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Measurement of Extreme pKas

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Measurement of Extreme pKas

Applications Note

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Measurement of Extreme pKas with the Pion T3

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Dissolve Macro Orange

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Measurement of Extreme pKas

Applications Note

This application note describes some experimental designs for the PionT3 which may be used to overcome these problems, giving reliable pKa values between 0.7 and >13.

Applications Note

Dissolve Macro Orange
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Micro DeBEE
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Effects of drug-rich phase properties formed by liquid-liquid phase separation on the drug membrane permeability analyzed using μFLUX
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Introduction to Pion's BEE brand high-pressure homogenizers
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Development and characterization of an in vitro method for investigating pharmacokinetic behavior of long-acting subcutaneously injected therapeutics
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Introduction to log P and log D measurement using PionT3
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Measuring log P of samples that are hard to dissolve in water and octanol
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The use of cosolvent pKa assays for poorly soluble compounds
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Measurement of Extreme pKas
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Solubility and Supersaturation - A Brief Introduction
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Scissor N3 overview and demo
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Human Collagen’s Role within Artificial Extracellular Matrices used for in vivo Analysis of Injectable Formulations
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Scissor as a platform for the analysis of non-protein subcutaneous formulations
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Understanding excipient effect in vitro using the Pion Scissor
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Considerations on the Controlled Release of Injectable Insulin Using Scissor
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Scissor App Note_ECM-XR validation, peptides, mAbs, small molecules
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Reversal of IDO-mediated cancer immune suppression
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Control of Oral Bioavailability by Particle Sizes
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Method for preparing propofol emulsion for vascular injection
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Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
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Nanoparticle Formation
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Barriers and solutions for mimicking an in vivo extracellular environment with in vitro tools
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Creating consistency & predictability in cannabis-infused beverages - Vertosa and Pion Inc.
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Surface dissolution imaging to investigate the influence of common ion effect on Papaverine hydrochloride
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MiniDeBEE
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Nano DeBEE
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DeBEE 2000
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Dissolution Testing
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PrepEngine Demo: Chinese Traditional Medicine Sample Prep | Goji Berries & Baikal Skullcap Root
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Interplay between Ketoconazole Cocrystal Supersaturation and Trans-membrane Flux Behavior In Simulated Intestinal Fluids
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Application of In Situ Potentiometric Sensors to Study Dissolution-Precipitation Behavior of Electrospray-Generated Loperamide Nanoparticles
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Cyclodextrin-Based Orally Fast Dissolving Drug Delivery System of Aripiprazole and Its In Vitro Dissolution-Permeation Testing Using µFLUX
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Real Time Dissolution Monitoring of Dual Component Drug Product Using Fiber Optic System
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MacroFLUX An Integration of Absorption Chamber with USP II Dissolution Apparatus
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Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Surfactant Containing
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Determination of the Intrinsic Dissolution Rate (IDR) from a Powder and using a Miniaturized Wood’s Apparatus
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Penetration Enhancer Effect of Sucrose Esters
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Prediction of Caco-2 pH-Dependent Permeability based on High Quality in vitro Training Set
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Comparison of Miniaturized Intrinsic Dissolution Rate Measurement to Traditional Wood’s Apparatus
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Novel in vitro PK (non-animal PK) Assay for Excipient/Vehicle Formulation Studies
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Drug Permeation in Skin PAMPA and Franz Cell Model
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In Situ Solubility and Dissolution of Concentrated Solutions
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Prediction of in situ Blood-Brain Barrier Permeability using BBB PAMPA Model
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Impact of Biorelevant Media on Apparent Solubility and Biopharmaceutical Classification of Poorly Soluble Compounds
Poster
Very Thin PAMPA Membranes Indicate Higher Antipyrene Permeability but are Fragile and Contain Leaky Water Pores
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Nanoparticle Formulation of Gresiofulvin
Poster
Universal Potentiometric Sensors Protein Binding
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In Vitro-In Vivo Correlation (IVIVC): Prediction of pK a at 37°C, From the Measured Value at 25°C
Poster
Human Jejunal Permeability Predicted from Caco-2 Assay - A Biophysical Model Applied to Fluoroquinolone Antimicrobials
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Novel Device and Method for in situ UV Dissolution and Precipitation Monitoring in 96-well Plate
Poster
Evaluation of Optimized Caco-2 Permeability Measurements
Poster
Developing Skin PAMPA for Transdermal Patches
Poster
Supersaturation and Transmembrane Flux of Meloxicam
Poster
Universal Potentiometric Sensors Food Matrixes
Poster
Preparation, Physical Characterization and Solubility-Dissolution Testing of Loratidine Hot Melt Extrudates Prepared on a Laboratory Mixing Extruder
Poster
Evaluating Drug Salt Dissolution and Precipitation Processes for Rational Formulation Strategies
Poster
Skin-PAMPA: A New Method for Fast Prediction of Skin Penetration
Poster
Monitoring Supersaturation State of Solid Dispersions of Low Solubility Compounds
Poster
Skin-PAMPA: Fast Prediction of Skin Penetration
Poster
Comparison of Naproxen Release from Nano- and Microsuspensions with Its Dissolution from Untreated and Micronized Powder
Poster
Soluplus® Maintains the Supersaturation of Carbamazepine from Amorphous Solid Dispersions
Poster
In Situ Monitoring of Supersaturation State for Solid Dispersions of Low Soluble Compounds
Poster
Application of Skin PAMPA to Differentiate Between Topical Pharmaceutical Formulations of Ibuprofen
Poster
Dissolution and Precipitation Monitoring of Crystalline Salts
Poster
Assessment of Transdermal Penetration Enhancement by Topical Pharmaceutical Excipients Using Skin PAMPA Method
Poster
Universal Potentiometric Sensors: Application for Real Time Concentration Monitoring in Complex Biorelevant Media
Poster
Real Time Monitoring of Dissolution, Supersaturation and Precipitation Processes in Dynamically Changing Biorelevant Media
Poster
Dissolution-Permeability Apparatus with Integrated In Situ Concentration Monitoring of both Donor and Receiver Compartments
Poster
Novel HT Method for Parallel Excipient/Vehicle Formulation Studies
Poster
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Poster
In Situ Method for Monitoring Free Drug Concentration Released from Nanoparticles
Poster
Degree and Extent of Supersaturation of Amorphous Pharmaceuticals and Their Flux through Lipophilic Membranes
Poster
Progress in pKa Determination Technology: Case Studies in Low and High Soluble Flavonoids
Poster
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Poster
Application of simultaneous dissolution-absorption apparatus for screening formulations before bioequivalence studies
Poster
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Poster
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools
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Differentiating itraconazole formulations based on the flux through artificial lipophilic membranes
Poster
Utilization of pH-Metric Titration
Poster
Application of Skin Pampa to Cosmetic Solvent Screening
Poster
Karl Box Sunrise Presentation
Poster
Application of MacroFLUX™ Apparatus for Screening Formulations before Bioequivalent Studies
Poster
Supersaturation in additives and GI fluids
Poster
Determination of Polymer Effectiveness
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