful fumes.

In addition, there are a number of preventive maintenance tasks that should be regularly completed with your homogenizer:

  • Regular replacement of motor unit brushes
  • Lubrication of bearings using a liquid sample/medium
  • Regular exterior cleaning of your homogenizer (using just soap and water is sufficient).

High Pressure Homogenizers from BEE International

BEE International offers a number of high pressure homogenizers to meet the needs of virtually every industry. Our homogenizers, which include the Nano DeBEE and Micro DeBEE, just to name a few, are ideal for just about any environment, including laboratory and R&D settings, pilot plants, and industrial manufacturing zones. In addition, our homogenizers offer the following benefits and features:

  • Ability to scale up from research and development to manufacturing
  • Unique processing set-ups to address specific processing challenges
  • Dual Feeds to allow for the addition of abrasive and viscous materials
  • Dual Jets that are capable for reducing particle sizes for the hardest of materials
  • Pressurized feeds that allow formation and dispersion of final products in one step
  • Increase in dense cross section of final products
  • Better particle coating during formulations

Contact us today to learn more about our high pressure homogenizers and how they can help with particle size reduction in your industry. If you have any additional questions about proper maintenance for your BEE Homogenizer, please don’t hesitate to reach out to a member of our team.

Learn More About Homogenizer Applications

Whether you are trying to lyse cells more efficiently or reduce particle size more consistently, we have FREE eBooks written to help you achieve both goals. Download each by clicking on their covers below:

beei-ebook.jpghow-to-achieve-efficient-and-consistent-particle-size-reduction.jpg

How to Pick Out a Homogenizer for Cell Lysis

Posted by David Shechter on Oct 26, 2017 11:30:00 PM

Thinking woman in glasses looking up with light idea bulb above head isolated on gray wall background-603464-edited.jpegCell lysis is commonly described as the process of releasing biological molecules from inside a cell, and is a powerful method utilized in a variety of manufacturing industries, including pharmaceutical, cosmetic, biotech, and R&D settings. With the popularity of this technology, more and more industry professionals are seeking out homogenizers to assist with the process of cell lysis. However, before settling on the right homogenizer for the job, it is important to understand more about cell lysis and what it entails.

During the process of cell lysis, in order to thoroughly study and analyze the behavior of molecules, the cells that produce the molecules in question must be disrupted. Disruption of cells can be achieved in numerous ways, including cryopulverization, nitrogen decompression, or through using a homogenizer.  Each method comes with varying degrees of complexity, ease, and success.

Cryopulverization is one way of accomplishing cell lysis, and is most often used for cellular samples with a tough outer matrix, such as cartilage, connective tissue, or seeds. In this method, the samples are reduced to a powder through the use of liquid nitrogen and impact pulverization. This method, while successful, is often time consuming and expensive.

Nitrogen decompression, as the name suggests, uses large quantities of nitrogen to achieve cell lysis. In this particular method, nitrogen is dissolved in the cell under very high pressures. When the pressure is released, the nitrogen violently escapes the cell, causing disruption and breakage of the cell walls. While nitrogen decompression is successful in disrupting certain types of cells – plant cells, bacteria, and other fragile cell types are most receptive to this treatment – it has not been proven to be effective in disrupting cells with tougher outer matrices, such as yeast, spores, and fungus.

Homogenization is arguably the most widely used method of cell lysis, especially for small volumes of cells and/or cultured cells. This method involves the use of shearing force on the cell. This is achieved by forcing the small cell through an even smaller sized orifice. This removes the outer layer and lyses the cell.

BEE International offers a number of high-quality homogenizers to meet the needs of any industry when it comes to the process of cell lysis and disruption. Our laboratory grade homogenizers include the Nano DeBEE, Micro DeBEE, and Mini DeBEE – all three are easy to use, offer consistent and reliable results, and easily scale up for full scale production. In addition, our homogenizers offer maximum experimentation capabilities, the ability to change flow, pressure, shear, and impact settings, and offer high pressures up to 45,000 PSI for maximum effectiveness with cell lysis and disruption.

Contact us today to learn more about how our line of homogenizers can help you meet your production needs. We are more than happy to help you get started on your next big project, and to help you choose the right homogenizer for the most efficient and effective cell lysis.

How to Choose A Cell Lysis Method

If you’re looking for more information on how to pick the best cell lysis method for your application, download our free eBook “7 Key Factors to Consider When Choosing a Cell Lysis Method”. This eBook contains practical, clear facts and insights for live science researchers and laboratory managers who want to improve existing products, enhance efficient manufacturing processes, and achieve remarkable results for new innovations. Download it here:

New Call-to-action

5 Facts About Homogenizers for the Biotech Industry

Posted by Deb Shechter on Aug 30, 2017 11:30:00 AM

Image of DNA strand against colour background-285750-edited.jpegHomogenization in the Biotech industry is used for many applications, including cell disruption, particle size reduction, micro and nano emulsions, and dispersions. In this growing industry, homogenizers are used to effectively rupture yeast, bacteria, E. coli, fungi cells, and more.

Keep reading to discover five interesting facts about homogenizers for the biotech industry.

  • The first homogenizer was invented in 1899 by Auguste Gaulin, a French inventor. This early homogenizer was developed to aid the milk industry, and broke milk’s fat globules into smaller, more uniform sizes in order to resist separation.
  • Modern homogenization involves a two step process: particles are first pushed through tubes or pores to reduce their size, and they are then subjected to high pressures to further reduce their particle size.
  • In the Biotech industry, homogenization is more commonly referred to as micronization or cell fractionation.
  • Cell fractionation is a procedure for rupturing cells and creating separation and suspension of cell components in a given medium (usually water or an organic solvent).
  • Cell fractionation involves three steps: Extraction, Homogenization, and Centrifugation. During the extraction phase, molecules, tissues, or cells are isolated and suspended in an isotonic solution. During the homogenization step, the cell is ruptured to create a smaller particle size.

At BEE International, we offer a number of industrial-grade homogenizers that use state of the art technology to help with emulsification, dispersion, and grinding of particles. In addition to our revolutionary technology, we also offer homogenizers that utilize a constant processing pressure. This allows our equipment to produce consistent rates of pressure and eliminates the risk of any contamination.

At BEE International, our homogenizers improve results in the biotech industry, allowing this important industry to create more effective medications, chemicals, vaccines, and more. Please contact us today to learn more about our equipment and how we can assist with your next big project. We look forward to working with you.

For more information on homogenizers and cell lysis methods, download our FREE eBook:

New Call-to-action

3 Advantages of Homogenizers for the Pharmaceutical Industry

Posted by Tal Shechter on Aug 23, 2017 11:30:00 AM

homogenizer for pharmaceuticalHomogenization – also known as cell fractionation or micronization – is the process of dividing particles into microscopic sizes, ranging anywhere from 0.5 microns to 2 microns, depending on the application. Homogenizers play an important role in the pharmaceutical industry, and are commonly used for dispersions, emulsions, particle size reduction, and cell rupture.

Keep reading to discover the advantages of homogenizers for pharmaceutical products in the ever-growing pharmaceutical industry.

1. Reduced Particle Size

Effective homogenization results in a smaller particle size and more even distribution of active ingredients. For topical pharmaceutical products, such as medicated creams, lotions, and ointments, this allows for those medications to absorb more rapidly into the skin. A reduction in particle size increases the surface area of critical (and often expensive) active ingredients, which allows for an even dispersion of the active ingredients in the product, which increases efficacy of pharmaceutical products and lowers cost as well.

2. Increased Stability of Pharmaceutical Products

High-quality homogenizers have the ability to reduce the particle size of critical active ingredients, which in some cases can help improve the stability of these otherwise unstable active ingredients. Some critical active ingredients used in the pharmaceutical industry are solid at room temperature, and only moderately soluble in water or organic solvents. Effective homogenization can reduce these otherwise difficult to work with active ingredients into a small enough size that they have increased solubility in these mediums, many of which can work further to increase the shelf life and stability of the active ingredients.

3. Increased Reliability in Manufacturing Settings

BEE International has a number of first-class homogenizers that can meet the needs of manufacturers in the pharmaceutical industry. Our industrial homogenizers are designed for cGMP manufacturing, and offer reliability suitable for all industries, including those with a 24/7 operating schedule. Our proprietary software offers touch screen guided operation, data collection, security, on-line maintenance schedules and alarms, and configurable recipes and capacities.

BEE International industrial homogenizers and high pressure homogenizers are manufacturing pharmaceutical, chemical, life sciences, food, cosmetic products, and more. Contact us today to discuss the benefits our homogenizers can bring to manufacturing your company’s products. You can also download our free eBook, “Advantages of BEE Homogenizers for the Pharmaceutical Industry” here.

New Call-to-action

Producing Effective Dispersions

Posted by Deb Shechter on Jul 18, 2017 11:00:00 AM

Producing Effective DispersionsProducing effective dispersions is a challenge that many industries – including pharmaceutical, biotech, and cosmetic – face on a continuous basis. In the growing world of dispersions, cell lysis,  micronization of particles, and other applications requiring the use of a homogenizer, bridging the gap between R&D and manufacturing is a costly and often unsuccessful challenge.

BEE International has extensive experience in the field of development and production of homogenization equipment, suitable for virtually any application, beginning from the early stages of planning, research and development work, and scale up, all the way to final implementation and production.

When it comes to producing dispersions, it is a task that requires much preparation, foresight, and planning, but with proper preparation, knowledge, and tools, it is a satisfying and profitable endeavor.

Replicating dispersion in a large-scale production environment that has been successfully implemented in a smaller laboratory setting can be difficult. Even when a satisfactory particle size has been achieved, when produced on a larger scale, it may not have the same qualities and characteristics as what was created in the laboratory setting. Inconsistencies can be observed in many areas, including (but not limited to):

  • Differing size and/or densities of media
  • Differing throughput rates of media
  • Mill wear and changes in millbase viscosity
  • Dispersion at differing speed/rate/power

The process of dispersion requires a high level of attention to detail, accurate input variables, and consistent design criteria. BEE International offers high quality laboratory systems that address and standardize all of the numerous factors that can affect a scaled up dispersion process. Our homogenizers, including the Nano DeBEE 45-2, Micro DeBEE 45, and Mini DeBEE 30, are built for reliability and repeatability, and are able to keep up with the high pace of a full-scale 24/7 manufacturing environment.  

Our pilot plant homogenizers, designed for scaling up homogenization, micronization, and dispersion from the R&D stage all the way to full-blown production, can be customized to fit your schedule, production needs, and budget.  Our homogenizers include key features for successful  scaling of dispersions, including:

  • Low-High operating pressure from 5,000-45,000psi
  • PLC panel to control process pressure, temperature, and other parameters
  • Constant process pressure
  • Custom process configurations to enable control of shear and impact
  • Adjustable back pressure
  • Heat exchangers for cooling of product
  • Guaranteed scale up from R&D to manufacturing

BEE International’s DeBEE 2000, our pilot scale high pressure homogenizer, contains a 10 horsepower motor which converts hydraulic power through high pressure cylinders. The unit is capable of reaching up to 45,000psi and is suitable for the scale up needs of most major manufacturing industries.

Contact us for more information on our pilot plant homogenizers and other equipment to meet your dispersion scale up needs. 

For more information on key factors to consider when choosing a cell lysis method, check out our FREE eBook today: 

New Call-to-action