Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration

Purpose.  Investigation of the transdermal drug delivery route has intensified recently for both novel and existing drug products. The aim of this work was to adapt the parallel artificial membrane permeability assay (PAMPA) for predicting skin penetration by employing an artificial membrane mimicking the stratum corneum layer of human skin.

Conclusions.  The Skin-PAMPA model predicts human skin permeability reasonably well, and because of its standardization potential and high-throughput nature it can be a valuable cost effective alternative to Franz cell studies for early skin penetration prediction.