Considerations on the Controlled Release of Injectable Insulin Using Scissor

It is known that our newly developed β-cyclodextrincyclodextrin-grafted chitosan (BCC), binds strongly with peptides. In addition, morphology of the complex changes depending on the buffer type. When mixed with insulin in an acetate buffer, BCC is conjugated in a molecular dissolved state. However, when it is mixed with insulin in a citrate buffer solution, the chitosan main chain is ionically crosslinked via citric acid, which forms nanoparticulate complexes. In this application note an assessment was performed using Scissor with the aim of controlling the absorption profile of the subcutaneous formulation using the same formulation.