BEE International Blog

When Is It Appropriate to Use an Inline Homogenizer?

Posted by David Shechter on Oct 20, 2016 12:30:00 PM

homogenizerAn inline homogenizer is one that is positioned within the production line; in the flowing stream of product. This as opposed to a batch homogenizer, which is a stand-alone unit where all the ingredients are mixed in a tank before being homogenized.

While batch homogenizers are suitable for smaller volumes (<400 gallons), inline homogenizers are good for any production volumes, but are especially ideal for continuous processing of larger volumes of emulsions and dispersions.

Inline homogenizers are an efficient and economical choice. They offer greater control over the mixing process than batch homogenizers. Every drop of product receives the same amount of mixing, leading to reduced processing times and consistent results for every batch.

Great for Food and Pharmaceutical Applications

The FDA imposes stringent regulations on the production of foodstuffs and pharmaceutical products, and inline process design is one of these production regulations. Inline homogenizers significantly reduce the chances of contamination as the product remains within a closed pipeline system. Inline homogenizers also work well with CIP systems, as they are quick to disassemble, clean and maintain.

Inline homogenizers positively affect the aesthetics of the product. Along with creating stable emulsions, they can also rapidly dissolve solid materials, and accelerate chemical reactions. Ingredients are more completely utilized, resulting in a smoother, thicker product.

BEE International Inline High Pressure Homogenizers

Our DeBEE High Pressure Homogenizing Systems are proven reliable in continuous inline operation due to:

  • EASY OPERATION with computerized control and monitoring
  • BEST RESULTS from constant pressure to the homogenizing cell
  • CONTINUED OPERATION with online spare intensifier pump, dual seals
  • and condition monitoring
  • LOW MAINTENANCE with slower and fewer strokes per minute
  • SIMPLE MAINTENANCE with easy access and computer scheduling
  • LOW COST SPARES with standard hydraulic power units
  • EXACT PERFORMANCE with modular tunable homogenizing cell

All of our systems produce the same results. From the laboratory, up to pilot, and through to industrial volumes, our high pressure homogenizers consistently produce the same results and have a reputation for reliability. Contact us to learn more about our high pressure homogenization products and technology.

If you're looking for more information on how to achieve efficient and consistent particle size reduction in your applications, check out our FREE eBook here:

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Topics: Homogenizer

Why Should You Choose BEE International as Your Homogenizer Manufacturer?

Posted by Deb Shechter on Oct 18, 2016 12:30:00 PM

homogenizer manufacturerOnce you try a DeBEE High Pressure Homogenizer, we are confident that the results will speak for themselves. Our high pressure homogenizers reliably and consistently produce uniform particle size reduction and high yield cell disruption; and results are always 100% scalable up to manufacturing volumes. High quality results in fewer passes translates into time and money saved for your business.

Here are several more reasons to choose BEE International as your high pressure homogenizer provider:

Our Reputation

BEE International is an established and well-respected company that has been in business for 22 years. Our high pressure homogenizers are in operation in commercial and academic facilities across the globe. The DeBEE brand is synonymous with quality, and we strive to always uphold these high standards of excellence.

Our Expertise

We specialize in high energy mixing for particle size reduction and cell lysis: it’s all we do, and we do it very well! Our high pressure homogenizers utilize ALL available mechanical forces: including cavitation, turbulence, high shear and impact. Process intensity is adjustable from 2,000 - 45,000 psi / 150 - 3100 bar, and our modular approach allows you to adjust these forces in order to optimize your product.

Our Application Support

We would love to partner with you in developing new products and improving your existing ones. Our scientists and engineers at BEE International have many years of experience and product development knowledge, and we are here to help you! Click here to learn more about our application support and sample testing program.  

Our Lifetime Training

DeBEE High Pressure Homogenizers are a lifetime purchase, and we’re proud to provide lifetime training for all of our products. Our flexible training programs allow for pre- or post-installation training, and we would be happy to train your future operators later down the line.

Our Technical Support

BEE International offers free technical support via telephone or email. Contact us any time, and our helpful technical support staff will work with you in resolving your query in record time.

Our After-Sales Services

A high pressure homogenizer is a big ticket item, and we are on standby to help you maintain your investment. Contact us to learn more about our comprehensive service packages and preventative maintenance agreements.

For more information on homogenizer applications, cell lysis, and how to choose the right method, download our FREE eBook:

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Ultrasonic Homogenizers vs. High Pressure Homogenizers

Posted by David Shechter on Oct 13, 2016 12:30:00 PM

high pressure homogenizersUltrasonic homogenizers, or sonicators, are used in cell lysis and particle size reduction applications. This equipment uses pulsed, high frequency sound waves to disrupt particles through a phenomenon called cavitation. Cavitation occurs when a rapid pressure change causes “liquid-free zones” or cavities in a liquid. As these cavities collapse, shock waves are generated throughout the liquid, which causes the cells or large particles to rupture.

Uses and Shortcomings of Ultrasonic Homogenizers

Ultrasonic homogenizers are commonly used for processing small samples that are in suspension and don’t require any pre-grinding or cutting. They can be used for cell lysis, emulsion preparation, for mixing and dissolving purposes, and to accelerate chemical reactions.

Limitations of ultrasonic homogenizers include the generation of heat, which may be detrimental to temperature-sensitive samples. Sonicators can also shear DNA, which may or may not be desirable, depending on your application.

Ultrasonic homogenizers make a very loud, “hissing” noise and the appropriate personal protective equipment must be worn by operators and lab technicians.

Ultrasonic homogenizers do not lyse all cells equally. The cell walls of plant cells are far more resistant to sonication than cell membranes. Lastly, there is a possibility of cross contamination, as the sonicator probe comes into direct contact with the samples.

DeBEE High Pressure Homogenizers: Ideal Fluid Processing for Small and Large Volumes

Our High Pressure Homogenizers are the most efficient fluid processing equipment for particle size reduction and cell lysis. BEE International’s proprietary homogenizing cell technology drives the fluid at ultra high pressure through a small nozzle, causing cavitation. The product becomes a high velocity jet stream and flows through an absorption cell. This absorption cell contains alternating small and large orifices that create turbulence and cause fluid-on-fluid impact and shear. Process intensity is adjustable from 2,000 - 45,000 psi / 150 - 3100 bar.

DeBEE high pressure homogenizers make use of cavitation, but they also use the forces of shear and impact. Particle disruption is gentle but effective, allowing for better results in fewer passes. Best of all, our results are consistently scalable up to manufacturing volumes.

Download our free eBook “7 Key Factors to Consider When Choosing a Cell Lysis Method” to learn more about selecting the right particle size reduction or cell lysis equipment for your application:

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Topics: High Pressure, Homogenizer

Comparing the 3 Most Common Homogenizers: Ultrasonic, Bead Mill and High Pressure

Posted by Tal Shechter on Oct 12, 2016 12:30:00 PM

Ultrasonic_Bead_Mill_and_High_Pressure_aUltrasonic_Bead_Mill_and_High_Pressure_aultrasonic-bead-mill-high-pressure.jpgBEE International knows that choosing the right homogenizer can be a tricky business. You need to find the right size, right mechanism, right force and more for your specific application. Because of our extensive experience in the industry, we are here to help you make this tough decision.

Below, we have compared the characteristics of three of the most common types of homogenizers – Ultrasonic, Bead Mill, and High Pressure Homogenizers.





Type of Homogenizer


Bead Mill

High Pressure


of action

Pulsed, high frequency sound waves are used for particle size reduction and cell lysis. Ultrasonic energy is transmitted directly from the probe into the sample, or indirectly through a water bath.

The sample is fed into a chamber surrounded by beads in a closed system. The beads are rapidly agitated to grind and homogenize the sample, breaking up tissue and disrupting cells.

Liquid is driven at ultra high pressure through a small nozzle. The liquid becomes a high velocity jet stream and flows through an absorption cell, which contains alternating small and large orifices.


Cavitation, Shear


Cavitation, Turbulence, Fluid-on-Fluid Impact, Shear

Sample Type


Liquid or Solid



Great for small, liquid samples that require thorough homogenization.

Good for breaking up tissue. Quick and high-throughput. Samples are self-contained, therefore reduced opportunity for cross contamination.

Constant, uninterrupted processing pressure eliminates the possibility of contamination. Capable of producing very small, sub-micron particle sizes.

Consistent, great results in fewer passes.


Unsuitable for applications where the sample is mostly solid and / or not immersed in a liquid buffer.

Ultrasonic homogenizers can shear DNA, which could be undesirable. Generate heat and noise. Possibility of cross contamination.

Sample size limitations. Due to the nature of the mechanism of action, it is impractical to design bead mill homogenizers for large volumes.

High-pressure homogenizers tend to be large and extremely heavy. Expensive.  



Processing liquid samples in laboratories.

Processing solid tissue samples in laboratories.

Processing milk, beverages, drugs, cosmetics and more in laboratories, pilot plants and large-scale production.


BEE International high pressure homogenizing systems produce consistent and 100% scalable results. You can be sure that these results are reproducible through pilot and clinical trial settings, and up to manufacturing. We are committed to the success of your product, and will be the first to tell you if our technology or equipment is not the right fit.

Visit our website or contact us to learn more about our products and technology. For more information on homogenizers and factors to consider when choosing a cell lysis method, download our FREE eBook:

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Emulsion Products That Can Benefit from High Pressure Homogenization

Posted by Deb Shechter on Oct 11, 2016 12:30:00 PM

Emulsions are a common application in the cosmetic and pharmaceutical industries to make creams, lotions, hair conditioners, make up and many other products. For more information on emulsions in the food industry, read an earlier blog here.

An emulsion is a mixture of two immiscible liquids like oil and water. Tiny droplets of the first liquid are dispersed throughout the second liquid. With an oil in water emulsion, the oil droplets are dispersed in the water phase and the product will have a lighter feel e.g. in moisturizing lotions or day creams.


In the case of a water in oil emulsion, the water droplets are dispersed in an oil phase and the product will have a heavier, greasier feel e.g. in night creams or sunscreens. Water and silicone emulsions are another common emulsion type in cosmetic products.  

Emulsion products are also frequently used in the pharmaceutical industry. They are used to make medicines more palatable, for injectables, and for improving the visual and textural properties of medicated creams and ointments.

High Pressure Homogenization for Improved Emulsions

DeBEE high pressure homogenizers produce a homogenous mix of smaller, more uniform particles. Our innovative technology offers unique benefits for producing nano / micro emulsions. Our homogenizers can achieve stable emulsions with droplet sizes below 100nm. Particle size is so small and uniform that emulsions can become clear. Product shelf life is extended, and efficacy is increased.

Our equipment produces unprecedented results for your emulsion products by allowing you to optimize the mixing process to better achieve your desired product characteristics. This is accomplished by varying the cavitation, shear and impact forces applied to a formulation. Our high pressure homogenizers boast a sanitary design and features like validation procedures and documentation, data gathering, SCADA and automated CIP.

DeBEE High Pressure Homogenizers for Every Stage of Product Development

Our laboratory homogenizers are compact, easy to use units with small minimum sample sizes and many experimentation options with scalable results. Our pilot plant equipment gives reliable results and guaranteed scale-up, and our industrial homogenizers yield consistent results in fewer passes.

Contact us today for more information and to hear about our free sample testing program.

Are you in the Pharmaceutical Industry? For more tips on improving your emulsion products, download our FREE eBook, "Advantages of BEE Homogenizers for the Pharmaceutical Industry":

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Topics: High Pressure, Homogenization, Emulsions

3 Common Mistakes When Shopping for a Homogenizer

Posted by Deb Shechter on Oct 10, 2016 12:30:00 PM

mistakes-when-shopping-for-homogenizer.jpgWhen it comes to making a big purchase, people always want to get the best possible product for the lowest possible price. The internet has made it easy to do research, and these days most of us weigh up the pros and cons, read reviews, and compare product specifications before taking the plunge. The following article may help if you are in the market for a homogenizer. Common mistakes include:

1. Not Defining YOUR Needs

Different manufacturers and products have different requirements. Before you buy, it’s well worth your while to put pen to paper and clearly outline exactly what you need in a homogenizer. Think about:

  • Will it be running around the clock, or only a few times a month?
  • What kind of volumes will you be processing?
  • What are the regulatory requirements associated with manufacturing your product?
  • Do you have any other specific needs e.g. pasteurization, SCADA or CIP

2. Not Testing Before Purchase

Processing your product on the homogenizer is the best way of determining whether or not it will be a good fit. Although not always possible, processing it yourself in your own facility is first prize. This way, you can determine ease of use and cleaning, safety features, noise levels, compatibility with your other equipment, how many operators are needed, and more.

3. Not Thinking Ahead

A large and expensive piece of equipment is seldom a once-off purchase. Things go wrong, things get old and they break. For this reason, you should always choose your homogenizer vendor with great care. Think about:

  • Do they have a reliable reputation?
  • Is there good after-sales support available?
  • Are they local or international? If the latter, could language and distance be a barrier?
  • Do they provide training and technical support?
  • Do they provide maintenance, and what about the availability of spare parts?

BEE International: Your Leading Supplier of High Pressure Homogenizers

BEE International is a respected company with representation worldwide. We have been in operation for over two decades and have homogenizers in commercial and academic laboratories across the globe.

We provide free installations of our DeBEE high pressure homogenizers, and we pride ourselves in offering lifetime product training. Contact us for professional servicing by trained technicians and inquire about our annual Preventive Maintenance Agreements.

We offer free, confidential sample testing at our Massachusetts facility. Send us a sample of your product and we will process it on a DeBEE2000 High Pressure Homogenizer. Your processed sample, along with a detailed analysis and report, will be returned so that you can see the results for yourself.

BEE International is experienced with every aspect of homogenization, and we are waiting to help you make your decision. For more information on homogenizer applications and how to achieve efficient and consistent results, download our FREE eBook:

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Topics: Homogenizer

What is HPP?

Posted by David Shechter on Oct 7, 2016 12:30:00 PM

high pressure processingHigh Pressure Processing (HPP) is a pasteurization method that uses high pressure instead of heat to kill microorganisms in foods. This process goes by many other names too, including High Pressure Pasteurization, Pascalization, Bridgmanization, Cold Pasteurization, Ultra High Pressure (UHP) Processing, and High Hydrostatic Pressure (HHP) Processing.

HPP is used for preserving and sterilizing food products. The high pressure inactivates bacteria, viruses, yeasts, molds, and parasites present in food; as well as food enzymes. Typical pressures applied to foods range from 300 – 800 MPa (43,500 – 116,000 psi). Food products can be HPP processed with or without packaging.

Heat may be applied; however, HPP is mainly conducted at refrigerated temperatures, relying on pressure alone to process the food. The absence of heat is key; as this means that the food retains important components like vitamins, antioxidants, and its color and flavor profile. 

Applications of HPP

Products that frequently utilize HPP technology include:

  • Juices and smoothies
  • Meat products like cold cuts, ground beef and poultry, and precooked meats
  • Seafood like lobster or oysters can be shucked with HPP
  • Fresh-cut fruit and packaged fruit products like applesauce
  • Fresh-cut vegetables and packaged vegetable products like guacamole or avocado halves
  • Fruit jellies and jams
  • Dairy products like yoghurt & yoghurt-based dressings, cream products, cream cheese and milk
  • Ready-to-eat foods like packaged meals, salads, soups, and hummus
  • “Raw” style pet food

Disadvantages of HPP

HPP is not the ideal preservation method for all kinds of food, neither is it effective against all microbial forms. Spore-forming organisms are highly resistant to HPP when they are in their spore form. The spores of Clostridium botulinum, for example, can thrive in low-acid foods and produce a deadly toxin. These spores require a combination of pressure and heat, or some other antibacterial intervention in order to eliminate them.

HPP can cause undesirable sensory changes in certain foodstuffs. In foods like eggs, the denaturation of protein can be visually apparent. Very high pressures can also damage the appearance of delicate foods like strawberries or leafy greens.

DeBEE High Pressure Homogenizers: Working Hand in Hand with HPP

BEE International technology has a modular approach which supports a wide variety of process configurations including applications like HPP. Our high pressure homogenizers meet stringent FDA requirements with options such as automated control, in-line process design, data gathering, SCADA and validation documentation.

We are here to help you find the right equipment for your specific application. Contact us today to learn more about high pressure homogenization and let us help you make the right decision. 

For more information on high pressure homogenizer applications and factors to consider when choosing a cell lysis method, download our FREE eBook: 

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Topics: High Pressure Pasteurization

What Is Particle Size Reduction & How Does It Play a Part in Everyday Life?

Posted by Deb Shechter on Oct 3, 2016 12:30:00 PM

particle size reduction refers to the process of adding energy to a material in order to reduce the average particle size. We know that manufacturing industries utilize particle size reduction, but did you know that it happens every day in your own life too?

Let’s begin with your morning coffee. Before you can enjoy a delicious cup of java, you need to grind the coffee beans first. In a coffee grinder, the beans are ground down into much smaller particles, thereby increasing the surface area. We do this so that the water which percolates through the coffee can extract all those delicious, aromatic compounds (as well as the much needed caffeine!)

Next, you get into your car and drive to work. Your car is made predominantly from steel, which is made from iron ore mined from the ground. One of the first steps in this process, after removing the rocks from the earth, is comminution (size reduction) so that the valuable materials can be separated out.

Large Pieces + Energy = Smaller Pieces  

At lunchtime, you go down to the cafeteria and order a salad. Luckily for you, the chef knows a thing or two about particle size reduction. If not, you would have received an entire head of lettuce on your plate, along with a whole tomato and cucumber!

When you’re done, you toss your used napkin into the trash. Waste management companies make use of particle size reduction equipment like shredders and compactors to break down or crush waste into smaller pieces.

Later when you head home, you make yourself a sandwich. Your bread was baked with flour, which was made (or milled) by crushing the grain into smaller pieces. Lastly, just before bed, you wash your face and apply your face cream, which has probably been manufactured using a homogenizer.

Homogenization, you guessed it, is a kind of particle size reduction. It uses mechanical force to break down particles or droplets in a liquid into smaller and more uniform sizes. Once the face cream has been homogenized, it is less likely to separate out, thereby improving the aesthetic and prolonging the shelf life.

Interested in learning more about particle size reduction and how to make the process more efficient? Contact us, and download our free eBook: “How to Achieve Efficient & Consistent Particle Size Reduction.”

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Topics: Particle Size Reduction

BEE International: Your Lifelong Partner for Homogenizing Applications

Posted by David Shechter on Sep 30, 2016 12:30:00 PM

partner-for-homogenizing-applications.jpgDeBEE high pressure homogenizers are used worldwide in numerous different manufacturing industries. They bring unique benefits to many applications including particle size reduction, micro/nano emulsions, dispersions and cell lysis.

BEE International knows that every product is unique, and requires specific modifications and procedures. We are also keenly aware of the stringent regulatory requirements placed on manufacturers in the food, pharmaceutical, chemical and biotechnology industries; and we have designed our homogenizers in compliance with these regulations.

We are committed to lifetime customer support, which begins even before you purchase a DeBEE High Pressure Homogenizer. We offer:

  • Ongoing Education and Product Training

BEE International applications and service group provides on-site homogenizer installation, training, and commissioning for new and existing DeBEE systems. We offer pre-installation operator training, and training for any new employees further down the line.

We will also gladly provide information on the benefits of our specific technology to non-operator staff like marketing and management.

  • Application Development Support

Whether you are developing a new product or improving an existing one, let us help. We offer free, confidential sample testing at our Massachusetts facility. Send us your product, and we will process it on a DeBEE2000 High Pressure Homogenizer, and send it back along with a detailed evaluation and analysis report.

  • Technical Support

BEE International offers comprehensive technical support via telephone or email. Our helpful technical support staff are quick to respond and will help in resolving your query in record time.

  • Try before you buy

Before committing to the purchase of a high pressure homogenizer, you have the unique option of trying it out first. We will test your product on our machine in your own laboratory, or alternatively you can send us a sample for a full analysis.

BEE International high pressure homogenizing systems produce consistent and 100% scalable results. You can be sure that these results are reproducible through pilot and clinical trial settings, and up to manufacturing. We are committed to the success of your product, and will be the first to tell you if our technology or equipment is not the right fit.

We invite you to partner with us from the very beginning. Your products deserve to be produced on top-tier process equipment systems. Contact us to learn more about our high pressure homogenization products and technology.

For more information on homogenizer applications and how to choose the right cell lysis method, download our FREE eBook:

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Topics: Homogenizer

5 Ways to Test Your Products After Homogenization

Posted by Deb Shechter on Sep 29, 2016 12:30:00 PM

test-your-products-after-homogenization.jpgHomogenizers are used to produce a countless number of products across many industries. In determining the ideal homogenizer operating pressure and settings for a particular product, the first step is to establish an effective method of evaluation. Here we discuss five ways to test that your homogenizer is operating correctly:

  • The Babcock Fat test

Dating back from the early part of the 20th century, this test is a useful way to determine the fat content of a homogenized milk sample. Basically, milk is measured into a graduated test tube, and an equal volume of sulfuric acid is added. This mixture is centrifuged, and the fat that separates out is measured.

  • The Top and Bottom test

Also common in milk testing, this test determines the “homogenization index”. The top layer of milk is separated from a sample that has been sitting for 48 hours at a temperature between 40 and 50 °F (4 to 8 °C). The percentage of fat in the remaining (bottom) portion of the milk sample is subtracted from the percentage of fat in the top portion. This difference is divided by the percentage of fat in the top portion, and these are all multiplied by 100. The index should be less than 10 percent.

  • Microscope

A microscope can be used to determine the average particle or droplet size of the homogenized product. This method is useful to provide a quick indication as to the product homogeneity; but it lacks objectivity.

The Farrall Index is a microscopic method for determining homogenization efficiency, based on the number of droplets having a diameter of < 2 µ. A Farrall index ranging from 5 to 7 implies “excellent” homogenization efficiency.

  • Rapid Optical test

Homogenizer efficiency can be tested directly by measuring the transmission of milk samples of thickness ca. 0·1 mm., using wavelengths in the near infrared region.

  • Viscosity test

When the dispersed and continuous-phase viscosities are low, it means that your homogenizer is operating efficiently.

Improve Your Products with DeBEE High Pressure Homogenizers

Did you know that BEE International offers free, confidential sample testing and evaluation? Simply contact us to request an application questionnaire, and send the completed form back to us, along with a sample of your product. Your product will be processed on a DeBEE 2000 High Pressure Homogenizer and returned to you, along with a detailed evaluation and analysis report.

For more information on particle size reduction and how you can achieve efficient and consistent results, download our FREE eBook:

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Topics: Homogenization

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