Fiber optic UV spectrometers are commonly used in dissolution testing for several reasons:
1. High sensitivity: Fiber optic UV spectrometers are highly sensitive and can accurately measure low concentrations of dissolved compounds. This is crucial in dissolution testing, where the goal is to detect and quantify the amount of substance that dissolves from a solid dosage form into a liquid medium.
2. Real-time monitoring: Fiber optic UV spectrometers provide real-time monitoring of the dissolution process. They can continuously measure the concentration of the dissolved compound during the experiment, allowing for precise determination of the dissolution rate and overall dissolution profile.
3. Minimal sample handling: Fiber optic probes from the spectrometer can be directly immersed into the dissolution medium, eliminating the need for sample handling and thus reducing the risk of errors or contamination. This ensures accurate and reliable measurements throughout the entire dissolution process while reducing sample handling and measurement time and reducing wear and tear on sampling instrumentation.
4. Versatility: Fiber optic UV spectrometers can be easily integrated into different dissolution apparatuses, such as USP dissolution testers, making them suitable for a wide range of dissolution testing methods and configurations.
5. Compact size: Fiber optic UV spectrometers are compact and can be easily installed in limited laboratory space. They also require minimal maintenance, making them cost-effective and convenient for routine dissolution testing.
Overall, the use of fiber optic UV spectrometers in dissolution testing offers improved sensitivity, real-time monitoring, ease-of-use, and compatibility with different dissolution methods, making them a preferred choice for many pharmaceutical laboratories.
Pion’s Rainbow fiber optic UV-vis dissolution monitoring system allows up to 8 independent channels, or fiber optic probes, to be used simultaneously for real-time monitoring of dissolution in a variety of dissolution baths. Rainbow can also be used to measure passive transport across membranes (flux) in vitro to help predict in vivo molecular behavior across membranes. Contact us today to learn more.
SEE ALSO:
Short Introduction to Rainbow in situ UV Dissolution Tester on Youtube. (1 min 38 sec)
